Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Peng-Hsun Chase Chen"'
Autor:
Peng-Hsun Chase Chen, Xuejiao Shirley Guo, Hanyuan Eric Zhang, Gopal K. Dubey, Zhi Zachary Geng, Carol A. Fierke, Shiqing Xu, J. Trae Hampton, Wenshe Ray Liu
Publikováno v:
ACS Central Science, Vol 10, Iss 4, Pp 782-792 (2024)
Externí odkaz:
https://doaj.org/article/d71941143edf450a9bfc51584dc72d67
Autor:
Jeffery M. Tharp, J. Trae Hampton, Catrina A. Reed, Andreas Ehnbom, Peng-Hsun Chase Chen, Jared S. Morse, Yadagirri Kurra, Lisa M. Pérez, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Most epigenetic regulator inhibitors target tunnels of active sites, rather than the peptide binding groove, leading to concerns with low selectivity. Here the authors use an amber obligate phage library to rapidly identify isoform-selective inhibito
Externí odkaz:
https://doaj.org/article/b1aac1c05c7c4fed851748bbcd7bc307
Autor:
Kaustav Khatua, Yugendar R. Alugubelli, Kai S. Yang, Veerabhadra R. Vulupala, Lauren R. Blankenship, Demonta D. Coleman, Sandeep Atla, Sankar P. Chaki, Zhi Zachary Geng, Xinyu R. Ma, Jing Xiao, Peng-Hsun Chase Chen, Chia-Chuan Dean Cho, Erol C. Vatansever, Yuying Ma, Ge Yu, Benjamin W. Neuman, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
bioRxiv
Main protease (MPro) of SARS-CoV-2, the viral pathogen of COVID-19, is a crucial nonstructural protein that plays a vital role in the replication and pathogenesis of the virus. Its protease function relies on three active site pockets to recognize P1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216a999fb1a67e7463a682d08f991ad5
https://doi.org/10.1101/2023.04.11.536467
https://doi.org/10.1101/2023.04.11.536467
Autor:
Zhi Zachary Geng, Sandeep Atla, Namir Shaabani, Veerabhadra R. Vulupala, Kai S. Yang, Yugendar R. Alugubelli, Kaustav Khatua, Peng-Hsun Chase Chen, Jing Xiao, Lauren R. Blankenship, Xinyu R. Ma, Erol C. Vatansever, Chia-Chuan Cho, Yuying Ma, Robert Allen, Henry Ji, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
bioRxiv
SARS-CoV-2 is the coronavirus pathogen of the currently prevailing COVID-19 pandemic. It relies on its main protease (MPro) for replication and pathogenesis. MProis a demonstrated target for the development of antivirals for SARS-CoV-2. Past studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac78ca035630d56fd9f723ac192834af
https://europepmc.org/articles/PMC9882326/
https://europepmc.org/articles/PMC9882326/
Autor:
Peng-Hsun Chase Chen, Xuejiao Shirley Guo, Hanyuan Eric Zhang, Zhi Zachary Geng, Gopal K. Dubey, Carol A. Fierke, Shiqing Xu, Wenshe Ray Liu
Eleven-nineteen leukemia protein (ENL) plays pivotal roles in the leukemogenesis. As a YEATS domain protein, ENL reads histone acylation marks and recruits key transcription factors to leukemic drivers such asHOXA9, MEIS1, andMYBand therefore promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8011bc08b842f636212162257b403913
https://doi.org/10.1101/2023.01.08.523168
https://doi.org/10.1101/2023.01.08.523168
Autor:
J. Trae Hampton, Chia-Chuan Dean Cho, Zhi Zachary Geng, Demonta D. Coleman, Peng-Hsun Chase Chen, Gopal K. Dubey, Lauralee D. Sylvain, Shiqing Xu, Wenshe Ray Liu
In the past two decades, phage display has emerged as a powerful technique for the identification of antibodies and peptide ligands for therapeutic targets. Using the amber suppression-based noncanonical amino acid (ncAA) mutagenesis approach, we and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::692615a02308800f6244faf2e2def003
https://doi.org/10.1101/2022.12.19.521047
https://doi.org/10.1101/2022.12.19.521047
Autor:
Jared S. Morse, Yan J. Sheng, Joshua Trae Hampton, Lauralee D. Sylvain, Sukant Das, Yugendar R. Alugubelli, Peng‐Hsun Chase Chen, Kai S. Yang, Shiqing Xu, Carol A. Fierke, Wenshe Ray Liu
Publikováno v:
Protein Science. 31
Phage-assisted, active site-directed ligand evolution (PADLE) is a recently developed technique that uses an amber codon-encoded noncanonical amino acid (ncAA) as an anchor to direct phage-displayed peptides to a target for an enhanced ligand identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cefb4d378f01bb20140799625eaa37
https://doi.org/10.1002/pro.4512
https://doi.org/10.1002/pro.4512
Autor:
Jared S. Morse, Yan J. Sheng, J. Trae Hampton, Lauralee D. Sylvain, Sukant Das, Yugendar R. Alugubelli, Peng-Hsun Chase Chen, Kai S. Yang, Shiqing Xu, Carol A. Fierke, Wenshe Ray Liu
The phage-assisted, active site-directed ligand evolution (PADLE) is a recently developed technique that uses an amber codon-encoded noncanonical amino acid (ncAA) as an anchor to direct phage-displayed peptides to a target for an enhanced ligand ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6bd525d84b0b2f9d07d7846bcd96523
https://doi.org/10.1101/2022.09.14.508049
https://doi.org/10.1101/2022.09.14.508049
Autor:
J. Trae Hampton, Duen Shian Wang, Jin Liu, Wenshe R. Liu, Sukant K. Das, Jeffery M. Tharp, Xiaoshan Shayna Wang, Catrina A. Reed, Peng Hsun Chase Chen, Yang Shen, Hamed S. Hayatshahi
Publikováno v:
Angew Chem Int Ed Engl
Superior to linear peptides in biological activities, cyclic peptides are considered to have great potentials used as therapeutic agents. In order to identify cyclic peptide ligands for therapeutic targets, selection from phage-displayed peptide libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb35f4a61f551d4af12876361d84689
https://doi.org/10.1002/anie.201908713
https://doi.org/10.1002/anie.201908713
Autor:
Peng-Hsun Chase Chen, Wenshe R. Liu
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071616161
Methods in Molecular Biology ISBN: 9781071616161
Due to the great potentials of cyclic peptides as therapeutic agents. Several phage-displayed peptide libraries in which cyclization is achieved by the covalent linkage of cysteines have been previously demonstrated to identify cyclic-peptide ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572a83d27f8afced68ed54173ca6a086
https://europepmc.org/articles/PMC8491649/
https://europepmc.org/articles/PMC8491649/