Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Peng Quan Li"'
Autor:
Xin Zhou, Sui-Ning Xu, Shu-Tong Yuan, Xinjuan Lei, Xiaoying Sun, Lu Xing, Hui-Jin Li, Chun-Xia He, Wei Qin, Dong Zhao, Peng-Quan Li, Edward Moharomd, Xuehong Xu, Hui-Ling Cao
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Background Vascular calcification is a closely linked to cardiovascular diseases, such as atherosclerosis, chronic kidney disease, diabetes, hypertension and aging. The extent of vascular calcification is closely correlate with adverse clini
Externí odkaz:
https://doaj.org/article/4aec19a98b2f477e8d73358fb5467143
Autor:
Chun-Xia He, You Lv, Meng Guo, Huan Zhou, Wei Qin, Dong Zhao, Hui-Jin Li, Lu Xing, Xin Zhou, Peng-Quan Li, Feng Yu, Jian-Hua He, Hui-Ling Cao
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
New targeted chemotherapy agents greatly improved five-year survival in NSCLC patients, but which were susceptible to drug resistance. NVP-AUY922, terminated in phase II clinical trials, exhibited promising anti-NSCLC (non-small-cell lung cancer) act
Externí odkaz:
https://doaj.org/article/6a5c920d258e4749ab73270c46c39fdc
Autor:
Wei Qin, Yi-Heng Li, Jing Tong, Jie Wu, Dong Zhao, Hui-Jin Li, Lu Xing, Chun-Xia He, Xin Zhou, Peng-Quan Li, Ge Meng, Shao-Ping Wu, Hui-Ling Cao
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
Atrial fibrillation (AF) is the most common clinical sustained arrhythmia; clinical therapeutic drugs have low atrial selectivity and might cause more severe ventricle arrhythmias while stopping AF. As an anti-AF drug target with high selectivity on
Externí odkaz:
https://doaj.org/article/2db829e780674f2081cff24f16e9cf18
Autor:
Lu Xing, Xin Zhou, Ai-Hong Li, Hui-Jin Li, Chun-Xia He, Wei Qin, Dong Zhao, Peng-Quan Li, Li Zhu, Hui-Ling Cao
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Atherosclerosis is the main pathological basis of cardiovascular diseases and it is closely associated with hyperlipidemia, endothelial injury, macrophage-derived
Externí odkaz:
https://doaj.org/article/c2781799081c48a98d2f3d26c3088c29
Autor:
Dong Zhao, Yi-Ming Xu, Lu-Qi Cao, Feng Yu, Huan Zhou, Wei Qin, Hui-Jin Li, Chun-Xia He, Lu Xing, Xin Zhou, Peng-Quan Li, Xin Jin, Yuan He, Jian-Hua He, Hui-Ling Cao
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
SNX-2112, as a promising anticancer lead compound targeting heat shock protein 90 (Hsp90), absence of complex crystal structure of Hsp90N-SNX-2112 hindered further structural optimization and understanding on molecular interaction mechanism. Herein,
Externí odkaz:
https://doaj.org/article/95556b14c62e4cb088dc85e5a71286a5
Autor:
Wei Qin, Hong-Jie Wu, Lu-Qi Cao, Hui-Jin Li, Chun-Xia He, Dong Zhao, Lu Xing, Peng-Quan Li, Xi Jin, Hui-Ling Cao
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Poly-adenosine diphosphate-ribose polymerase (PARP) implements posttranslational mono- or poly-ADP-ribosylation modification of target proteins. Among the known 18 members in the enormous family of PARP enzymes, several investigations about PARP1, PA
Externí odkaz:
https://doaj.org/article/a6fe09be38484c2a89877d5640e10ac6
Autor:
Lu Xing, Huan Zhou, Qi Sheng Wang, Chun Xia He, Fang Zhou, Feng Yu, Wei Qin, Peng Quan Li, Jianhua He, Xin Zhou, Xi Jin, Hui Ling Cao, Ping Li, Dong Zhao, Hui Jin Li
Publikováno v:
Acta Crystallographica Section D Structural Biology. 77:86-97
Debio0932 is a promising lead compound in phase I clinical trials targeting the N-terminal ATP-binding pocket of the molecular chaperone heat-shock protein 90 (Hsp90N). The absence of a crystal structure of the Hsp90N–Debio0932 complex, however, ha
Autor:
Wei Qin, Yi-Heng Li, Jing Tong, Jie Wu, Dong Zhao, Hui-Jin Li, Lu Xing, Chun-Xia He, Xin Zhou, Peng-Quan Li, Ge Meng, Shao-Ping Wu, Hui-Ling Cao
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
Atrial fibrillation (AF) is the most common clinical sustained arrhythmia; clinical therapeutic drugs have low atrial selectivity and might cause more severe ventricle arrhythmias while stopping AF. As an anti-AF drug target with high selectivity on
Autor:
Long Li, Xing-Li Su, Tian-Tian Bai, Wei Qin, Ai-Hong Li, Yang-Xin Liu, Ming Wang, Jiang-Kai Wang, Lu Xing, Hui-Jin Li, Chun-Xia He, Xin Zhou, Dong Zhao, Peng-Quan Li, Shao-Ping Wu, Jian-Li Liu, Yu-Long Chen, Hui-Ling Cao
Publikováno v:
European Journal of Pharmacology. 927:175057
Hypertension is a major risk factor for cardiovascular disease and Chinese herb monomers could provide new structural skeletons for anti-hypertension new drug development. Paeonol is a Chinese herbal monomer extracted from Cortex moutan, exhibited so
Autor:
Hui-Jin, Li, Qi-Sheng, Wang, Wen, Han, Huan, Zhou, Ping, Li, Fang, Zhou, Wei, Qin, Dong, Zhao, Xin, Zhou, Chun-Xia, He, Lu, Xing, Peng-Quan, Li, Xi, Jin, Feng, Yu, Jian-Hua, He, Hui-Ling, Cao
Publikováno v:
Journal of structural biology. 213(2)
KW-2478 is a promising anti-cancer lead compound targeting to the molecular chaperone heat shock protein 90