Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Peng-Long Li"'
Autor:
Xiao-Ming Wang, Ke Ming, Shuang Wang, Jia Wang, Peng-Long Li, Rui-Feng Tian, Shuai-Yang Liu, Xu Cheng, Yun Chen, Wei Shi, Juan Wan, Manli Hu, Song Tian, Xin Zhang, Zhi-Gang She, Hongliang Li, Yi Ding, Xiao-Jing Zhang
Publikováno v:
Experimental Gerontology, Vol 178, Iss , Pp 112202- (2023)
Skin aging is a complex process involving intricate genetic and environmental factors. In this study, we performed a comprehensive analysis of the transcriptional regulatory landscape of skin aging in canines. Weighted Gene Co-expression Network Anal
Externí odkaz:
https://doaj.org/article/7783c182d7544448aedd861b781f7c0b
Autor:
Zhenya Wang, Wei Shi, Taibo Wu, Tian Peng, Xiaoming Wang, Shuaiyang Liu, Zifeng Yang, Jia Wang, Peng-Long Li, Ruifeng Tian, Ying Hong, Hailong Yang, Lan Bai, Yufeng Hu, Xu Cheng, Hongliang Li, Xiao-Jing Zhang, Zhi-Gang She
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundPathological cardiac hypertrophy is commonly resulted from sustained pressure overload and/or metabolic disorder and eventually leads to heart failure, lacking specific drugs in clinic. Here, we aimed to identify promising anti-hypertrophic
Externí odkaz:
https://doaj.org/article/9dc49f7980384b90a95bcbc593006ced
Autor:
Peng‐Long Li, Mei Li, Zhenya Wang, Xiao‐Ming Wang, Shuai‐Yang Liu, Song Tian, Zhou‐Xiang Wang, Xu Cheng, Yufeng Hu, Peng Zhang, Zhi‐Gang She, Hailong Yang, Hongliang Li, Xiao‐Jing Zhang
Publikováno v:
Obesity. 31:1584-1599
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b19fe136d503749b44844f1dd4a76f5f
https://doi.org/10.1002/oby.23727
https://doi.org/10.1002/oby.23727
Autor:
Juan Yang, Zhi-Gang She, Zan Huang, Hui Liu, Hongliang Li, Lihua Zhu, Hongyu Nie, Hong-Jie Shi, Xiao-Jing Zhang, Ling Li, Yufeng Hu, Zhen Liu, Guo-Peng Chen, Peng-Long Li, Peng Zhang
Publikováno v:
Hypertension. 76:1219-1230
Pathological cardiac hypertrophy is one of the major predictors and inducers of heart failure, the end stage of various cardiovascular diseases. However, the molecular mechanisms underlying pathogenesis of pathological cardiac hypertrophy remain larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b744b4e9b5cbb907013b15da5c2578f3
https://doi.org/10.1161/hypertensionaha.120.14752
https://doi.org/10.1161/hypertensionaha.120.14752
Autor:
Xiao-Jing Zhang, Zhi-Gang She, Junyong Wang, Dating Sun, Li-Jun Shen, Hui Xiang, Xu Cheng, Yan-Xiao Ji, Yong-Ping Huang, Peng-Long Li, Xia Yang, Yanjie Cheng, Jun-Peng Ma, Hai-Ping Wang, Yufeng Hu, Fengjiao Hu, Song Tian, Han Tian, Peng Zhang, Guang-Nian Zhao, Lin Wang, Man-Li Hu, Qin Yang, Li-Hua Zhu, Jingjing Cai, Juan Yang, Xin Zhang, Xinliang Ma, Qingbo Xu, Rhian M. Touyz, Peter P. Liu, Rohit Loomba, Yibin Wang, Hongliang Li
Publikováno v:
Science translational medicine. 13(624)
Lipotoxicity is a recognized pathological trigger and accelerator of nonalcoholic steatohepatitis (NASH). However, the molecular basis of lipotoxicity-induced NASH remains elusive. Here, we systematically mapped the changes in hepatic transcriptomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5431986f0b88f5dd4a7c3139f83772f
https://pubmed.ncbi.nlm.nih.gov/35108509
https://pubmed.ncbi.nlm.nih.gov/35108509
A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques
Autor:
Xiao-Jing Zhang, Yan-Xiao Ji, Xu Cheng, Yanjie Cheng, Hailong Yang, Junyong Wang, Ling-Ping Zhao, Yong-Ping Huang, Dating Sun, Hui Xiang, Li-Jun Shen, Peng-Long Li, Jun-Peng Ma, Rui-Feng Tian, Juan Yang, Xinxin Yao, Haibo Xu, Rufang Liao, Li Xiao, Peng Zhang, Xin Zhang, Guang-Nian Zhao, Xi Wang, Man-Li Hu, Song Tian, Juan Wan, Jingjing Cai, Xinliang Ma, Qingbo Xu, Yibin Wang, Rhian M. Touyz, Peter P. Liu, Rohit Loomba, Zhi-Gang She, Hongliang Li
Publikováno v:
Science Translational Medicine. 13
IMA-1 targets the ALOX12-ACC1 interaction to both prevent and treat NASH without inducing hyperlipidemia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eec455918af91270d701431b811b790b
https://doi.org/10.1126/scitranslmed.abg8116
https://doi.org/10.1126/scitranslmed.abg8116
Autor:
Lin Cai, Jiajun Fu, Jingjing Cai, Yan Zhang, Han Tian, Jun‐ peng Ma, Xi Wang, Ye Liu, Huan Wen, Yutao Wang, Zhi-Gang She, Hongliang Li, Zan Huang, Chang-Ling Zhao, Wenhua Li, Zhu‐feng Dong, Peng-Long Li
Publikováno v:
Hepatology. 71:93-111
Activation of apoptosis signal-regulating kinase 1 (ASK1) is a key driving force of the progression of nonalcoholic steatohepatitis (NASH) and represents an attractive therapeutic target for NASH treatment. However, the molecular and cellular mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a70e72cd6b9696ffca935d26de02e7
https://doi.org/10.1002/hep.30822
https://doi.org/10.1002/hep.30822
Autor:
Yutao Wang, Peng Zhang, Xu Cheng, Song Tian, Yan-Xiao Ji, Lin Cai, Yufeng Hu, Peng-Long Li, Zhi-Gang She, Xiao-Jing Zhang, Lan Bai, Xiaoming Wang, Han Tian, Yufeng Yuan, Hongliang Li, Zhen Liu
Publikováno v:
Cell Metabolism. 33:1171-1186.e9
Antihyperglycemic therapy is an important priority for the treatment of type 2 diabetes (T2D). Excessive hepatic glucose production (HGP) is a major cause of fasting hyperglycemia. Therefore, a better understanding of its regulation would be importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0f296c46def188fc97ce6620ce6d09
https://doi.org/10.1016/j.cmet.2021.04.006
https://doi.org/10.1016/j.cmet.2021.04.006