Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Pekka Keski-Rahkonen"'
Publikováno v:
eLife, Vol 12 (2024)
Untargeted metabolomic profiling through liquid chromatography-mass spectrometry (LC-MS) measures a vast array of metabolites within biospecimens, advancing drug development, disease diagnosis, and risk prediction. However, the low throughput of LC-M
Externí odkaz:
https://doaj.org/article/30115f1a58ce442db8f042d039efe2b2
Autor:
Hwayoung Noh, Amélie Anota, Rodolf Mongondry, Renaud Meyrand, Carmen Dupuis, Camille Schiffler, Philippe Marijnen, Sabina Rinaldi, Joel Lachuer, Pekka Keski-Rahkonen, Marc J Gunter, Aude Fléchon, Béatrice Fervers, Olivia Pérol
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–40 years, with increasing incidence worldwide. About 33 ~ 50% of the patients present with metastatic disease at diagnosis. TGCT survivors experi
Externí odkaz:
https://doaj.org/article/fa667221073545d7a7c16b4f0698925a
Autor:
Rhea Harewood, Joseph A. Rothwell, Jelena Bešević, Vivian Viallon, David Achaintre, Audrey Gicquiau, Sabina Rinaldi, Roland Wedekind, Cornelia Prehn, Jerzy Adamski, Julie A. Schmidt, Inarie Jacobs, Anne Tjønneland, Anja Olsen, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Marcela Prada, Giovanna Masala, Claudia Agnoli, Salvatore Panico, Carlotta Sacerdote, Paula Gabriela Jakszyn, Maria-Jose Sánchez, Jesús Castilla, María-Dolores Chirlaque, Amaia Aizpurua Atxega, Bethany van Guelpen, Alicia K. Heath, Keren Papier, Tammy Y.N. Tong, Scott A. Summers, Mary Playdon, Amanda J. Cross, Pekka Keski-Rahkonen, Véronique Chajès, Neil Murphy, Marc J. Gunter
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 105024- (2024)
Summary: Background: Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods: In a case–control study nested within the European Prospectiv
Externí odkaz:
https://doaj.org/article/db0b1c75776340c68fff5c55e1fdf881
Autor:
Justin Harbs, Sabina Rinaldi, Pekka Keski-Rahkonen, Xijia Liu, Richard Palmqvist, Bethany Van Guelpen, Sophia Harlid
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Endogenous sex hormones and DNA methylation both play important roles in various diseases. However, their interplay is largely unknown. A deeper understanding of their interrelationships could provide new insights into the pathology of disease develo
Externí odkaz:
https://doaj.org/article/e3745d81a51b4911a7654a1af7793675
Autor:
Rossella Alfano, Daniela Zugna, Henrique Barros, Mariona Bustamante, Leda Chatzi, Akram Ghantous, Zdenko Herceg, Pekka Keski-Rahkonen, Theo M. de Kok, Tim S Nawrot, Caroline L Relton, Oliver Robinson, Theano Roumeliotaki, Augustin Scalbert, Martine Vrijheid, Paolo Vineis, Lorenzo Richiardi, Michelle Plusquin
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Background Rapid postnatal growth may result from exposure in utero or early life to adverse conditions and has been associated with diseases later in life and, in particular, with childhood obesity. DNA methylation, interfacing early-life e
Externí odkaz:
https://doaj.org/article/b375e003676f40249a2bc749b737791f
Autor:
Federica Bellerba, Anastasia Chrysovalantou Chatziioannou, Paniz Jasbi, Nivonirina Robinot, Pekka Keski-Rahkonen, Amarine Trolat, Béatrice Vozar, Sheri J. Hartman, Augustin Scalbert, Bernardo Bonanni, Harriet Johansson, Dorothy D. Sears, Sara Gandini
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Obesity is a major health concern for breast cancer survivors, being associated with high recurrence and reduced efficacy during cancer treatment. Metformin treatment is associated with reduced breast cancer incidence, recurrence
Externí odkaz:
https://doaj.org/article/981a8406e68940a9ac8b0e1f813f0f8d
Autor:
Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas Bueno-de-Mesquita, Karina Standahl Olsen, Torkjel Manning Sandanger, Therese Haugdahl Nøst, J. Ramón Quirós, Catalina Bonet, Miguel Rodríguez Barranco, María-Dolores Chirlaque, Eva Ardanaz, Malte Sandsveden, Jonas Manjer, Linda Vidman, Matilda Rentoft, David Muller, Kostas Tsilidis, Alicia K. Heath, Hector Keun, Jerzy Adamski, Pekka Keski-Rahkonen, Augustin Scalbert, Marc J. Gunter, Vivian Viallon
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially assoc
Externí odkaz:
https://doaj.org/article/075752f9504749cebdfd529d2759a4ef
Autor:
Anastasiia Driuchina, Jukka Hintikka, Marko Lehtonen, Pekka Keski-Rahkonen, Thomas O’Connell, Risto Juvonen, Juho Kuula, Antti Hakkarainen, Jari A. Laukkanen, Elina Mäkinen, Sanna Lensu, Kirsi H. Pietiläinen, Satu Pekkala
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Numerous studies have described specific metabolites as biomarkers of severe liver diseases, but very few have measured gut microbiota (GM)-produced metabolites in fatty liver disease. We aimed at finding GM signatures and metabolite markers
Externí odkaz:
https://doaj.org/article/200b28e16b104830bfbe386a512b0acf
Autor:
Jennifer Ose, Biljana Gigic, Stefanie Brezina, Tengda Lin, Anita R. Peoples, Pauline P. Schobert, Andreas Baierl, Eline van Roekel, Nivonirina Robinot, Audrey Gicquiau, David Achaintre, Augustin Scalbert, Fränzel J. B. van Duijnhoven, Andreana N. Holowatyj, Tanja Gumpenberger, Petra Schrotz-King, Alexis B. Ulrich, Arve Ulvik, Per-Magne Ueland, Matty P. Weijenberg, Nina Habermann, Pekka Keski-Rahkonen, Andrea Gsur, Dieuwertje E. Kok, Cornelia M. Ulrich
Publikováno v:
Cancers, Vol 15, Iss 13, p 3391 (2023)
Colorectal cancer (CRC) is increasingly recognized as a heterogeneous disease. No studies have prospectively examined associations of blood metabolite concentrations with all-cause mortality in patients with colon and rectal cancer separately. Target
Externí odkaz:
https://doaj.org/article/4f62e91092ed43f8bdd609bda3c19f2f
Publikováno v:
Frontiers in Public Health, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/fa63c2e229e443518bf091d606e4398e