Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Penelope C. Kay-Fedorov"'
Autor:
Claudia Pokoyski, Wiebke Baars, Mark Windheim, Thomas F. Reubold, Jasmin Zischke, Antje Brinkmann, Penelope C. Kay-Fedorov, Reinhard Schwinzer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Transgenic expression of protective molecules in porcine cells and tissues is a promising approach to prevent xenograft rejection. Viruses have developed various strategies to escape the host’s immune system. We generated porcine B cells (
Externí odkaz:
https://doaj.org/article/12793a81b1ea49b0b6bc28041c5cf640
Autor:
Samuel A. Osanyinlusi, Jasmin Zischke, Roland Jacobs, Eva M. Weissinger, Thomas F. Schulz, Penelope C. Kay-Fedorov
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Human cytomegalovirus (HCMV) encodes numerous immunomodulatory genes that facilitate its persistence. Previously described mechanisms by which HCMV avoids T cell control typically involve evasion of detection by infected cells. Here, we show
Externí odkaz:
https://doaj.org/article/42445613661841e9b5ae0eda0c49a031
Autor:
Nicolás M. Suárez, Tina Ganzenmueller, Jasper Götting, Andrew J. Davison, Akshay Dhingra, Thomas F. Schulz, Jasmin Zischke, Penelope C. Kay-Fedorov, Eva M. Weissinger, P R Varanasi, Albert Heim, Lars Steinbrueck, Salvatore Camiolo
Publikováno v:
Medical Microbiology and Immunology
Human cytomegalovirus (HCMV) is an important opportunistic pathogen in allogeneic haematopoietic stem cell transplant (HSCT) recipients. High-throughput sequencing of target-enriched libraries was performed to characterise the diversity of HCMV strai
Autor:
Jasmin Zischke, Panagiota Mamareli, Claudia Pokoyski, Ildar Gabaev, Sabine Buyny, Roland Jacobs, Christine S Falk, Matthias Lochner, Tim Sparwasser, Thomas F Schulz, Penelope C Kay-Fedorov
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006454 (2017)
Human Cytomegalovirus (HCMV) is a widespread pathogen, infection with which can cause severe disease for immunocompromised individuals. The complex changes wrought on the host's immune system during both productive and latent HCMV infection are well
Externí odkaz:
https://doaj.org/article/89876fd1abc04f9bbd1d91407395d7a5
Autor:
Ildar Gabaev, Lars Steinbrück, Claudia Pokoyski, Andreas Pich, Richard J Stanton, Reinhard Schwinzer, Thomas F Schulz, Roland Jacobs, Martin Messerle, Penelope C Kay-Fedorov
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002432 (2011)
Human cytomegalovirus (CMV) exerts diverse and complex effects on the immune system, not all of which have been attributed to viral genes. Acute CMV infection results in transient restrictions in T cell proliferative ability, which can impair the con
Externí odkaz:
https://doaj.org/article/0cb876d627b3413fb328cb0e678021eb
Autor:
Albert Heim, Thomas F. Schulz, Silvia Linnenweber-Held, Tina Ganzenmueller, Andrew J. Davison, Julius J Schmidt, Elias Hage, Anke Schwarz, Nicolás M. Suárez, Gavin S. Wilkie, Eva Mischak-Weissinger, Penelope C. Kay-Fedorov, Akshay Dhingra
Publikováno v:
The Journal of Infectious Diseases. 215:1673-1683
Background Advances in next-generation sequencing (NGS) technologies allow comprehensive studies of genetic diversity over the entire genome of human cytomegalovirus (HCMV), a significant pathogen for immunocompromised individuals. Methods Next-gener
Autor:
Penelope C. Kay-Fedorov, Nicolás M. Suárez, Thomas F. Schulz, Jasmin Zischke, Tina Ganzenmueller, P Varanasi, Albert Heim, Andrew J. Davison, Eva Mischak-Weissinger, Akshay Dhingra
Publikováno v:
Virus Evolution
Next-generation sequencing (NGS) produces comprehensive insights across the entire genome of the human cytomegalovirus (HCMV), which is an important opportunistic pathogen following hematopoietic stem cell transplantation (HSCT). To assess the clinic
Autor:
Svetlana Tishchenko, Dietmar J. Manstein, Jan Lohöfener, Roman Fedorov, Nicola Steinke, Penelope C. Kay-Fedorov, P. Baruch, Alexey D. Nikulin
Publikováno v:
Structure. 23(5):851-862
Summary2′-5′-Oligoadenylate synthetases (OASs) produce the second messenger 2′-5′-oligoadenylate, which activates RNase L to induce an intrinsic antiviral state. We report on the crystal structures of catalytic intermediates of OAS1 including
Publikováno v:
Viruses
Viruses, Vol 7, Iss 3, Pp 1540-1557 (2015)
Viruses, Vol 7, Iss 3, Pp 1540-1557 (2015)
The receptor tyrosine phosphatase CD45 is expressed on the surface of almost all cells of hematopoietic origin. CD45 functions are central to the development of T cells and determine the threshold at which T and B lymphocytes can become activated. Gi
Autor:
Tim Sparwasser, Claudia Pokoyski, Thomas F. Schulz, Christine S. Falk, Jasmin Zischke, Penelope C. Kay-Fedorov, Ildar Gabaev, Panagiota Mamareli, Sabine Buyny, Matthias Lochner, Roland Jacobs
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 6, p e1006454 (2017)
PLoS Pathogens, Vol 13, Iss 6, p e1006454 (2017)
Human Cytomegalovirus (HCMV) is a widespread pathogen, infection with which can cause severe disease for immunocompromised individuals. The complex changes wrought on the host’s immune system during both productive and latent HCMV infection are wel