Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Pengxiang She"'
Autor:
Pengxiang She, Kristine C Olson, Yoshihiro Kadota, Ayami Inukai, Yoshiharu Shimomura, Charles L Hoppel, Sean H Adams, Yasuko Kawamata, Hideki Matsumoto, Ryosei Sakai, Charles H Lang, Christopher J Lynch
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59443 (2013)
Branched-chain amino acids (BCAAs) are circulating nutrient signals for protein accretion, however, they increase in obesity and elevations appear to be prognostic of diabetes. To understand the mechanisms whereby obesity affects BCAAs and protein me
Externí odkaz:
https://doaj.org/article/bc7491a2b576400fbe7fe655b6dde271
Autor:
Pengxiang She
Twenty cows were assigned at parturition into two groups to study metabolic effects of continuous infusions of glucagon. Groups were normal controls and normal cows treated with glucagon at 10 mg/d for 14 d starting at 21 d postpartum. Daily blood sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cef28d0bc0d68cb68f831fe4f785d2de
https://doi.org/10.31274/rtd-180813-13313
https://doi.org/10.31274/rtd-180813-13313
Autor:
Tracy G. Anthony, Judy K. Cundiff, Piyawan Bunpo, Robert A. Harris, Ronald C. Wek, Pengxiang She
Publikováno v:
Journal of Biological Chemistry. 288:31250-31260
Branched-chain amino acid (BCAA) catabolism is regulated by branched-chain α-keto acid dehydrogenase, an enzyme complex that is inhibited when phosphorylated by its kinase (BDK). Loss of BDK function in mice and humans causes BCAA deficiency and epi
Publikováno v:
Journal of Biological Chemistry. 285:33718-33726
It remains unclear how α-ketoisocaproate (KIC) and leucine are metabolized to stimulate insulin secretion. Mitochondrial BCATm (branched-chain aminotransferase) catalyzes reversible transamination of leucine and α-ketoglutarate to KIC and glutamate
Autor:
Kavitha Gowda, Pengxiang She, Zhiyou Zhang, Christopher J. Lynch, Kathleen Griffin, Yingsheng Zhou
Publikováno v:
Journal of Applied Physiology. 108:941-949
Exercise enhances branched-chain amino acid (BCAA) catabolism, and BCAA supplementation influences exercise metabolism. However, it remains controversial whether BCAA supplementation improves exercise endurance, and unknown whether the exercise endur
Autor:
Jessica G. Judson, Kevin P. Maresca, Charles H. Lang, Pengxiang She, Christopher J. Lynch, Vance L. Albaugh, John Joyal
Publikováno v:
Molecular psychiatry
Olanzapine and other atypical antipsychotics cause metabolic side effects leading to obesity and diabetes; although these continue to be an important public health concern, their underlying mechanisms remain elusive. Therefore, an animal model of the
Autor:
Ji-Youn Youn, Thomas M. Vondriska, Peipei Ping, Yibin Wang, Sarah Warburton, Pengxiang She, Christopher J. Lynch, Haipeng Sun, Hua Cai, Gang Lu
Publikováno v:
Journal of Clinical Investigation. 119:1678-1687
The branched-chain amino acids (BCAA) are essential amino acids required for protein homeostasis, energy balance, and nutrient signaling. In individuals with deficiencies in BCAA, these amino acids can be preserved through inhibition of the branched-
Autor:
Robert A. Frost, Pengxiang She, Anne M. Pruznak, Rachel Lantry, Ly Q. Hong-Brown, Charles H. Lang, Thomas C. Vary
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 295:E964-E973
The mechanism by which human immunodeficiency virus (HIV)-1 infection in humans leads to the erosion of lean body mass is poorly defined. Therefore, the purpose of the present study was to determine whether transgenic (Tg) rats that constitutively ov
Publikováno v:
Journal of Dairy Research. 75:84-89
During early lactation, many dairy cows develop fatty liver, which is associated with decreased health and reproductive performance. Currently, fatty liver can be detected reliably only by using liver biopsy followed by chemical or histological analy
Autor:
Brittany A. Lennox, Tracy G. Anthony, Emily T. Mirek, Pengxiang She, Michael E. Fusakio, Ronald C. Wek, Gabriel J. Wilson, Gregory C. Henderson, Rana J. T. Al Baghdadi, Joseph L. Dixon
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 308(4)
The antileukemic agent asparaginase triggers the amino acid response (AAR) in the liver by activating the eukaryotic initiation factor 2 (eIF2) kinase general control nonderepressible 2 (GCN2). To explore the mechanism by which AAR induction is neces