Zobrazeno 1 - 10 of 352 pro vyhledávání: '"Penetrant (biochemical)"'
2
N-Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors
Autor: Sung Ok Yoon, Yangbo Feng, HaJeung Park, Jae Cheon Ryu
Publikováno v: ACS Med Chem Lett
[Image: see text] An indazole/aza-indazole scaffold was developed as a novel chemotype for JNK3 inhibition. Extensive structure activity relationship (SAR) studies utilizing various in vitro and in vivo assays led to potent and highly selective JNK3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1ed6f7cc06fbaceb5c1c9f8d5888f0
https://doi.org/10.1021/acsmedchemlett.1c00334
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4
A Novel Mutation of the Membrane Metallo-Endopeptidase Gene Related to Late-Onset Hereditary Polyneuropathy: Case Report and Review of the Literature
Autor: Konstantinos I. Tsamis, Alexandros Giannakis, Ioannis Sarmas, Ilias P. Nikas, Georgia Xiromerisiou, Spiridon Konitsiotis
Publikováno v: Laboratory Medicine. 53:210-214
The advent of next generation sequencing has revolutionized diagnostic approaches to hereditary polyneuropathies. Recently, mutations on the membrane metallo-endopeptidase (MME) gene, encoding neprilysin, have been related to the development of late-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a4b103d824ce64e3e23006022ef768
https://doi.org/10.1093/labmed/lmab060
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5
Potential Landscape of a Probe Penetrant Particle for Fast Estimating of Silica Diffusion Properties
Autor: Sergey V. Kukhtetskiy
Publikováno v: Journal of Siberian Federal University. Chemistry. 14:406-417
Successful search for optimal molecular structures of membrane materials requires efficient algorithms for assessing their diffusion properties. It is shown in this work that the potential landscape of a probe penetrating particle, a component that p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4e4bda44761c078d5cf49189722d50e
https://doi.org/10.17516/1998-2836-0250
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6
Utility and Diversity: Challenges for Genomic Medicine
Autor: Wylie Burke
Publikováno v: Annual Review of Genomics and Human Genetics. 22:1-24
Genomic information is poised to play an increasing role in clinical care, extending beyond highly penetrant genetic conditions to less penetrant genotypes and common disorders. But with this shift, the question of clinical utility becomes a major ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3297cd6b15c245e365ff2aa9812cf4b
https://doi.org/10.1146/annurev-genom-120220-082640
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7
Bioavailability and pharmacokinetic profile of balovaptan, a selective, brain-penetrant vasopressin 1a receptor antagonist, in healthy volunteers
Autor: Michael Derks, Christoph Wandel, Sian Lennon-Chrimes, Axel Paehler, Piotr Szczesny, Heidemarie Kletzl, Lisa Squassante, Andreas Guenther
Publikováno v: Expert Opinion on Investigational Drugs. 30:893-901
Balovaptan is a potent, selective vasopressin 1a receptor antagonist. The early-phase pharmacokinetics (PK) of balovaptan are reported.Two Phase 1 studies (overallAbsolute balovaptan bioavailability was high (103-116%). Steady-state (Day 14) balovapt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594453fb8d9e29e6cd63b0245011308f
https://doi.org/10.1080/13543784.2021.1948009
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