Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Pengwu Zheng"'
Autor:
Linxiao Wang, Xiaoling Huang, Shidi Xu, Yufeng An, Xinya Lv, Wufu Zhu, Shan Xu, Yuanbiao Tu, Shuhui Chen, Qiaoli Lv, Pengwu Zheng
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract Background Facing the significant challenge of overcoming drug resistance in cancer treatment, particularly resistance caused by mutations in epidermal growth factor receptor (EGFR), the aim of our study was to identify potent EGFR inhibitor
Externí odkaz:
https://doaj.org/article/dc1948ba5a58471095b3f8bb7ecc4a8e
Autor:
Xiaobo Liu, Yuzhen Li, Qian Zhang, Qingshan Pan, Pengwu Zheng, Xinyang Dai, Zhaoshi Bai, Wufu Zhu
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
In this study, we designed and synthesized a series of novel [1,2,4]triazolo [4,3-a]pyrazine derivatives, and evaluated them for their inhibitory activities toward c-Met/VEGFR-2 kinases and antiproliferative activities against tested three cell lines
Externí odkaz:
https://doaj.org/article/910ccfd3cff647398a4d6ac448940e3b
Autor:
Qian Zhang, Xiaobo Liu, Wenhui Gan, Jinjin Wu, Hualan Zhou, Zunhua Yang, Yiling Zhang, Min Liao, Ping Yuan, Shan Xu, Pengwu Zheng, Wufu Zhu
Publikováno v:
ACS Omega, Vol 5, Iss 27, Pp 16482-16490 (2020)
Externí odkaz:
https://doaj.org/article/d491cecffc82411f89ec6ad04e48b7f6
Autor:
Caolin Wang, Shan Xu, Liang Peng, Bingliang Zhang, Hong Zhang, Yingying Hu, Pengwu Zheng, Wufu Zhu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 203-217 (2019)
A series of quinazoline derivatives with benzylidene hydrazine carboxamide were designed and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti-proliferative activity against A549, HepG2, MCF-7 and H1975 cells. Furthermore, six
Externí odkaz:
https://doaj.org/article/b6667df4acdd496db8d0f8b03a20c120
Autor:
Yuanbiao Tu, Caolin Wang, Zunhua Yang, Bingbing Zhao, Luogen Lai, Qi Yang, Pengwu Zheng, Wufu Zhu
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 16, Iss , Pp 462-478 (2018)
Aimed at discovering effective EGFR inhibitors, six series of quinazoline derivatives bearing a semicarbazone moiety were designed, synthesized and evaluated in different cancer cell lines (A549, HepG2, MCF-7 and PC-3). Most of the selected compounds
Externí odkaz:
https://doaj.org/article/ee56ad5b4a9649ee836c8b9185c0f7e9
Publikováno v:
Molecules, Vol 26, Iss 10, p 3041 (2021)
Two series of olmutinib derivatives containing an acrylamide moiety were designed and synthesized, and their IC50 values against cancer cell lines (A549, H1975, NCI-H460, LO2, and MCF-7) were evaluated. Most of the compounds exhibited moderate cytoto
Externí odkaz:
https://doaj.org/article/734fc3db807747daa4f7d4c019369723
Publikováno v:
Molecules, Vol 25, Iss 11, p 2666 (2020)
Vascular endothelial growth factor receptor 2 (VEGFR-2) binds to VEGFR-A, VEGFR-C and VEGFR-D and participates in the formation of tumor blood vessels, mediates the proliferation of endothelial cells, enhances microvascular permeability, and blocks a
Externí odkaz:
https://doaj.org/article/60cade790cfc49f4ab07da85b8d6ce9b
Publikováno v:
Materials Research Express, Vol 7, Iss 1, p 015049 (2020)
The hollow glass microspheres (HGMs) with low density were used as the support to obtain the floating visible-light photocatalysts (HGMs–Ag _3 PO _4 ) composites, in which silver orthophosphate (Ag _3 PO _4 ) was dispersed on the surface of HGMs vi
Externí odkaz:
https://doaj.org/article/e8315044683d431bbd5bb8fcd6eece2f
Publikováno v:
Molecules, Vol 20, Iss 10, Pp 19361-19371 (2015)
Two series of novel sorafenib analogs containing a sulfonylurea unit were synthesized and their chemical structures were confirmed by 1H-NMR, 13C-NMR, MS spectrum and elemental analysis. The synthesized compounds were evaluated for the cytotoxicity a
Externí odkaz:
https://doaj.org/article/c025b95534f24f28b1a775102b81b640
Autor:
Lide Yu, Qinqin Wang, Caolin Wang, Binliang Zhang, Zunhua Yang, Yuanying Fang, Wufu Zhu, Pengwu Zheng
Publikováno v:
Molecules, Vol 24, Iss 19, p 3422 (2019)
Three series of novel thienopyrimidine derivatives 9a−l, 15a−l, and 18a−h were designed and synthesized, and their IC50 values against four cancer cell lines HepG-2, A549, PC-3, and MCF-7 were evaluated. Most compounds show moderate cytotoxicit
Externí odkaz:
https://doaj.org/article/cd9a5b279d8547d7ba87fbbd38d36a8e