Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Penelope N. Markham"'
Autor:
Alex A. Neyfakh, Penelope N. Markham
Publikováno v:
Current Opinion in Microbiology. 4:509-514
Gram-positive bacteria express numerous membrane transporters that promote the efflux of various drugs, including many antibiotics, from the cell to the outer medium. Drug transporters can be specific to a particular drug, or can have broad specifici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df600e2207ff9d29f2645bf61994f11e
https://doi.org/10.1016/s1369-5274(00)00243-5
https://doi.org/10.1016/s1369-5274(00)00243-5
Publikováno v:
Transplantation. 62:1883-1888
Natural killer (NK) cells are the first lymphoid population to reconstitute the peripheral blood compartment of immunologically compromised bone marrow transplant (BMT) recipients. Recent data suggest that, among patients transplanted for leukemia, N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::becd5504920946406dbcbcf8521ad656
https://doi.org/10.1097/00007890-199612270-00035
https://doi.org/10.1097/00007890-199612270-00035
Publikováno v:
Journal of Bacteriology. 177:3904-3910
The Bacillus subtilis genome encodes two multidrug efflux transporters sharing 51% sequence identity: Bmr, described previously, and Blt, described here. Overexpression of either transporter in B. subtilis leads to a similar increase in resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e206dfdb1549c08fe25e0a0d28d805a
https://doi.org/10.1128/jb.177.14.3904-3910.1995
https://doi.org/10.1128/jb.177.14.3904-3910.1995
Autor:
Eitan Bibi, Penelope N. Markham, Richard G. Brennan, Ekaterina E. Zheleznova, Rotem Edgar, Alexander A. Neyfakh
Publikováno v:
Trends in biochemical sciences. 25(2)
Multidrug transporters bind chemically dissimilar, potentially cytotoxic compounds and remove them from the cell. How these transporters carry out either of these functions is unknown. On the basis of crystal structures of the multidrug-binding domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46943441e1077fa27451c35ede8286f3
https://pubmed.ncbi.nlm.nih.gov/10664577
https://pubmed.ncbi.nlm.nih.gov/10664577
Publikováno v:
Biochemistry. 38(51)
The Bacillus subtilis transcriptional regulator BmrR recognizes dissimilar hydrophobic cations and, in response, activates the expression of a multidrug transporter which expels them out of the cell. The structure of the inducer-binding domain of Bmr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e776124f7bbede22d0196bd9c968904f
https://pubmed.ncbi.nlm.nih.gov/10606527
https://pubmed.ncbi.nlm.nih.gov/10606527
Publikováno v:
Cell. 96(3)
Multidrug-efflux transporters demonstrate an unusual ability to recognize multiple structurally dissimilar toxins. A comparable ability to bind diverse hydrophobic cationic drugs is characteristic of the Bacillus subtilis transcription regulator BmrR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4668074225b1db21ba8fa45e346a7f85
https://pubmed.ncbi.nlm.nih.gov/10025401
https://pubmed.ncbi.nlm.nih.gov/10025401
Publikováno v:
Human immunology. 59(8)
Patients presenting with a natural killer (NK) cell leukemia generally have a poor prognosis. NK cell tumors are generally resistant to numerous chemotherapeutic drugs and even combination chemotherapy usually results in only short term remissions. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fb23eaa07745d3400c0261bc7367a1
https://pubmed.ncbi.nlm.nih.gov/9712351
https://pubmed.ncbi.nlm.nih.gov/9712351
Publikováno v:
Protein science : a publication of the Protein Society. 6(11)
In the bacterium Bacillus subtilis, the DNA-binding regulatory protein, BmrR, activates transcription from the multidrug transporter gene, bmr, after binding either rhodamine or tetraphenylphosphonium. These two compounds, which have no structural si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36b60888a4fefe25f00c3dcb817d16e
https://pubmed.ncbi.nlm.nih.gov/9385651
https://pubmed.ncbi.nlm.nih.gov/9385651
Publikováno v:
Biochemical and biophysical research communications. 239(1)
The expression of the Bacillus subtilus multidrug-efflux transporter Bmr can be induced by two of its structurally dissimilar substrates, rhodamine 6G and tetraphenylphosphonium, through their direct interaction with the transcriptional regulator Bmr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7415ff86e17b96a5e21e6d91ee56cdcc
https://pubmed.ncbi.nlm.nih.gov/9345308
https://pubmed.ncbi.nlm.nih.gov/9345308
Autor:
Mathieu Chevalier, Nora Vázquez-Laslop, Penelope N. Markham, Dale P. Woolridge, Eugene W. Gerner, Alexander A. Neyfakh
Publikováno v:
The Journal of biological chemistry. 272(14)
Multidrug transporters pump structurally dissimilar toxic molecules out of cells. It is not known, however, if detoxification is the primary physiological function of these transporters. The chromosomal organization of the gene encoding the Bacillus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc9b00e9f22d2633ca84520b0345357
https://pubmed.ncbi.nlm.nih.gov/9083003
https://pubmed.ncbi.nlm.nih.gov/9083003