The impact of lenvatinib on sarcopenia in patients with advanced unresectable hepatocellular carcinoma

Autor: Michael Praktiknjo, Ana S. Pena Solano, Farsaneh Sadeghlar, Thomas Welchowski, Matthias Schmid, Christian Möhring, Taotao Zhou, Robert Mahn, Malte B. Monin, Carsten Meyer, Georg Feldmann, Peter Brossart, Cornelius van Beekum, Alexander Semaan, Hanno Matthaei, Steffen Manekeller, Alois M. Sprinkart, Sebastian Nowak, Julian Luetkens, Jörg C. Kalff, Christian P. Strassburg, Maria A. González-Carmona

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Lenvatinib is a multiple receptor tyrosine kinase inhibitor (TKI) approved for first-line treatment of patients with unresectable hepatocellular carcinoma (HCC). TKI are suspected of exacerbating muscle loss in patients with cancer. In this

Externí odkaz: https://doaj.org/article/e8b3f61e90fe4943b829122cfda08c0d

The impact of lenvatinib on sarcopenia in patients with advanced unresectable hepatocellular carcinoma.

Autor: Praktiknjo M; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.; Department of Internal Medicine B, University Hospital Münster, Münster, Germany., Pena Solano AS; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Sadeghlar F; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Welchowski T; Department of Medical Biometry, Informatics and Epidemiology (IMBIE), University Hospital Bonn, Bonn, Germany., Schmid M; Department of Medical Biometry, Informatics and Epidemiology (IMBIE), University Hospital Bonn, Bonn, Germany., Möhring C; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Zhou T; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Mahn R; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Monin MB; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Meyer C; Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany., Feldmann G; Department of Internal Medicine III, University Hospital Bonn, Bonn, Germany., Brossart P; Department of Internal Medicine III, University Hospital Bonn, Bonn, Germany., van Beekum C; Department of Visceral Surgery, University Hospital Bonn, Bonn, Germany.; Department of General- Abdominal and Transplant Surgery, Hanover Medical School, Hannover, Germany., Semaan A; Department of Visceral Surgery, University Hospital Bonn, Bonn, Germany., Matthaei H; Department of Visceral Surgery, University Hospital Bonn, Bonn, Germany., Manekeller S; Department of Visceral Surgery, University Hospital Bonn, Bonn, Germany., Sprinkart AM; Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany., Nowak S; Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany., Luetkens J; Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany., Kalff JC; Department of Visceral Surgery, University Hospital Bonn, Bonn, Germany., Strassburg CP; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., González-Carmona MA; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany. maria.gonzalez-carmona@ukbonn.de.

Publikováno v: Scientific reports [Sci Rep] 2024 Sep 27; Vol. 14 (1), pp. 22146. Date of Electronic Publication: 2024 Sep 27.