Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Pengyi Yan"'
Autor:
Fang Zhang, Pengyi Yan, Huijing Yu, Huangying Le, Zixuan Li, Jiahuan Chen, Xiaodong Liang, Shiyan Wang, Weiting Wei, Li Liu, Yan Zhang, Xing Ji, Anyong Xie, Wantao Chen, Zeguang Han, William T. Pu, Sun Chen, Yingwei Chen, Kun Sun, Baoxie Ge, Bing Zhang
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107974- (2020)
Summary: Attenuated DNA repair leads to genomic instability and tumorigenesis. BRCA1/BARD1 are the best-known tumor suppressors that promote homology recombination (HR) and arrest cell cycle. However, it remains ambiguous whether and how their E3 lig
Externí odkaz:
https://doaj.org/article/abe438e6f2284744a70a670ae7b7c734
Autor:
Junling Liu, Pengyi Yan, Yan Zhang, Fengyuan Chen, Gengze Wu, Tao Zhuang, Weiting Wei, Junhao Xiong, Chunyu Zeng, Zhijie Liu, Zixuan Li, Zilong Geng, Xiao Yu Tian, Yuzhen Zhang, Bing Zhang, Yu Huang, Kun Sun
Publikováno v:
Cell reports. 37(8)
Cellular senescence is associated with pleiotropic essential physiopathological processes including aging and age-related diseases. The persistent DNA damage response (DDR) is a major stress leading to senescence, but the underlying molecular link re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f43a757841d0f6c5e09891ac09692c
https://pubmed.ncbi.nlm.nih.gov/34818543
https://pubmed.ncbi.nlm.nih.gov/34818543
Autor:
Yanan Lu, Fang Zhang, Yuejuan Xu, Zilong Geng, Jian-an Wang, Junling Liu, Tao Zhuang, Chen Chen, Zixuan Li, Dao Wen Wang, Yingmei Lou, Wei Zhu, Pengyi Yan, Yan Zhang, Gengze Wu, Bing Zhang, Chunyu Zeng, Yuzhen Zhang, Xinyang Hu, Kun Sun, Huijing Yu, William T. Pu, Shasha Zhang
Publikováno v:
Circulation. 143(20)
Background: Heart failure (HF) is among the leading causes of morbidity and mortality, and its prevalence continues to rise. LARP7 (La ribonucleoprotein domain family member 7) is a master regulator that governs the DNA damage response and RNAPII (RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc45c907368822a3c6a195611c6fae7
https://pubmed.ncbi.nlm.nih.gov/33663221
https://pubmed.ncbi.nlm.nih.gov/33663221
Autor:
Xusheng Luo, Ze-Guang Han, Shiyan Wang, Jiahuan Chen, Jingfang Wang, Kun Sun, Zixuan Li, Xiaodong Liang, Sean M. Stevens, William T. Pu, Huijing Yu, Guo-Cheng Yuan, Weiting Wei, Huangying Le, Peter J. Park, Daniel S. Day, Zhijie Liu, Fang Zhang, Sara P. Garcia, Pengyi Yan, Yan Zhang, Bing Zhang
Publikováno v:
Genome Research. 29:193-207
Cell behaviors are dictated by epigenetic and transcriptional programs. Little is known about how extracellular stimuli modulate these programs to reshape gene expression and control cell behavioral responses. Here, we interrogated the epigenetic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba69c8d5b30fa5454436b60940108067
https://doi.org/10.1101/gr.239053.118
https://doi.org/10.1101/gr.239053.118
Autor:
Carissa Chen, Scott Lee, Katherine G. Zyner, Milan Fernando, Victoria Nemeruck, Emilie Wong, Lee L. Marshall, Jesse R. Wark, Nader Aryamanesh, Patrick P.L. Tam, Mark E. Graham, Anai Gonzalez-Cordero, Pengyi Yang
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114219- (2024)
Summary: Defining the molecular networks orchestrating human brain formation is crucial for understanding neurodevelopment and neurological disorders. Challenges in acquiring early brain tissue have incentivized the use of three-dimensional human plu
Externí odkaz:
https://doaj.org/article/8a7fd637d50344138b8dbe6664cdb3e7
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background The identification of genes that vary across spatial domains in tissues and cells is an essential step for spatial transcriptomics data analysis. Given the critical role it serves for downstream data interpretations, various metho
Externí odkaz:
https://doaj.org/article/e391a56a091c409abdd3094735b70892
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Feature selection is an essential task in single-cell RNA-seq (scRNA-seq) data analysis and can be critical for gene dimension reduction and downstream analyses, such as gene marker identification and cell type classification. Mos
Externí odkaz:
https://doaj.org/article/c31c3be8d8db4c28a21d2de841f25325
Autor:
Shiyan Wang, Fang Zhang, Huangying Le, Sara P. Garcia, Kun Sun, Xiaodong Liang, Zixuan Li, Weiting Wei, Huijing Yu, William T. Pu, Shasha Zhang, Guo-Cheng Yuan, Jiahuan Chen, Li Liu, Bing Zhang, Pengyi Yan, Yan Zhang, Yingwei Chen, Sun Chen
Publikováno v:
Cell Death and Disease, Vol 11, Iss 1, Pp 1-15 (2020)
Cell Death & Disease
Cell Death & Disease
The bivalent domain (BD) at promoter region is an unique epigenetic feature poised for activation or repression during cell differentiation in embryonic stem cell. However, the function of BDs in already differentiated cells remains exclusive. By pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c75e34c5cbbb359ad5ea3d79a021c3
https://doi.org/10.1038/s41419-020-2228-3
https://doi.org/10.1038/s41419-020-2228-3
Autor:
Baoxie Ge, Weiting Wei, Shiyan Wang, Sun Chen, Yingwei Chen, Jiahuan Chen, Li Liu, Wantao Chen, Xiaodong Liang, Bing Zhang, Xing Ji, Fang Zhang, Zixuan Li, Huangying Le, William T. Pu, Anyong Xie, Huijing Yu, Pengyi Yan, Yan Zhang, Kun Sun, Ze-Guang Han
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107974-(2020)
Summary Attenuated DNA repair leads to genomic instability and tumorigenesis. BRCA1/BARD1 are the best-known tumor suppressors that promote homology recombination (HR) and arrest cell cycle. However, it remains ambiguous whether and how their E3 liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd9f19ee4a07ad366840fd32832b13e
https://pubmed.ncbi.nlm.nih.gov/32814055
https://pubmed.ncbi.nlm.nih.gov/32814055
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Inferring gene regulatory networks (GRNs) is a fundamental challenge in biology that aims to unravel the complex relationships between genes and their regulators. Deciphering these networks plays a critical role in understanding the underlyi
Externí odkaz:
https://doaj.org/article/c501d927ae964ad8979177ec938ad4f5