Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Pengxin, Chai"'
Autor:
Jae Yeon Hwang, Pengxin Chai, Shoaib Nawaz, Jungmin Choi, Francesc Lopez-Giraldez, Shabir Hussain, Kaya Bilguvar, Shrikant Mane, Richard P Lifton, Wasim Ahmad, Kai Zhang, Jean-Ju Chung
Publikováno v:
eLife, Vol 12 (2023)
Radial spokes (RS) are T-shaped multiprotein complexes on the axonemal microtubules. Repeated RS1, RS2, and RS3 couple the central pair to modulate ciliary and flagellar motility. Despite the cell type specificity of RS3 substructures, their molecula
Externí odkaz:
https://doaj.org/article/d9710931c5ef46c08e60e959f221e930
Autor:
Jae Yeon Hwang, Pengxin Chai, Shoaib Nawaz, Jungmin Choi, Francesc Lopez-Giraldez, Shabir Hussain, Kaya Bilguvar, Shrikant Mane, Richard P. Lifton, Wasim Ahmad, Kai Zhang, Jean-Ju Chung
Publikováno v:
bioRxiv
Radial spokes (RSs) are T-shaped multiprotein complexes in the 9+2 axoneme of motile cilia and flagella that couple the central pair to the peripheral doublet microtubules. RS1, RS2, and RS3 are repeated along the outer microtubule of the axoneme and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a6dc4ab8e09aa571ad70b833f4211e
https://doi.org/10.1101/2023.02.25.530050
https://doi.org/10.1101/2023.02.25.530050
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2623
Cryo-electron microscopy (cryo-EM) has become the mainstream technique for studying macromolecular structures. Determining the structures of protein complexes is more accessible to structural biologists than ever before. Nevertheless, obtaining high-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ad8e3b595555946d187241e50214103
https://pubmed.ncbi.nlm.nih.gov/36602691
https://pubmed.ncbi.nlm.nih.gov/36602691
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629574
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0cf8b47b6c74a803aba2fd7841d6937
https://doi.org/10.1007/978-1-0716-2958-1_16
https://doi.org/10.1007/978-1-0716-2958-1_16
Autor:
William D. Ton, Yue Wang, Pengxin Chai, Cissloyny Beauchamp-Perez, Nicholas T. Flint, Lindsay G. Lammers, Hao Xiong, Kai Zhang, Steven M. Markus
The lissencephaly-related protein LIS1 is a critical regulator of cytoplasmic dynein that governs motor function and intracellular localization (e.g., to microtubule plus-ends). Although LIS1 binding is required for dynein activity, its unbinding pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::726eb8c327882e3d62e15a5b56940dab
https://doi.org/10.1101/2022.11.08.515461
https://doi.org/10.1101/2022.11.08.515461
Autor:
Jonathon Howard, Pengxin Chai, Fangheng Hu, Yin-Wei Kuo, Yue Wang, Long Han, Yuchen Yang, Renbin Yang, Qinhui Rao, Kai Zhang
Publikováno v:
Nature Structural & Molecular Biology
Thousands of outer-arm dyneins (OADs) are arrayed in the axoneme to drive a rhythmic ciliary beat. Coordination among multiple OADs is essential for generating mechanical forces to bend microtubule doublets (MTDs). Using electron microscopy, we deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27357ea41ece455d7dc03ee4898c389a
https://doi.org/10.1038/s41594-021-00656-9
https://doi.org/10.1038/s41594-021-00656-9
Recently released AlphaFold 2 shows a high accuracy when predicting most of the well- structured single protein chains, and subsequent works have also shown that providing pseudo-multimer inputs to the single-chain AlphaFold 2 can predict complex int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0644fc01f0e8b6f3935542f00c019b4
https://doi.org/10.1101/2022.07.08.499384
https://doi.org/10.1101/2022.07.08.499384
Publikováno v:
Nature Structural & Molecular Biology. 30:564-564
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::642de7e2fdc203cf57e8c74c8436031c
https://doi.org/10.1038/s41594-023-00961-5
https://doi.org/10.1038/s41594-023-00961-5
Accurately regulated ciliary beating in time and space is critical for diverse cellular activities, which impact the survival and development of nearly all eukaryotic species. An essential beating regulator is the conserved central apparatus (CA) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b145dc4f8f0dee1f887fe5b9a6d4a5
https://doi.org/10.1101/2022.01.23.477438
https://doi.org/10.1101/2022.01.23.477438