Výsledky vyhledávání - "Pelagia Kyriakidou"

Spectrum graph-based de-novo sequencing algorithm MaxNovo achieves high peptide identification rates in collisional dissociation MS/MS spectra

Autor: Petra Gutenbrunner, Pelagia Kyriakidou, Jürgen Cox, Frido Welker

Publikováno v: bioRxiv

We describe MaxNovo, a novel spectrum graph-based peptide de-novo sequencing algorithm integrated into the MaxQuant software. It identifies complete sequences of peptides as well as sequence tags that are incomplete at one or both of the peptide term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95be0c5cbd83576939ebb42b7f8810c

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Isobaric matching between runs and novel PSM-level normalization in MaxQuant strongly improve reporter ion-based quantification

Autor: Pelagia Kyriakidou, Jürgen Cox, Sung-Huan Yu

Publikováno v: Journal of Proteome Research

Isobaric labeling has the promise of combining high sample multiplexing with precise quantification. However, normalization issues and the missing value problem of complete n-plexes hamper quantification across more than one n-plex. Here, we introduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7c924ac39dd396355b74ffd401ef9f
https://doi.org/10.1101/2020.03.30.015487

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Mass Cytometry for Multivariate Organoid Signalling Analysis

Autor: Pelagia Kyriakidou, Xiao Qin, Sophie E. Acton, Mark Nitz, Petra Vlckova, Vivian S. W. Li, Christopher J. Tape, Jahangir Sufi

Organoids are powerful biomimetic tissue models. Despite their increasing popularity, no existing methods are suitable for cell-type specific analysis of post-translational modification (PTM) signalling networks in organoids. Here we report a multiva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c32517f023beeecf278cb8d924d2356
https://doi.org/10.21203/rs.2.16232/v2

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Cell-type-specific signaling networks in heterocellular organoids

Autor: Vivian S. W. Li, Sophie E. Acton, Xiao Qin, Mark Nitz, Jahangir Sufi, Christopher J. Tape, Petra Vlckova, Pelagia Kyriakidou

Publikováno v: Nature methods

Organoids are powerful biomimetic tissue models. Despite their widespread adoption, methods to analyse cell-type specific post-translational modification (PTM) signalling networks in organoids are absent. Here we report multivariate single-cell analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f64790a56a87a6bad62ed53f06d8f59
https://pubmed.ncbi.nlm.nih.gov/32066960

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Single-Cell Signalling Analysis of Heterocellular Organoids

Autor: Vivian S. W. Li, Xiao Qin, Jahangir Sufi, Pelagia Kyriakidou, Mark Nitz, Petra Vlckova, Sophie E. Acton, Christopher J. Tape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644e41dd47dbc65895ba5852f18908a0

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Estimating the total number of phosphoproteins and phosphorylation sites in eukaryotic proteomes

Autor: Stephen G. Oliver, Pelagia Kyriakidou, Panayotis Vlastaridis, Grigoris D. Amoutzias, Yves Van de Peer, Anargyros Chaliotis

Publikováno v: GIGASCIENCE
GigaScience

Background Phosphorylation is the most frequent post-translational modification made to proteins and may regulate protein activity as either a molecular digital switch or a rheostat. Despite the cornucopia of high-throughput (HTP) phosphoproteomic da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe3ec1176635cdcd191caaa5bd9dd2a
https://doi.org/10.1093/gigascience/giw015

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