Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Pekka Pölönen"'
Publikováno v:
Informatics in Medicine Unlocked, Vol 46, Iss , Pp 101480- (2024)
Machine learning that is the vital part of modern artificial intelligence was used to classify the potential effects of two drugs on induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM). Peak data were detected from calcium transient signal
Externí odkaz:
https://doaj.org/article/43f3f529259e4ac9bd7e90582269055a
Publikováno v:
Computing in Cardiology Conference (CinC).
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer a unique in vitro platform to study cardiac diseases, as they recapitulate many disease phenotypes. The membrane potential (Vm) and intracellular calcium (Ca2+) transient (C
Externí odkaz:
https://doaj.org/article/5a1f9ae04e564dbb94b4133b7e9faa78
Autor:
Michelangelo Paci, Risto-Pekka Pölönen, Dario Cori, Kirsi Penttinen, Katriina Aalto-Setälä, Stefano Severi, Jari Hyttinen
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The growing importance of human induced pluripotent stem cell-derived cardiomyoyctes (hiPSC-CMs), as patient-specific and disease-specific models for studying cellular cardiac electrophysiology or for preliminary cardiotoxicity tests, generated bette
Externí odkaz:
https://doaj.org/article/a2dc1ac1ff81486799c84a6c6005424a
Autor:
Mari Pekkanen-Mattila, Martta Häkli, Risto-Pekka Pölönen, Tuomas Mansikkala, Anni Junnila, Elina Talvitie, Janne T Koivisto, Minna Kellomäki, Katriina Aalto-Setälä
Publikováno v:
Materials, Vol 12, Iss 11, p 1805 (2019)
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to serve as a model for human cardiomyocytes. However, hiPSC-CMs are still considered immature. CMs differentiated from hiPSCs more resemble fetal than adult ca
Externí odkaz:
https://doaj.org/article/7fe2d5639649499cb0323616fa7a097e
Autor:
Marisa Ojala, Chandra Prajapati, Risto-Pekka Pölönen, Kristiina Rajala, Mari Pekkanen-Mattila, Jyrki Rasku, Kim Larsson, Katriina Aalto-Setälä
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease, which affects the structure of heart muscle tissue. The clinical symptoms include arrhythmias, progressive heart failure, and even sudden cardiac death but the mutation carrier can also
Externí odkaz:
https://doaj.org/article/8bd67d192056495f9485d4f44a3ffb3c
Autor:
Donald M. Bers, Kenneth S. Ginsburg, Mark Mercola, Risto Pekka Pölönen, Julie Bossuyt, Kim T. Hellgren, Christopher Y. Ko, Bence Hegyi
Publikováno v:
Basic Research in Cardiology. 116
Cardiomyocyte Na+ and Ca2+ mishandling, upregulated Ca2+/calmodulin-dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are characteristics of various heart diseases, including heart failure (HF), long QT (LQT) syndrome, and cat
Autor:
Bence, Hegyi, Risto-Pekka, Pölönen, Kim T, Hellgren, Christopher Y, Ko, Kenneth S, Ginsburg, Julie, Bossuyt, Mark, Mercola, Donald M, Bers
Publikováno v:
Basic Research in Cardiology
Cardiomyocyte Na+ and Ca2+ mishandling, upregulated Ca2+/calmodulin-dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are characteristics of various heart diseases, including heart failure (HF), long QT (LQT) syndrome, and cat
Autor:
Martti Juhola, Henry Joutsijoki, Kirsi Penttinen, Disheet Shah, Risto-Pekka Pölönen, Katriina Aalto-Setälä
Publikováno v:
Computers in Biology and Medicine. 142:105218
In the present research we tackled the classification of seven genetic cardiac diseases and control subjects by using an extensive set of machine learning algorithms with their variations from simple K-nearest neighbor searching method to support vec
Autor:
Kenneth S. Ginsburg, Charlotta Sophie Behrens, Renee G.C. Maas, Michaela Schweizer, Larissa Hörmann, Bence Hegyi, Joseph C. Wu, Wesley L. McKeithan, Risto Pekka Pölönen, Christine Wahlquist, Christian M. Metallo, Francesca Briganti, Matthew Greenhaw, Zhandi Liao, Ricardo Serrano, Arne A. N. Bruyneel, Mark Mercola, Dries A. M. Feyen, Chi Keung Lam, Daniel Bernstein, Hui Zhang, Alexander Kreymerman, Michelle Vu, Sean Spiering, Donald M. Bers, Prashila L Amatya, Thomas Eschenhagen, Bärbel M. Ulmer, Sara Ranjbarvaziri
Publikováno v:
Cell reports
Cell reports, vol 32, iss 3
Cell reports, vol 32, iss 3
SUMMARY Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential for the study of human cardiac disorders. However, their physiological immaturity severely limits their utility as a model system and their adoption for d