Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Pengda Liu"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Ewing sarcoma is a pediatric bone and soft tissue tumor treated with chemotherapy, radiation, and surgery. Despite intensive multimodality therapy, ~50% patients eventually relapse and die of the disease due to chemoresistance. Here, using p
Externí odkaz:
https://doaj.org/article/632cfbc47a004aad8896864418a4d414
Autor:
Zhichuan Zhu, Xin Zhou, Hongwei Du, Erica W. Cloer, Jiaming Zhang, Liu Mei, Ying Wang, Xianming Tan, Austin J. Hepperla, Jeremy M. Simon, Jeanette Gowen Cook, Michael B. Major, Gianpietro Dotti, Pengda Liu
Publikováno v:
Advanced Science, Vol 10, Iss 3, Pp n/a-n/a (2023)
Abstract STING is an innate immune sensor for immune surveillance of viral/bacterial infection and maintenance of an immune‐friendly microenvironment to prevent tumorigenesis. However, if and how STING exerts innate immunity‐independent function
Externí odkaz:
https://doaj.org/article/796291b0707848dcb29d54fda077dfb1
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/4e5067557b6d4430a78d3aa4e548ea6f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The innate immune response is the first-line host defense against pathogens. Cytosolic nucleic acids, including both DNA and RNA, represent a special type of danger signal to initiate an innate immune response. Activation of cytosolic nucleic acid se
Externí odkaz:
https://doaj.org/article/11bca77243e341369ea1ef9a900851f5
Autor:
Le Yu, Pengda Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Abstract Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special asymmetric cyclic-dinucleotide, 2′3′-cGAMP,
Externí odkaz:
https://doaj.org/article/23415e138bc94bc6a4296aee73768c23
Publikováno v:
IEEE Access, Vol 8, Pp 182295-182306 (2020)
In this article, a novel online method for multi-player non-zero-sum (NZS) differential games of nonlinear partially unknown continuous time (CT) systems with control constraints is developed based on neural networks (NN). The issue of multi-player N
Externí odkaz:
https://doaj.org/article/20b7b256f6694715ae265db5d8a3482c
Publikováno v:
Cancers, Vol 15, Iss 2, p 382 (2023)
Ewing sarcoma is the second most common bone tumor in childhood and adolescence. Currently, first-line therapy includes multidrug chemotherapy with surgery and/or radiation. Although most patients initially respond to chemotherapy, recurrent tumors b
Externí odkaz:
https://doaj.org/article/292a015c7c8148ea9f36b170f18ab9a4
Autor:
Jianfeng Chen, Derek L. Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang, Michael J. Emanuele, Nicholas G. Brown, Pengda Liu
Publikováno v:
Cancers, Vol 15, Iss 2, p 517 (2023)
Protein deubiquitinases play critical pathophysiological roles in cancer. Among all deubiquitinases, an oncogenic function for OTUD7B has been established in genetic NSCLC murine models. However, few deubiquitinase inhibitors have been developed due
Externí odkaz:
https://doaj.org/article/cd1e8d8a08574594b8e2f1a4b6bbd92f
Autor:
Siyuan Su, Jianfeng Chen, Yao Jiang, Ying Wang, Tamara Vital, Jiaming Zhang, Christian Laggner, Kong T. Nguyen, Zhichuan Zhu, Alex W. Prevatte, Natalie K. Barker, Laura E. Herring, Ian J. Davis, Pengda Liu
Publikováno v:
Advanced Science, Vol 8, Iss 14, Pp n/a-n/a (2021)
Abstract Chromosomal translocation results in development of an Ewing sarcoma breakpoint region 1‐Friend leukemia integration 1 (EWS–FLI1) fusion oncogene in the majority of Ewing sarcoma. The persistent dependence of the tumor for this oncoprote
Externí odkaz:
https://doaj.org/article/f5749ac898854460840f5c664fe0ca93
Autor:
Yao Jiang, Yanqiong Zhang, Janet Y. Leung, Cheng Fan, Konstantin I. Popov, Siyuan Su, Jiayi Qian, Xiaodong Wang, Alisha Holtzhausen, Eric Ubil, Yang Xiang, Ian Davis, Nikolay V. Dokholyan, Gang Wu, Charles M. Perou, William Y. Kim, H. Shelton Earp, Pengda Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Hyperactivation of Akt promotes tumorigenesis. Here, the authors show that SAV1, a member of Hippo signalling, interacts with Akt to suppress Akt activity and MERTK-mediated Akt phosphorylation relieves this suppression to facilitate Akt oncogenic ac
Externí odkaz:
https://doaj.org/article/b6df3eea370a40a0932a4398891238b5