Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Pengfei She"'
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
With the growing antibiotic resistance in Staphylococcus aureus, it is imperative to develop innovative therapeutic strategies against new targets to reduce selective survival pressures and incidence of resistance. In S. aureus, interbacterial commun
Externí odkaz:
https://doaj.org/article/5312bd36721c4a60ad732a03c12b30d8
Autor:
Yuan Wu, Pingyun Wu, Ruolan Wu, Huilong Li, Yao Duan, Chaoni Cai, Zixin Liu, Pengfei She, Di Zhang
Publikováno v:
AMB Express, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) infection poses a severe threat to global public health due to its high mortality. Currently, polymyxins are mainly used for the treatment of Gram-negative bacterial-related infection, while
Externí odkaz:
https://doaj.org/article/084e7f24b017455b9efcf31ddc022643
Publikováno v:
AIDS Research and Therapy, Vol 20, Iss 1, Pp 1-9 (2023)
Abstract Human immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long
Externí odkaz:
https://doaj.org/article/67c58ee221474c55b215322c164c775d
Publikováno v:
mSystems, Vol 8, Iss 6 (2023)
ABSTRACT Staphylococcus aureus is an important human pathogen that often leads to hospital-acquired and community-acquired infections. The appearance of methicillin-resistant S. aureus (MRSA) has made the treatment extremely challenging. There is an
Externí odkaz:
https://doaj.org/article/e484d6a8406940b9b72ee3e4a9ca5a8e
Publikováno v:
AMB Express, Vol 12, Iss 1, Pp 1-17 (2022)
Key points Benzoxaborole Compound Tavaborole was discovered against E. coli by using HTS. Tavaborole showed synergistic efficacy with aminoglycosides in vitro and in vivo. The main mechanism of synergy was promoting protein mistranslation mutually.
Externí odkaz:
https://doaj.org/article/913208a92e9d4082bc231ebd095ffbef
Publikováno v:
AMB Express, Vol 12, Iss 1, Pp 1-15 (2022)
Key points Ceritinib showed fierce lethality to the planktonic and persistent S. aureus. Ceritinib were highly effective in MRSA biofilm eradication and inhibition. The bactericidal mechanisms of ceritinib were showed by membrane breaking and ROS act
Externí odkaz:
https://doaj.org/article/aa2ac703962c4307b8c03d2b52a3809c
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT The increasing occurrence of extensively drug-resistant and pan-drug-resistant K. pneumoniae has posed a serious threat to global public health. Therefore, new antimicrobial strategies are urgently needed to combat these resistant K. pneumon
Externí odkaz:
https://doaj.org/article/64060f7457b34950a7d93b43cac10993
Publikováno v:
International Journal of Medical Microbiology, Vol 313, Iss 2, Pp 151578- (2023)
There has been an explosion in the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) because of the indiscriminate use of antibiotics. In this study, we repurposed hexestrol (HXS) as an antibacterial agent to fight planktonic and biofi
Externí odkaz:
https://doaj.org/article/923c62ab632042ef9f42fdcd3fbb6acf
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT The emergence of bacterial drug resistance poses a severe threat to global public health. In particular, antimicrobial-resistant pathogens lead to a high rate of treatment failure and significantly increase mortality. Repurposing FDA-approve
Externí odkaz:
https://doaj.org/article/1c2c2ee14a7e4545a40b7697b0507484
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
IntroductionAntibiotic resistance has posed a serious challenge to global public health. With the increasing resistance emergence of E. coli and mortality caused by drug-resistant E. coli infections, it is urgent to develop novel antibiotics.MethodsB
Externí odkaz:
https://doaj.org/article/09323c90e42a467ea5a79ae9fbe3d867