Supplementary Figures 1-8 from Hypoxic Conversion of SMAD7 Function from an Inhibitor into a Promoter of Cell Invasion

Autor: Panu M. Jaakkola, Veli-Matti Kähäri, Reidar Grenman, Terhi Jokilehto, Marika Nummela, Pekka T. Heikkinen

Supplementary Figures 1-8 from Hypoxic Conversion of SMAD7 Function from an Inhibitor into a Promoter of Cell Invasion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1333cebdde82da9cc99875636badf0
https://doi.org/10.1158/0008-5472.22382622

Data from Hypoxic Conversion of SMAD7 Function from an Inhibitor into a Promoter of Cell Invasion

Autor: Panu M. Jaakkola, Veli-Matti Kähäri, Reidar Grenman, Terhi Jokilehto, Marika Nummela, Pekka T. Heikkinen

Smad7 is an inhibitor of the transforming growth factor-β–activated signaling pathway. Under well-oxygenated conditions, Smad7 is a potent inhibitor of carcinoma cell invasion. Paradoxically, however, the expression of Smad7 is upregulated across

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a352aaaf90d13cc9d502c441b83cda5
https://doi.org/10.1158/0008-5472.c.6500265

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay

Autor: Richard A. Spellman, David Kirkland, Véronique Thybaud, Melanie Guérard, Stephen D. Dertinger, Steven M. Bryce, Andreas Zeller, Jeffrey C. Bemis, Maik Schuler, Sabrina Wilde, Elisabeth Lorge, Andreas Sutter, Ulrike Hemmann, Nina Queisser, Pekka T. Heikkinen, Derek T. Bernacki, Maria Engel

Publikováno v: Environmental and Molecular Mutagenesis. 58:146-161

We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric analysis of detergent-liberated nuclei that are simultaneously stained with propidium iodide and labeled with fluorescent antibodies against p53, γH2AX, and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fada4cc49d4b86be27dafc87bb3b2f93
https://doi.org/10.1002/em.22083

Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1α Signaling

Autor: Frank E. Jones, Panu Jaakkola, Ilkka Paatero, Olli-Pekka Kallioniemi, Klaus Elenius, Kristiina Iljin, Pekka T. Heikkinen, Anne Jokilammi

Publikováno v: Paatero, I, Jokilammi, A, Heikkinen, P T, Iljin, K, Kallioniemi, O, Jones, F J, Jaakkola, P M & Elenius, K 2012, ' Interaction with ErbB4 promotes hypoxia-inducible factor-1α signaling ', Journal of Biological Chemistry, vol. 287, no. 13, pp. 9659-9671 . https://doi.org/10.1074/jbc.M111.299537

The receptor-tyrosine kinase ErbB4 was identified as a direct regulator of hypoxia-inducible factor-1α (HIF-1α) signaling. Cleaved intracellular domain of ErbB4 directly interacted with HIF-1α in the nucleus, and stabilized HIF-1α protein in both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09267199d37e101271767d20e1e05d4e
https://doi.org/10.1074/jbc.m111.299537

Hypoxia-activated Smad3-specific Dephosphorylation by PP2A

Autor: Pekka T. Heikkinen, Panu Jaakkola, Caroline S. Hill, Marika Nummela, Jukka Westermarck, Suvi-Katri Leivonen, Veli-Matti Kähäri

Publikováno v: Journal of Biological Chemistry. 285:3740-3749

The transforming growth factor-beta (TGF-beta) maintains epithelial homeostasis and suppresses early tumor formation, but paradoxically at later stages of tumor progression, TGF-beta promotes malignancy. TGF-beta activates phosphorylation of Smad2 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb9d16219db9bc06920b927e2cc65ed
https://doi.org/10.1074/jbc.m109.042978