Improved Diffusion Interaction Parameter Measurement to Predict the Viscosity of Concentrated mAb Solutions.

Autor: Wei Y; Drug Product Technologies, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, California 91320, United States., Qi W; Drug Product Technologies, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, California 91320, United States., Maglalang E; Drug Product Technologies, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, California 91320, United States., Pelegri-O'Day EM; Molecular Analytics, Biologics Therapeutics Discovery, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, California 91320, United States., Luong M; Drug Product Technologies, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, California 91320, United States., Razinkov V; Drug Product Technologies, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, California 91320, United States., Sloey C; Drug Product Technologies, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, California 91320, United States.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2023 Dec 04; Vol. 20 (12), pp. 6420-6428. Date of Electronic Publication: 2023 Oct 31.

Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies.

Autor: Mock M; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Jacobitz AW; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Langmead CJ; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Sudom A; Structural Biology, Amgen Research, South San Francisco, CA, USA., Yoo D; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Humphreys SC; Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, CA, USA., Alday M; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Alekseychyk L; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Angell N; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Bi V; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Catterall H; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Chen CC; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Chou HT; Structural Biology, Amgen Research, South San Francisco, CA, USA., Conner KP; Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, CA, USA., Cook KD; Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, CA, USA., Correia AR; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Dykstra A; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Ghimire-Rijal S; Structural Biology, Amgen Research, Thousand Oaks, CA, USA., Graham K; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Grandsard P; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Huh J; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Hui JO; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Jain M; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Jann V; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Jia L; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Johnstone S; Structural Biology, Amgen Research, South San Francisco, CA, USA., Khanal N; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Kolvenbach C; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Narhi L; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Padaki R; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Pelegri-O'Day EM; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Qi W; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Razinkov V; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Rice AJ; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Smith R; Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, CA, USA., Spahr C; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Stevens J; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Sun Y; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Thomas VA; Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, CA, USA., van Driesche S; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Vernon R; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Wagner V; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Walker KW; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Wei Y; Process Development, Amgen Operations, Thousand Oaks, CA, USA., Winters D; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Yang M; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA., Campuzano IDG; Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA.

Publikováno v: MAbs [MAbs] 2023 Jan-Dec; Vol. 15 (1), pp. 2256745.

Synthesis of Zwitterionic and Trehalose Polymers with Variable Degradation Rates and Stabilization of Insulin.

Autor: Pelegri-O'Day EM; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Bhattacharya A; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Theopold N; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Ko JH; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Maynard HD; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.

Publikováno v: Biomacromolecules [Biomacromolecules] 2020 Jun 08; Vol. 21 (6), pp. 2147-2154. Date of Electronic Publication: 2020 May 05.

Synthesis and Biological Evaluation of a Degradable Trehalose Glycopolymer Prepared by RAFT Polymerization.

Autor: Lau UY; Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA., Pelegri-O'Day EM; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA, 90095, USA., Maynard HD; Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA.; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA, 90095, USA.

Publikováno v: Macromolecular rapid communications [Macromol Rapid Commun] 2018 Mar; Vol. 39 (5). Date of Electronic Publication: 2017 Dec 18.

Controlled Radical Polymerization as an Enabling Approach for the Next Generation of Protein-Polymer Conjugates.

Autor: Pelegri-O'Day EM; Department of Chemistry and Biochemistry and California Nanosystems Institute, University of California, Los Angeles , 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Maynard HD; Department of Chemistry and Biochemistry and California Nanosystems Institute, University of California, Los Angeles , 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.

Publikováno v: Accounts of chemical research [Acc Chem Res] 2016 Sep 20; Vol. 49 (9), pp. 1777-85. Date of Electronic Publication: 2016 Sep 02.