Improved Anticancer Activities of a New Pentafluorothio-Substituted Vorinostat-Type Histone Deacetylase Inhibitor

Autor: Goehringer, Nils, Peng, Yayi, Nitzsche, Bianca, Biermann, Hannah, Pradhan, Rohan, Schobert, Rainer, Herling, Marco, Höpfner, Michael, Biersack, Bernhard

The development of new anticancer drugs is necessary in order deal with the disease and with the drawbacks of currently applied drugs. Epigenetic dysregulations are a central hallmark of cancerogenesis and histone deacetylases (HDACs) emerged as prom

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Optimizing drug combinations for T-PLL: restoring DNA damage and P53-mediated apoptotic responses

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Publikováno v: In Blood 10 October 2024 144(15):1595-1610

Dual T-cell constant β chain (TRBC)1 and TRBC2 staining for the identification of T-cell neoplasms by flow cytometry.

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Publikováno v: Blood Cancer Journal; 2/29/2024, Vol. 14 Issue 1, p1-11, 11p

Improved Anticancer Activities of a New Pentafluorothio-Substituted Vorinostat-Type Histone Deacetylase Inhibitor.

Autor: Goehringer N; Institute of Physiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany., Peng Y; Laboratory of Lymphocyte Signaling and Oncoproteome, University Hospital Cologne, Weyertal 115c, 50931 Cologne, Germany., Nitzsche B; Institute of Physiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany., Biermann H; Institute of Physiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany., Pradhan R; Care Group Sight Solution Pvt. Ltd., Dabhasa, Vadodara 391440, India., Schobert R; Organic Chemistry 1, University of Bayreuth, Universitätsstraße 30, 95440 Bayreuth, Germany., Herling M; Laboratory of Lymphocyte Signaling and Oncoproteome, University Hospital Cologne, Weyertal 115c, 50931 Cologne, Germany.; Clinic and Polyclinic for Hematology, Cell Therapy and Hemostaseology, Liebigstraße 22, House 7, 04103 Leipzig, Germany., Höpfner M; Institute of Physiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany., Biersack B; Organic Chemistry 1, University of Bayreuth, Universitätsstraße 30, 95440 Bayreuth, Germany.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2021 Dec 17; Vol. 14 (12). Date of Electronic Publication: 2021 Dec 17.