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Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct.

Autor: de Guglielmo G; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Carrette L; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Kallupi M; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Brennan M; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Boomhower B; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Maturin L; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Conlisk D; Department of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, United States., Sedighim S; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Tieu L; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Fannon MJ; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Martinez AR; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Velarde N; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Othman D; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Sichel B; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Ramborger J; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Lau J; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Kononoff J; Department of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, United States., Kimbrough A; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Simpson S; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Smith LC; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Department of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, United States., Shankar K; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Department of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, United States., Bonnet-Zahedi S; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Institut de Neurosciences de la Timone, Aix-Marseille Université, Marseille, France., Sneddon EA; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Avelar A; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Department of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, United States., Plasil SL; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Mosquera J; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Crook C; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Chun L; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Vang A; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Milan KK; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Schweitzer P; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Lin B; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Peng B; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Chitre AS; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Polesskaya O; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States., Solberg Woods LC; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, United States., Palmer AA; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States., George O; Department of Psychiatry, University of California, San Diego, La Jolla, United States.

Publikováno v: ELife [Elife] 2024 Nov 01; Vol. 12. Date of Electronic Publication: 2024 Nov 01.

Discovery of optimal cell type classification marker genes from single cell RNA sequencing data.

Autor: Liu A; Department of Informatics, J. Craig Venter Institute, La Jolla, CA, United States of America., Peng B; Department of Informatics, J. Craig Venter Institute, La Jolla, CA, United States of America., Pankajam AV; Intramural Research Program, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States of America., Duong TE; Department of Pediatrics, Division of Respiratory Medicine, University of California, San Diego, La Jolla, CA, United States of America., Pryhuber G; Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, United States of America., Scheuermann RH; Intramural Research Program, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States of America., Zhang Y; Department of Informatics, J. Craig Venter Institute, La Jolla, CA, United States of America.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 26. Date of Electronic Publication: 2024 Jun 26.