Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase.

Autor: Meyer C; Laboratory for RNA Molecular Biology, The Rockefeller University, New York, NY, USA., Garzia A; Laboratory for RNA Molecular Biology, The Rockefeller University, New York, NY, USA., Miller MW; Sanders Tri-Institutional Therapeutics Discovery Institute, The Rockefeller University, New York, NY, USA., Huggins DJ; Sanders Tri-Institutional Therapeutics Discovery Institute, The Rockefeller University, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA., Myers RW; Sanders Tri-Institutional Therapeutics Discovery Institute, The Rockefeller University, New York, NY, USA., Hoffmann HH; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Ashbrook AW; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Jannath SY; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Liverton N; Sanders Tri-Institutional Therapeutics Discovery Institute, The Rockefeller University, New York, NY, USA., Kargman S; Sanders Tri-Institutional Therapeutics Discovery Institute, The Rockefeller University, New York, NY, USA., Zimmerman M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Nelson AM; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Sharma V; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Dolgov E; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Cangialosi J; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Penalva-Lopez S; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Alvarez N; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Chang CW; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.; Department of Medicine, Division of Infectious Diseases, Columbia University, New York, NY, USA., Oswal N; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Gonzalez I; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Rasheed R; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Goldgirsh K; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Davis JA; Laboratory for RNA Molecular Biology, The Rockefeller University, New York, NY, USA., Ramos-Espiritu L; Fisher Drug Discovery Resource Center, The Rockefeller University, New York, NY, USA., Menezes MR; Fisher Drug Discovery Resource Center, The Rockefeller University, New York, NY, USA., Larson C; Fisher Drug Discovery Resource Center, The Rockefeller University, New York, NY, USA., Nitsche J; PROTEROS Biostructures GmbH, Planegg-Martinsried, Germany., Ganichkin O; PROTEROS Biostructures GmbH, Planegg-Martinsried, Germany., Alwaseem H; Proteomics Resource Center, The Rockefeller University, New York, NY, USA., Molina H; Proteomics Resource Center, The Rockefeller University, New York, NY, USA., Steinbacher S; PROTEROS Biostructures GmbH, Planegg-Martinsried, Germany., Glickman JF; Fisher Drug Discovery Resource Center, The Rockefeller University, New York, NY, USA., Perlin DS; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Meinke PT; Sanders Tri-Institutional Therapeutics Discovery Institute, The Rockefeller University, New York, NY, USA., Tuschl T; Laboratory for RNA Molecular Biology, The Rockefeller University, New York, NY, USA. ttuschl@rockefeller.edu.

Publikováno v: Nature [Nature] 2024 Dec 11. Date of Electronic Publication: 2024 Dec 11.

Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis.

Autor: Hassoun, Yasmine¹ (AUTHOR), Aptekmann, Ariel A.¹ (AUTHOR), Keniya, Mikhail V.¹ (AUTHOR), Gomez, Rosa Y.¹ (AUTHOR), Alayo, Nicole¹ (AUTHOR), Novi, Giovanna¹ (AUTHOR), Quinteros, Christopher¹ (AUTHOR), Kaya, Firat¹ (AUTHOR), Zimmerman, Matthew¹ (AUTHOR), Caceres, Diego H.^2,3,4 (AUTHOR), Chow, Nancy A.² (AUTHOR), Perlin, David S.^1,5,6 (AUTHOR) david.perlin@hmh-cdi.org, Shor, Erika^1,5 (AUTHOR) erika.shor@hmh-cdi.org

Publikováno v: PLoS Pathogens. 9/9/2024, Vol. 20 Issue 9, p1-25. 25p.

Persistence and Culturability of Escherichia coli under Induced Toxin Expression.

Autor: Dhaouadi, Yousr, Hashemi, Mohamad Javad, Ren, Dacheng

Publikováno v: Antibiotics (2079-6382); Sep2024, Vol. 13 Issue 9, p863, 16p

β-Estradiol and progesterone enhance biofilm development and persister cell formation in monospecies and microcosms biofilms derived from vulvovaginal candidiasis.

Autor: Andrade, Ana Raquel Colares de, Rezende, Mônica Dantas Sampaio, Portela, Fernando Victor Monteiro, Pereira, Livia Maria Galdino, Nascimento da Silva, Bruno, Lima-Neto, Reginaldo Gonçalves de, Rocha, Marcos Fábio Gadelha, Sidrim, José Júlio Costa, Castelo-Branco, Débora Souza Collares Maia, Cordeiro, Rossana de Aguiar

Publikováno v: Biofouling; Aug/Sep2023, Vol. 39 Issue 7, p719-729, 11p

Advances in Antifungal Drug Development : Natural Products with Antifungal Potential

Autor: Nikhat Manzoor

This book explores the antifungal properties of natural products and reviews their antifungal mechanism. An introductory chapter illustrates the various fungal pathogenic species, common fungal diseases, and general mechanisms of action of various an