Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Pekka Ruusuvuori"'
Autor:
Oona Paavolainen, Markus Peurla, Leena M. Koskinen, Jonna Pohjankukka, Kamyab Saberi, Ella Tammelin, Suvi-Riitta Sulander, Masi Valkonen, Larissa Mourao, Pia Boström, Nina Brück, Pekka Ruusuvuori, Colinda L.G.J. Scheele, Pauliina Hartiala, Emilia Peuhu
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114837- (2024)
Summary: The major lactiferous ducts of the human breast branch out and end at terminal ductal lobular units (TDLUs). Despite their functional and clinical importance, the three-dimensional (3D) architecture of TDLUs has remained undetermined. Our qu
Externí odkaz:
https://doaj.org/article/4fcb5c262ff1458f9cfbb71c980860cf
Autor:
Fabi Prezja, Leevi Annala, Sampsa Kiiskinen, Suvi Lahtinen, Timo Ojala, Pekka Ruusuvuori, Teijo Kuopio
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37561- (2024)
In routine colorectal cancer management, histologic samples stained with hematoxylin and eosin are commonly used. Nonetheless, their potential for defining objective biomarkers for patient stratification and treatment selection is still being explore
Externí odkaz:
https://doaj.org/article/d95a63be1ea04dc7a4ea262eeaea2c9d
Autor:
Enkhzaya Batnasan, Minttu Kärkkäinen, Sonja Koivukoski, Nithin Sadeesh, Sylvain Tollis, Pekka Ruusuvuori, Mauro Scaravilli, Leena Latonen
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Purpose Platinum-based drugs are cytotoxic drugs commonly used in cancer treatment. They cause DNA damage, effects of which on chromatin and cellular responses are relatively well described. Yet, the nuclear stress responses related to RNA p
Externí odkaz:
https://doaj.org/article/4b429888cb0e4d949946d916ecdab38d
Autor:
Kirsi J. Rautajoki, Serafiina Jaatinen, Anja Hartewig, Aliisa M. Tiihonen, Matti Annala, Iida Salonen, Masi Valkonen, Vili Simola, Elisa M. Vuorinen, Anni Kivinen, Minna J. Rauhala, Riikka Nurminen, Kendra K. Maass, Sirpa-Liisa Lahtela, Arja Jukkola, Olli Yli-Harja, Pauli Helén, Kristian W. Pajtler, Pekka Ruusuvuori, Joonas Haapasalo, Wei Zhang, Hannu Haapasalo, Matti Nykter
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract As the progression of low-grade diffuse astrocytomas into grade 4 tumors significantly impacts patient prognosis, a better understanding of this process is of paramount importance for improved patient care. In this project, we analyzed match
Externí odkaz:
https://doaj.org/article/93bb5201f4a448cca5fb328e55e9e60a
Autor:
Fabi Prezja, Sami Äyrämö, Ilkka Pölönen, Timo Ojala, Suvi Lahtinen, Pekka Ruusuvuori, Teijo Kuopio
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Hematoxylin and eosin-stained biopsy slides are regularly available for colorectal cancer patients. These slides are often not used to define objective biomarkers for patient stratification and treatment selection. Standard biomarkers often
Externí odkaz:
https://doaj.org/article/b9c09d0da1fc45be8e6e28e91ba6522f
Autor:
Philippe Weitz, Masi Valkonen, Leslie Solorzano, Circe Carr, Kimmo Kartasalo, Constance Boissin, Sonja Koivukoski, Aino Kuusela, Dusan Rasic, Yanbo Feng, Sandra Sinius Pouplier, Abhinav Sharma, Kajsa Ledesma Eriksson, Leena Latonen, Anne-Vibeke Laenkholm, Johan Hartman, Pekka Ruusuvuori, Mattias Rantalainen
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-6 (2023)
Abstract The analysis of FFPE tissue sections stained with haematoxylin and eosin (H&E) or immunohistochemistry (IHC) is essential for the pathologic assessment of surgically resected breast cancer specimens. IHC staining has been broadly adopted int
Externí odkaz:
https://doaj.org/article/8c1c1f1b270a4714814e409886e0d825
Autor:
Henrik Olsson, Kimmo Kartasalo, Nita Mulliqi, Marco Capuccini, Pekka Ruusuvuori, Hemamali Samaratunga, Brett Delahunt, Cecilia Lindskog, Emiel A. M. Janssen, Anders Blilie, ISUP Prostate Imagebase Expert Panel, Lars Egevad, Ola Spjuth, Martin Eklund
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Artificial intelligence prediction accuracy can be reduced with new data. Here, the authors utilise conformal prediction to reduce incorrect predictions in histopathological analysis of prostate cancer biopsies.
Externí odkaz:
https://doaj.org/article/c697f101952b488aa809d38a2d2d86b0
Autor:
Mauro Scaravilli, Sonja Koivukoski, Andrew Gillen, Aya Bouazza, Pekka Ruusuvuori, Tapio Visakorpi, Leena Latonen
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-10 (2022)
Abstract miR-32 is an androgen receptor (AR)-regulated microRNA, expression of which is increased in castration-resistant prostate cancer (PC). We have previously shown that overexpression of miR-32 in the prostate of transgenic mice potentiates prol
Externí odkaz:
https://doaj.org/article/8b00cb9c06af4b8384ece098cd130091
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0286270 (2023)
Tumor-stroma ratio (TSR) is a prognostic factor for many types of solid tumors. In this study, we propose a method for automated estimation of TSR from histopathological images of colorectal cancer. The method is based on convolutional neural network
Externí odkaz:
https://doaj.org/article/4c9cc0ff0ed34a3488b09052ca6108f7
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021)
Abstract Background Virtual reality (VR) enables data visualization in an immersive and engaging manner, and it can be used for creating ways to explore scientific data. Here, we use VR for visualization of 3D histology data, creating a novel interfa
Externí odkaz:
https://doaj.org/article/094eee0a36b944c9a09176943c7c2963