Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Pekka Jaako"'
Autor:
Hana Komic, Malin S. Nilsson, Lovisa Wennström, Tagore Sanketh Bandaru, Pekka Jaako, Kristoffer Hellstrand, Fredrik B. Thorén, Anna Martner
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Hydroxyurea (HU) is frequently used in the early phase of chronic myeloid leukemia (CML) to achieve cytoreduction prior to tyrosine kinase inhibitor (TKI) therapy. However, its impact on CML stem and progenitor cells (SPC) remains largely unknown. Th
Externí odkaz:
https://doaj.org/article/f23234d23bb942d0bf1e71632bf7b0e2
Autor:
Pekka Jaako, Alexandre Faille, Shengjiang Tan, Chi C. Wong, Norberto Escudero-Urquijo, Pablo Castro-Hartmann, Penny Wright, Christine Hilcenko, David J. Adams, Alan J. Warren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Jaako et al. discover a conserved tier of translational control that dynamically couples ribosome assembly and recycling. This mechanism is corrupted in an inherited bone marrow failure disorder associated with an increased risk of blood cancer.
Externí odkaz:
https://doaj.org/article/453b7a70084349bea9b8597caaa6ef1f
Autor:
Amol Ugale, Gudmundur L. Norddahl, Martin Wahlestedt, Petter Säwén, Pekka Jaako, Cornelis Jan Pronk, Shamit Soneji, Jörg Cammenga, David Bryder
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1246-1255 (2014)
Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenc
Externí odkaz:
https://doaj.org/article/c4741b7b55ce4fbab0fbd79d05e03d44
Autor:
Pekka Jaako, Shubhranshu Debnath, Karin Olsson, Ute Modlich, Michael Rothe, Axel Schambach, Johan Flygare, Stefan Karlsson
Publikováno v:
Haematologica, Vol 99, Iss 12 (2014)
Diamond-Blackfan anemia is a congenital erythroid hypoplasia caused by functional haploinsufficiency of genes encoding ribosomal proteins. Mutations involving the ribosomal protein S19 gene are detected in 25% of patients. Enforced expression of ribo
Externí odkaz:
https://doaj.org/article/5a9913a8d8b3484388c2a0e9653e53da
Publikováno v:
bioRxiv
The ability of ribosomes to translate the genetic code into protein requires a finely tuned ion and solvent ecosystem. However, the lack of high-resolution structures has precluded accurate positioning of all the functional elements of the ribosome a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70db150347dbfa1c67e45b2015bedb8
https://doi.org/10.1101/2023.02.28.530191
https://doi.org/10.1101/2023.02.28.530191
Despite the advanced understanding of disease mechanisms, the current therapeutic regimen fails to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of protein synthesis control in AML leukemia stem cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a4f380567b00efcf5d2e32cd1255da
https://doi.org/10.1101/2023.01.22.525120
https://doi.org/10.1101/2023.01.22.525120
Autor:
Pablo Castro-Hartmann, Shengjiang Tan, Penny Wright, David J. Adams, Alexandre Faille, Christine Hilcenko, Norberto Escudero-Urquijo, Pekka Jaako, Alan J. Warren, Chi C. Wong
Protein synthesis is a cyclical process consisting of translation initiation, elongation, termination and ribosome recycling. The release factors SBDS and EFL1 (both mutated in the leukaemia predisposition disorder Shwachman-Diamond syndrome) license
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e45e8774752f2a669f538203b3da057
https://doi.org/10.1101/2021.09.06.459071
https://doi.org/10.1101/2021.09.06.459071
Autor:
Dana Ranta, Jean Donadieu, Pekka Jaako, Alan J. Warren, Etienne Lengliné, Laetitia Kermasson, Christine Bellanné-Chantelot, Angela Hoslin, Alexandre Faille, Hubert Ducou Le Pointe, Patrick Revy, Abraham Acevedo-Arozena, Christine Bole-Feysot, Caroline Kannengiesser, Blandine Beaupain, Shengjiang Tan, Patrick Nitschke, Odile Fenneteau, Jean-Pierre de Villartay, Stefano Fumagalli, Maryline Poirée
Publikováno v:
Blood
Blood, American Society of Hematology, 2019, 134 (3), pp.277-290. ⟨10.1182/blood.2018893404⟩
Blood, American Society of Hematology, 2019, 134 (3), pp.277-290. ⟨10.1182/blood.2018893404⟩
Shwachman-Diamond syndrome (SDS) is a recessive disorder typified by bone marrow failure and predisposition to hematological malignancies. SDS is predominantly caused by deficiency of the allosteric regulator Shwachman-Bodian-Diamond syndrome that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb653f416e3aa410880bc9b4919cbdd
https://hal.archives-ouvertes.fr/hal-02347758
https://hal.archives-ouvertes.fr/hal-02347758
Autor:
Stefan Karlsson, Pekka Jaako, Jun Chen, H. Bobby Gaspar, Johan Flygare, Axel Schambach, Kavitha Siva, Maria Dahl, Shubhranshu Debnath, Michael Rothe
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 25(8)
Diamond-Blackfan anemia is a congenital erythroid hypoplasia and is associated with physical malformations and a predisposition to cancer. Twenty-five percent of patients with Diamond-Blackfan anemia have mutations in a gene encoding ribosomal protei
Publikováno v:
Blood. 120:2225-2228
Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes encoding for ribosomal proteins. Recently, a case study reported a patient who became transfusion-independent in response to treatme