Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Penelope J, Hallett"'
Autor:
Ria Thomas, Kyle J. Connolly, Oeystein R. Brekk, Anthony J. Hinrich, Michelle L. Hastings, Ole Isacson, Penelope J. Hallett
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Inflammatory processes and mechanisms are of central importance in neurodegenerative diseases. In the brain, α-synucleinopathies such as Parkinson’s disease (PD) and Lewy body dementia (LBD) show immune cytokine network activation and inc
Externí odkaz:
https://doaj.org/article/19fde4928a4f45e5b0fc284e1cba2d1f
Autor:
Kyle J. Connolly, Juliette Margaria, Erika Di Biase, Oliver Cooper, Penelope J. Hallett, Ole Isacson
Publikováno v:
Cells, Vol 12, Iss 21, p 2564 (2023)
Tightly regulated and highly adaptive lipid metabolic and transport pathways are critical to maintaining brain cellular lipid homeostasis and responding to lipid and inflammatory stress to preserve brain function and health. Deficits in the lipid han
Externí odkaz:
https://doaj.org/article/7a93c32a9bb34f7aab6684bf664fee10
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-12 (2021)
Abstract Lysosomal dysfunction is a central pathway associated with Parkinson’s disease (PD) pathogenesis. Haploinsufficiency of the lysosomal hydrolase GBA (encoding glucocerebrosidase (GCase)) is one of the largest genetic risk factors for develo
Externí odkaz:
https://doaj.org/article/f1e4acd91f9f4b089c79f0c636b6d006
Autor:
Joanna A. Korecka, Ria Thomas, Anthony J. Hinrich, Alyssa M. Moskites, Zach K. Macbain, Penelope J. Hallett, Ole Isacson, Michelle L. Hastings
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 623-635 (2020)
Parkinson’s disease (PD) is a progressive neurological disorder estimated to affect 7–10 million people worldwide. There is no treatment available that cures or slows the progression of PD. Elevated leucine-rich repeat kinase 2 (LRRK2) activity h
Externí odkaz:
https://doaj.org/article/c35d1d9940544cb3b606f79c91e2929b
Autor:
Oeystein R. Brekk, Joanna A. Korecka, Cecile C. Crapart, Mylene Huebecker, Zachary K. MacBain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A. Priestman, Frances M. Platt, Ole Isacson, Penelope J. Hallett
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Sandhoff disease (SD) is a lysosomal storage disease, caused by loss of β-hexosaminidase (HEX) activity resulting in the accumulation of ganglioside GM2. There are shared features between SD and Parkinson’s disease (PD). α-synuclein (aSY
Externí odkaz:
https://doaj.org/article/a6679db376524eaf95dfb742563c7bce
Autor:
Mylene Huebecker, Elizabeth B. Moloney, Aarnoud C. van der Spoel, David A. Priestman, Ole Isacson, Penelope J. Hallett, Frances M. Platt
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-21 (2019)
Abstract Background Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson’s disease (PD). Recently, more than fifty other lysosomal s
Externí odkaz:
https://doaj.org/article/8a3bdc7450e34016b365323d7a34ab17
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract This article describes pathogenic concepts and factors, in particular glycolipid abnormalities, that create cell dysfunction and synaptic loss in neurodegenerative diseases. By phenocopying lysosomal storage disorders, such as Gaucher diseas
Externí odkaz:
https://doaj.org/article/723f5fe59ef4435eb1d40b735cd6d9f3
Autor:
Joanna A. Korecka, Sebastien Talbot, Teresia M. Osborn, Sherida M. de Leeuw, Simon A. Levy, Eliza J. Ferrari, Alyssa Moskites, Elise Atkinson, Francine M. Jodelka, Anthony J. Hinrich, Michelle L. Hastings, Clifford J. Woolf, Penelope J. Hallett, Ole Isacson
Publikováno v:
Stem Cell Reports, Vol 12, Iss 1, Pp 29-41 (2019)
Summary: The Parkinson disease (PD) genetic LRRK2 gain-of-function mutations may relate to the ER pathological changes seen in PD patients at postmortem. Human induced pluripotent stem cell (iPSC)-derived neurons with the PD pathogenic LRRK2 G2019S m
Externí odkaz:
https://doaj.org/article/872a0bc4898b44ba96fb040e2470c7bb
Publikováno v:
Neurobiology of Disease, Vol 120, Iss , Pp 1-11 (2018)
GPNMB is a glycoprotein observed upon tissue damage and inflammation and is associated with astrocytes, microglia, and macrophages. Gene variations in GPNMB are linked with Parkinson's disease (PD) risk, and changes in protein levels of GPNMB have be
Externí odkaz:
https://doaj.org/article/e45ebeff7e3043fdb4b68922daac954b
Autor:
Manoj Kumar, Manasa P Srikanth, Michela Deleidi, Penelope J Hallett, Ole Isacson, Ricardo A Feldman
Publikováno v:
Human molecular genetics 32(11), 1888-1900 (2023). doi:10.1093/hmg/ddad025
Bi-allelic mutations in GBA1, the gene that encodes β-glucocerebrosidase (GCase), cause Gaucher disease (GD), whereas mono-allelic mutations do not cause overt pathology. Yet mono- or bi-allelic GBA1 mutations are the highest known risk factor for P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e623d80d2d569f3311782fe53a2d787
https://doi.org/10.1093/hmg/ddad025
https://doi.org/10.1093/hmg/ddad025