A first-in-human study of the novel HIV-fusion inhibitor C34-PEG4-Chol

Autor: Quinn, K, Traboni, C, Dily Penchala, S, Bouliotis, G, Doyle, N, Libri, V, Khoo, S, Ashby, D, Weber, J, Nicosia, A, Cortese, R, Pessi, A, Winston, A

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)

Long-acting injectable antiretroviral (LA-ARV) drugs with low toxicity profiles and propensity for drug-drug interactions are a goal for future ARV regimens. C34-PEG4-Chol is a novel cholesterol tagged LA HIV-fusion-inhibitor (FI). We assessed pre-cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7bb4bec3f2d16aed6036f0392f5a4632
http://hdl.handle.net/11588/746607

Dose finding study for on-demand HIV pre-exposure prophylaxis for insertive sex in sub-Saharan Africa: results from the CHAPS open label randomised controlled trial.

Autor: Herrera C; Department of Infectious Disease, Faculty of Medicine, Imperial College London, Norfolk Place, W2 1PG, London, UK., Serwanga J; Medical Research Council/Uganda Virus Research Institute, and London School of Hygiene and Tropical Medicine, Uganda Research Unit, 51-59 Nakiwogo Road, Entebbe, Uganda., Else L; Department of Molecular and Clinical Pharmacology, William Henry Duncan Building, University of Liverpool, 6 West Derby Street, Liverpool, L7 8TX, UK., Limakatso L; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa; Africa Health Research Unit, Durban, South Africa., Opoka D; Medical Research Council/Uganda Virus Research Institute, and London School of Hygiene and Tropical Medicine, Uganda Research Unit, 51-59 Nakiwogo Road, Entebbe, Uganda., Ssemata AS; Medical Research Council/Uganda Virus Research Institute, and London School of Hygiene and Tropical Medicine, Uganda Research Unit, 51-59 Nakiwogo Road, Entebbe, Uganda; Department of Global Health and Development, London School of Hygiene & Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, UK., Pillay AD; Division of Immunology, University of Cape Town, South Africa based at Respiratory and Meningeal Pathogens Research Unit (RMPRU). Chris Hani Baragwanath Hospital, 30 Chris Hani Road, Diepkloof, Soweto, 1862, South Africa., Namubiru P; Medical Research Council/Uganda Virus Research Institute, and London School of Hygiene and Tropical Medicine, Uganda Research Unit, 51-59 Nakiwogo Road, Entebbe, Uganda., Seiphetlo TB; Division of Immunology, University of Cape Town, South Africa based at Respiratory and Meningeal Pathogens Research Unit (RMPRU). Chris Hani Baragwanath Hospital, 30 Chris Hani Road, Diepkloof, Soweto, 1862, South Africa., Odoch G; Medical Research Council/Uganda Virus Research Institute, and London School of Hygiene and Tropical Medicine, Uganda Research Unit, 51-59 Nakiwogo Road, Entebbe, Uganda., Mugaba S; Medical Research Council/Uganda Virus Research Institute, and London School of Hygiene and Tropical Medicine, Uganda Research Unit, 51-59 Nakiwogo Road, Entebbe, Uganda., Seatlholo P; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa; Africa Health Research Unit, Durban, South Africa., Alieu A; Department of Molecular and Clinical Pharmacology, William Henry Duncan Building, University of Liverpool, 6 West Derby Street, Liverpool, L7 8TX, UK., Penchala SD; Department of Molecular and Clinical Pharmacology, William Henry Duncan Building, University of Liverpool, 6 West Derby Street, Liverpool, L7 8TX, UK., Muhumuza R; Medical Research Council/Uganda Virus Research Institute, and London School of Hygiene and Tropical Medicine, Uganda Research Unit, 51-59 Nakiwogo Road, Entebbe, Uganda., Alinde B; Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Department of Pathology, University of Cape Town, Cape Town, South Africa., Petkov S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solnavägen 9, 171 65 Solna, Sweden., O'Hagan K; Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Department of Pathology, University of Cape Town, Cape Town, South Africa., Callebaut C; Gilead Sciences, Foster City, CA 94404, USA., Seeley J; Department of Global Health and Development, London School of Hygiene & Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, UK; Medical Research Council/Uganda Virus Research Institute, and London School of Hygiene and Tropical Medicine, Uganda Research Unit, 51-59 Nakiwogo Road, Entebbe, Uganda., Weiss H; MRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK., Khoo S; Department of Molecular and Clinical Pharmacology, William Henry Duncan Building, University of Liverpool, 6 West Derby Street, Liverpool, L7 8TX, UK., Chiodi F; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solnavägen 9, 171 65 Solna, Sweden., Gray CM; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Biomedical Research Institute, Stellenbosch University (Tygerberg Campus), Francie van Zijl Drive, Tygerberg, Cape Town, South Africa., Kaleebu P; Medical Research Council/Uganda Virus Research Institute, and London School of Hygiene and Tropical Medicine, Uganda Research Unit, 51-59 Nakiwogo Road, Entebbe, Uganda., Webb EL; MRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK., Martinson N; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa; Africa Health Research Unit, Durban, South Africa; Johns Hopkins University Center for TB Research, Baltimore, MD, USA., Fox J; Infection and Immunity, Borough Wing, Guys and St Thomas' NHS Foundation Trust and King's College London, St. Thomas Street, SE1 9RS, London, UK. Electronic address: Julie.fox@kcl.ac.uk.

Publikováno v: EBioMedicine [EBioMedicine] 2023 Jul; Vol. 93, pp. 104648. Date of Electronic Publication: 2023 Jun 14.

Pre-Clinical Evaluation of Tenofovir and Tenofovir Alafenamide for HIV-1 Pre-Exposure Prophylaxis in Foreskin Tissue.

Autor: Else L; Bioanalytical Facility, Molecular and Clinical Pharmacology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7BE, UK., Penchala SD; Bioanalytical Facility, Molecular and Clinical Pharmacology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7BE, UK., Pillay AD; Division of Immunology, University of Cape Town, Cape Town 7935, South Africa., Seiphetlo TB; Division of Immunology, University of Cape Town, Cape Town 7935, South Africa., Lebina L; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa., Callebaut C; Gilead Sciences, Foster City, CA 94404, USA., Minhas S; Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UK., Morley R; Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UK., Rashid T; Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UK., Martinson N; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa., Fox J; Guys and St. Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, UK., Khoo S; Bioanalytical Facility, Molecular and Clinical Pharmacology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7BE, UK., Herrera C; Department of Infectious Diseases, Faculty of Medicine, Imperial College, London W2 1PG, UK.

Publikováno v: Pharmaceutics [Pharmaceutics] 2022 Jun 16; Vol. 14 (6). Date of Electronic Publication: 2022 Jun 16.

Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019.

Autor: Harvala H; Microbiology Services, NHS Blood and Transplant, London, UK heli.harvalasimmonds@nhsbt.nhs.uk.; Infection and Immunity, University College London, London, UK., Reynolds C; NHS Blood and Transplant/Public Health England Epidemiology Unit, NHS Blood and Transplant, London, UK., Ijaz S; National Infection Service, Public Health England, London, UK., Maddox V; Microbiology Services, NHS Blood and Transplant, London, UK., Penchala SD; Department of Pharmacology, University of Liverpool, Liverpool, UK., Amara A; Department of Pharmacology, University of Liverpool, Liverpool, UK., Else L; Department of Pharmacology, University of Liverpool, Liverpool, UK., Brailsford S; Microbiology Services, NHS Blood and Transplant, London, UK.; NHS Blood and Transplant/Public Health England Epidemiology Unit, NHS Blood and Transplant, London, UK., Khoo S; Department of Pharmacology, University of Liverpool, Liverpool, UK.

Publikováno v: Sexually transmitted infections [Sex Transm Infect] 2022 Mar; Vol. 98 (2), pp. 132-135. Date of Electronic Publication: 2021 Mar 29.

The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva.

Autor: Amara A; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 7SX, UK. Electronic address: A.Amara@liverpool.ac.uk., Penchala SD; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 7SX, UK., Else L; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 7SX, UK., Hale C; The Royal Liverpool & Broadgreen University Hospitals NHS Trust, Prescot Road, Liverpool L7 8XP, UK., FitzGerald R; The Royal Liverpool & Broadgreen University Hospitals NHS Trust, Prescot Road, Liverpool L7 8XP, UK., Walker L; The Royal Liverpool & Broadgreen University Hospitals NHS Trust, Prescot Road, Liverpool L7 8XP, UK., Lyons R; The Royal Liverpool & Broadgreen University Hospitals NHS Trust, Prescot Road, Liverpool L7 8XP, UK., Fletcher T; Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK., Khoo S; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 7SX, UK; The Royal Liverpool & Broadgreen University Hospitals NHS Trust, Prescot Road, Liverpool L7 8XP, UK.

Publikováno v: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2021 Nov 30; Vol. 206, pp. 114356. Date of Electronic Publication: 2021 Sep 02.