Effect of storage on the dissolution rate of a fast-dissolving perphenazine/β-cyclodextrin complex

Autor: Ossi Korhonen, Pekka Jarho, Hanne Ahtiainen, Vesa-Pekka Lehto, Kristiina Järvinen, Ari Kauppinen, Elina Turunen

Publikováno v: Journal of Pharmacy and Pharmacology. 66:367-377

Objective In general, the chemical and physical stability of amorphous cyclodextrin complexes and how storage affects their dissolution rate have not been widely reported. The aim of this study was to evaluate the solid-state stability of a fast-diss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0b4df8f2aae17c721714b0c3b4a0b9
https://doi.org/10.1111/jphp.12174

Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam

Autor: Jouko Savolainen, Marko Lehtonen, Hannu Kokki, Pekka Jarho, Ruut Kaartama

Publikováno v: Journal of Chromatography B. 879:1668-1676

A sensitive and selective gas chromatographic mass spectrometric method for the determination of midazolam and its biologically active metabolite, 1-hydroxymidazolam, in rabbit plasma has been developed and validated. Sample preparation includes mixe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4319fcb5d8a6fd724e8978c1f2c510d7
https://doi.org/10.1016/j.jchromb.2011.04.009

Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine

Autor: Jeffrey N. Hemenway, Sajiv K. Nair, Pekka Jarho, Gunda I. Georg, Valentino J. Stella, David VanderVelde, John T. Henri

Publikováno v: Journal of Pharmaceutical Sciences. 99:1810-1825

N-acyl-urea derivatives of carbamazepine (CBZ) were synthesized through the reactions of iminostilbene with acyl-isocyanates to form N-glycyl-carbamazepine (N-Gly-CBZ, after a deprotection step) or N-acetyl-carbamazepine (N-acetyl-CBZ). N-Gly-CBZ was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcab9f869d918ad46d8065c6f42658e
https://doi.org/10.1002/jps.21952

The Effect of Cyclodextrins on Chemical and Physical Stability of Glucagon and Characterization of Glucagon/γ-CD Inclusion Complexes

Autor: Pekka Keski-Rahkonen, Kim Lambertsen Larsen, Tomi Järvinen, Laura Matilainen, Pekka Jarho, Seppo Auriola, Reinhard Wimmer

Publikováno v: Matilainen, L, Larsen, K L, Wimmer, R, Keski-Rahkonen, P, Auriola, S, Järvinen, T & Jarho, P 2008, ' The effect of cyclodextrins on chemical and physical stability of glucagon and characterization of glucagon/gamma-CD inclusion complexes : ', Journal of Pharmaceutical Sciences, vol. 97, no. 7, pp. 2720-2729 . https://doi.org/10.1002/jps.21209

The purpose of the study was to evaluate the effect of cyclodextrin (CD) complexation on the chemical and physical stability of a polypeptide hormone glucagon and to study the interactions between glucagon and gamma-cyclodextrin molecules in inclusio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4d816b39073608e63cb10df8e28482
https://doi.org/10.1002/jps.21209

Sublingual administration of Δ9-tetrahydrocannabinol/β-cyclodextrin complex increases the bioavailability of Δ9-tetrahydrocannabinol in rabbits

Autor: Jussi Tervonen, Tomi Järvinen, Kristiina Järvinen, Janne Mannila, Pekka Jarho

Publikováno v: Life Sciences. 78:1911-1914

The bioavailability of Delta(9)-tetrahydrocannabinol (THC) was determined after its sublingual administration as solid THC/beta-cyclodextrin (THC/beta-CD) complex, and was compared to oral administration of ethanolic THC, in rabbits. The absolute bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7694ebaeb8632f6edb031d538a8acd1d
https://doi.org/10.1016/j.lfs.2005.08.025