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Akademický článek

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

Autor: Schnute ME, Wennerstål M; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Alley J, Bengtsson M; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Blinn JR, Bolten CW, Braden T, Bonn T; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Carlsson B; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Caspers N; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Chen M; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Choi C; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Collis LP, Crouse K, Färnegårdh M; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Fennell KF; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Fish S, Flick AC; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Goos-Nilsson A; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Gullberg H; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Harris PK, Heasley SE; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Hegen M, Hromockyj AE, Hu X, Husman B; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Janosik T; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Jones P, Kaila N, Kallin E; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Kauppi B; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Kiefer JR, Knafels J; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Koehler K; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Kruger L; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Kurumbail RG; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Kyne RE Jr; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Li W, Löfstedt J; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Long SA, Menard CA; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Mente S, Messing D, Meyers MJ, Napierata L, Nöteberg D; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Nuhant P; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Pelc MJ, Prinsen MJ, Rhönnstad P; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Backström-Rydin E; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Sandberg J; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Sandström M; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Shah F, Sjöberg M; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Sundell A; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Taylor AP; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Thorarensen A, Trujillo JI; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Trzupek JD, Unwalla R, Vajdos FF; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States., Weinberg RA, Wood DC, Xing L, Zamaratski E; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Zapf CW, Zhao Y, Wilhelmsson A; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden., Berstein G

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Dec 13; Vol. 61 (23), pp. 10415-10439. Date of Electronic Publication: 2018 Sep 09.

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Akademický článek

Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds.

Autor: Meyers MJ; Pfizer Global Research & Development, St. Louis Laboratories, 700 Chesterfield Parkway West, Chesterfield, MO 63017, United States. mmeyers8@slu.edu, Long SA, Pelc MJ, Wang JL, Bowen SJ, Walker MC, Schweitzer BA, Madsen HM, Tenbrink RE, McDonald J, Smith SE, Foltin S, Beidler D, Thorarensen A

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Nov 01; Vol. 21 (21), pp. 6538-44. Date of Electronic Publication: 2011 Aug 22.

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Akademický článek

Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain.

Autor: Meyers MJ; Pfizer Global Research & Development, St. Louis Laboratories, 700 Chesterfield Parkway West, Chesterfield, MO 63017, United States. mmeyers8@slu.edu, Long SA, Pelc MJ, Wang JL, Bowen SJ, Schweitzer BA, Wilcox MV, McDonald J, Smith SE, Foltin S, Rumsey J, Yang YS, Walker MC, Kamtekar S, Beidler D, Thorarensen A

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Nov 01; Vol. 21 (21), pp. 6545-53. Date of Electronic Publication: 2011 Aug 19.

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Akademický článek

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS).

Autor: Carron CP; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Trujillo JI; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Olson KL; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Huang W; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Hamper BC; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Dice T; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Neal BE; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Pelc MJ; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Day JE; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Rohrer DC; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Kiefer JR; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Moon JB; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Schweitzer BA; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Blake TD; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Turner SR; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Woerndle R; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Case BL; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Bono CP; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Dilworth VM; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Funckes-Shippy CL; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Hood BL; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Jerome GM; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Kornmeier CM; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Radabaugh MR; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Williams ML; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Davies MS; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Wegner CD; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Welsch DJ; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Abraham WM; Department of Research, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, Florida 33140., Warren CJ; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Dowty ME; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Hua F; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Zutshi A; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Yang JZ; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017., Thorarensen A; Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2010 Feb 02; Vol. 1 (2), pp. 59-63. Date of Electronic Publication: 2010 Feb 02 (Print Publication: 2010).

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Akademický článek

Structure based design of novel irreversible FAAH inhibitors.

Autor: Wang JL; Pfizer Global Research and Development, 700 Chesterfield PKWY West, Chesterfield, MO 63017, USA. jane.l.wang@pfizer.com, Bowen SJ, Schweitzer BA, Madsen HM, McDonald J, Pelc MJ, Tenbrink RE, Beidler D, Thorarensen A

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Oct 15; Vol. 19 (20), pp. 5970-4. Date of Electronic Publication: 2009 Jul 25.

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