Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Penelope J. Duerksen-Hughes"'
Autor:
William A. Chen, Terry G. Williams, Leena So, Natalie Drew, Jie Fang, Pedro Ochoa, Nhi Nguyen, Yasmeen Jawhar, Jide Otiji, Penelope J. Duerksen-Hughes, Mark E. Reeves, Carlos A. Casiano, Hongjian Jin, Sinisa Dovat, Jun Yang, Kristopher E. Boyle, Olivia L. Francis-Boyle
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4342 (2024)
Acute myeloid leukemia (AML) is a hematological malignancy that is characterized by an expansion of immature myeloid precursors. Despite therapeutic advances, the prognosis of AML patients remains poor and there is a need for the evaluation of promis
Externí odkaz:
https://doaj.org/article/77dd63a5b87a415a97c2d18f5b5c255e
Autor:
Lennox Chitsike, Antonella Bertucci, Marcelo Vazquez, Steve Lee, Juli J. Unternaehrer, Penelope J. Duerksen-Hughes
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionTreatment-related toxicity following either chemo- or radiotherapy can create significant clinical challenges for HNSCC cancer patients, particularly those with HPV-associated oropharyngeal squamous cell carcinoma. Identifying and charact
Externí odkaz:
https://doaj.org/article/5134a13a80664b0fb6810bcf1f1d0b6a
Autor:
Meghri Katerji, Antonella Bertucci, Valery Filippov, Marcelo Vazquez, Xin Chen, Penelope J. Duerksen-Hughes
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
High-risk human papillomaviruses (HPVs) cause virtually all cervical cancer cases and are also associated with other types of anogenital and oropharyngeal cancers. Normally, HPV exists as a circular episomal DNA in the infected cell. However, in some
Externí odkaz:
https://doaj.org/article/0fd2b2e7f9b44380bb3c279ddbf9d172
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The treatment landscape of locally advanced HPV-oropharyngeal squamous cell carcinoma (OPSCC) is undergoing transformation. This is because the high cures rates observed in OPSCC are paired with severe treatment-related, long-term toxicities. These s
Externí odkaz:
https://doaj.org/article/06a911b158f54aeb98272cc5c1177d33
Autor:
Sonia N. Whang, Vivek D. Shah, Lu Pu, Parthiv Sheth, Gina N. Lucas, Joanne Lee, Michael Lee, Curtis Lacy, Penelope J. Duerksen-Hughes, Valeri Filippov, David J. H. Lee, Jennifer Veltman, Kanwaljeet Maken, Mark E. Reeves, Wesley Tait Stevens, Paul Herrmann, Huynh Cao, Eric Lau
Publikováno v:
Pathogens, Vol 11, Iss 9, p 958 (2022)
Background: High-titer convalescent plasma given early for COVID-19 may decrease progression into a severe infection. Here, we reported a study of serial antibody measurements in patients who received CP at our center and performed a systematic revie
Externí odkaz:
https://doaj.org/article/d9aa9045872f41df92dcc0810d4c6322
Publikováno v:
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2021 (2021)
The COVID-19 pandemic that began in late 2019 continues with new challenges arising due to antigenic drift as well as individuals who cannot or choose not to take the vaccine. There is therefore an urgent need for additional therapies that complement
Externí odkaz:
https://doaj.org/article/d6e879b16c5548e1968b728e0cc242cb
Publikováno v:
Molecules, Vol 26, Iss 10, p 3004 (2021)
Advanced cervical cancer is primarily managed using cytotoxic therapies, despite evidence of limited efficacy and known toxicity. There is a current lack of alternative therapeutics to treat the disease more effectively. As such, there have been more
Externí odkaz:
https://doaj.org/article/969a8eaa9d2c4ff1ac16ac90808742d9
Autor:
Valery Filippov, Karen Jaceldo-Siegl, Alexey Eroshkin, Vasiliy Loskutov, Xin Chen, Charles Wang, Penelope J. Duerksen-Hughes
Publikováno v:
Epigenomes, Vol 4, Iss 4, p 28 (2020)
Epigenetic studies in animal models have demonstrated that diet affects gene regulation by altering methylation patterns. We interrogated methylomes in humans who have different sources of protein in their diet. We compared methylation of DNA isolate
Externí odkaz:
https://doaj.org/article/f4cecb26cc714c58a31cea3e684dab7e
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-17 (2021)
Virology Journal
Virology Journal
The COVID-19 pandemic has put healthcare infrastructures and our social and economic lives under unprecedented strain. Effective solutions are needed to end the pandemic while significantly lessening its further impact on mortality and social and eco
Autor:
Penelope J. Duerksen-Hughes, Lennox Chitsike, Chung-Hsiang Yuan, Kristopher E. Boyle, Anuradha Roy
Publikováno v:
Oncotarget. 12:549-561
The incidence of human papillomavirus-positive head and neck squamous cell carcinoma (HPV+-HNSCC) has increased dramatically over the past decades due to an increase in infection of the oral mucosa by HPV. The etiology of HPV+-HNSCC is linked to expr