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Akademický článek
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Publikováno v:
ACS Infectious Diseases. 6:975-985
The emergence and prevalence of carbapenem-resistant bacterial infection have seriously threatened the clinical use of almost all β-lactam antibacterials. The development of effective metallo-β-lactamase (MβL) inhibitors to restore the existing an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::724906e04b5cbe436f9793ec830e6f4b
https://doi.org/10.1021/acsinfecdis.9b00385
https://doi.org/10.1021/acsinfecdis.9b00385
Publikováno v:
Bioconjugate Chemistry. 31:51-63
The traditional antibiotics have specific intracellular targets and disinfect in chemical ways, and the drug-resistance induced by the antibiotics has grown into an emerging threat. It is urgent to...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbce16aef67eecbccb7e022e8996305d
https://doi.org/10.1021/acs.bioconjchem.9b00739
https://doi.org/10.1021/acs.bioconjchem.9b00739
Akademický článek
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Autor:
Ke-Wu Yang, Han Gao, Yin-Sui Xu, Jia-Qi Li, Le Zhai, Huan Wang, Lu Liu, Jia-Zhu Chigan, Peng-Wei Kang
Publikováno v:
Bioorganic chemistry. 114
The expression of β-lactamases, especially metallo-β-lactamases (MβLs) in bacteria is one of the main causes of drug resistance. In this work, an effective N-acylhydrazone scaffold as MβL inhibitor was constructed and characterized. The biologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c710c442cf1cbc5e741cb6d2e93794
https://pubmed.ncbi.nlm.nih.gov/34229201
https://pubmed.ncbi.nlm.nih.gov/34229201
Publikováno v:
ACS infectious diseases. 6(5)
The emergence and prevalence of carbapenem-resistant bacterial infection have seriously threatened the clinical use of almost all β-lactam antibacterials. The development of effective metallo-β-lactamase (MβL) inhibitors to restore the existing an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95bf3be09d38142903a4a56030ce0398
https://pubmed.ncbi.nlm.nih.gov/32119777
https://pubmed.ncbi.nlm.nih.gov/32119777
Publikováno v:
Bioconjugate chemistry. 31(1)
The traditional antibiotics have specific intracellular targets and disinfect in chemical ways, and the drug-resistance induced by the antibiotics has grown into an emerging threat. It is urgent to call for novel strategies and antibacterial material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f38f45803758c83dbb846ddd0e31b48a
https://pubmed.ncbi.nlm.nih.gov/31830418
https://pubmed.ncbi.nlm.nih.gov/31830418
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 142
The bacteria, harboring metallo-β-lactamases (MβLs), become resistant on most β-lactam antibiotics, specifically New Delhi metallo-β-lactamase-1 (NDM-1), which hydrolyzes almost all β-lactam antibiotics leading to bacterial multiple-drug resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5d4d36126b128d76804c221ee2bce9
https://pubmed.ncbi.nlm.nih.gov/31751778
https://pubmed.ncbi.nlm.nih.gov/31751778