Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Pekka Pölönen"'
Publikováno v:
Informatics in Medicine Unlocked, Vol 46, Iss , Pp 101480- (2024)
Machine learning that is the vital part of modern artificial intelligence was used to classify the potential effects of two drugs on induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM). Peak data were detected from calcium transient signal
Externí odkaz:
https://doaj.org/article/43f3f529259e4ac9bd7e90582269055a
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer a unique in vitro platform to study cardiac diseases, as they recapitulate many disease phenotypes. The membrane potential (Vm) and intracellular calcium (Ca2+) transient (C
Externí odkaz:
https://doaj.org/article/5a1f9ae04e564dbb94b4133b7e9faa78
Autor:
Michelangelo Paci, Risto-Pekka Pölönen, Dario Cori, Kirsi Penttinen, Katriina Aalto-Setälä, Stefano Severi, Jari Hyttinen
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The growing importance of human induced pluripotent stem cell-derived cardiomyoyctes (hiPSC-CMs), as patient-specific and disease-specific models for studying cellular cardiac electrophysiology or for preliminary cardiotoxicity tests, generated bette
Externí odkaz:
https://doaj.org/article/a2dc1ac1ff81486799c84a6c6005424a
Publikováno v:
Computing in Cardiology Conference (CinC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00bd4840fc03fe6f24630c73cf8f2b8a
https://doi.org/10.22489/cinc.2022.167
https://doi.org/10.22489/cinc.2022.167
Autor:
Marisa Ojala, Chandra Prajapati, Risto-Pekka Pölönen, Kristiina Rajala, Mari Pekkanen-Mattila, Jyrki Rasku, Kim Larsson, Katriina Aalto-Setälä
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease, which affects the structure of heart muscle tissue. The clinical symptoms include arrhythmias, progressive heart failure, and even sudden cardiac death but the mutation carrier can also
Externí odkaz:
https://doaj.org/article/8bd67d192056495f9485d4f44a3ffb3c
Autor:
Donald M. Bers, Kenneth S. Ginsburg, Mark Mercola, Risto Pekka Pölönen, Julie Bossuyt, Kim T. Hellgren, Christopher Y. Ko, Bence Hegyi
Publikováno v:
Basic Research in Cardiology. 116
Cardiomyocyte Na+ and Ca2+ mishandling, upregulated Ca2+/calmodulin-dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are characteristics of various heart diseases, including heart failure (HF), long QT (LQT) syndrome, and cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9bd7975e9fb8820f4352788d5d3107b
https://doi.org/10.1007/s00395-021-00900-9
https://doi.org/10.1007/s00395-021-00900-9
Autor:
Bence, Hegyi, Risto-Pekka, Pölönen, Kim T, Hellgren, Christopher Y, Ko, Kenneth S, Ginsburg, Julie, Bossuyt, Mark, Mercola, Donald M, Bers
Publikováno v:
Basic Research in Cardiology
Cardiomyocyte Na+ and Ca2+ mishandling, upregulated Ca2+/calmodulin-dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are characteristics of various heart diseases, including heart failure (HF), long QT (LQT) syndrome, and cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a796f8907530a0d9fd251d37178b0b1a
https://pubmed.ncbi.nlm.nih.gov/34648073
https://pubmed.ncbi.nlm.nih.gov/34648073
Autor:
Kenneth S. Ginsburg, Charlotta Sophie Behrens, Renee G.C. Maas, Michaela Schweizer, Larissa Hörmann, Bence Hegyi, Joseph C. Wu, Wesley L. McKeithan, Risto Pekka Pölönen, Christine Wahlquist, Christian M. Metallo, Francesca Briganti, Matthew Greenhaw, Zhandi Liao, Ricardo Serrano, Arne A. N. Bruyneel, Mark Mercola, Dries A. M. Feyen, Chi Keung Lam, Daniel Bernstein, Hui Zhang, Alexander Kreymerman, Michelle Vu, Sean Spiering, Donald M. Bers, Prashila L Amatya, Thomas Eschenhagen, Bärbel M. Ulmer, Sara Ranjbarvaziri
Publikováno v:
Cell reports
Cell reports, vol 32, iss 3
Cell reports, vol 32, iss 3
SUMMARY Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential for the study of human cardiac disorders. However, their physiological immaturity severely limits their utility as a model system and their adoption for d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23942c1aa9af3e3932c03e8e88fdc9e1
https://pubmed.ncbi.nlm.nih.gov/32697997
https://pubmed.ncbi.nlm.nih.gov/32697997
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited cardiac disease characterized by arrhythmias under adrenergic stress. Mutations in the cardiac ryanodine receptor (RYR2) are the leading cause for CPVT. We characterized ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c0ad89c7f77c9271bb7afcb7457961
http://hdl.handle.net/10138/325283
http://hdl.handle.net/10138/325283
Autor:
Marisa Ojala, Feihu Zhao, Katriina Aalto-Setälä, Pasi Kallio, Marlitt Viehrig, Joose Kreutzer, Risto Pekka Pölönen
Publikováno v:
Kreutzer, J, Viehrig, M, Pölönen, R P, Zhao, F, Ojala, M, Aalto-Setälä, K & Kallio, P 2020, ' Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes ', Biomechanics and Modeling in Mechanobiology, vol. 19, pp. 291–303 . https://doi.org/10.1007/s10237-019-01211-8
Biomechanics and Modeling in Mechanobiology
Biomechanics and Modeling in Mechanobiology, 19(1), 291-303. Springer
Biomechanics and Modeling in Mechanobiology
Biomechanics and Modeling in Mechanobiology, 19(1), 291-303. Springer
In this paper, we present a transparent mechanical stimulation device capable of uniaxial stimulation, which is compatible with standard bioanalytical methods used in cellular mechanobiology. We validate the functionality of the uniaxial stimulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01edaabbb933647fa78f0661aeafd29
https://orbit.dtu.dk/en/publications/9f2451e7-1aa4-454d-a6a3-116107405d91
https://orbit.dtu.dk/en/publications/9f2451e7-1aa4-454d-a6a3-116107405d91