Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Pek Yee, Lum"'
Autor:
Zhewei Shen, Anna Halberg, Jia Yi Fong, Jingyu Guo, Gavin Song, Brent Louie, Gregory R. Luedtke, Viwat Visuthikraisee, Andrew A. Protter, Xiaoying Koh, Taegon Baik, Pek Yee Lum
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract COVID-19, first reported in late 2019, is an ongoing pandemic that has been causing devastation across the globe. Although there are multiple vaccines that can prevent severe symptoms, effective COVID-19 therapeutics are still of importance.
Externí odkaz:
https://doaj.org/article/81404399b2b949d4b11b40029d9e9453
Autor:
Maria A. Lim, Brenton Louie, Daniel Ford, Kyle Heath, Paulyn Cha, Joe Betts-Lacroix, Pek Yee Lum, Timothy L. Robertson, Laura Schaevitz
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Despite a broad spectrum of anti-arthritic drugs currently on the market, there is a constant demand to develop improved therapeutic agents. Efficient compound screening and rapid evaluation of treatment efficacy in animal models of rheumatoid arthri
Externí odkaz:
https://doaj.org/article/8f4f062f84cb4e1baaf343564936162f
Autor:
Zhewei Shen, Anna Halberg, Jia Yi Fong, Jingyu Guo, Gavin Song, Brent Louie, Gregory R. Luedtke, Viwat Visuthikraisee, Andy Protter, Xiaoying Koh, Taegon Baik, Pek Yee Lum
COVID-19 is an ongoing pandemic that has been causing devastation across the globe for over 2 years. Although there are multiple vaccines that can prevent severe symptoms, effective COVID-19 therapeutics are still of importance. Using our proprietary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::062aef351d2b12328e87b6443a94cce3
https://doi.org/10.1101/2022.04.18.488682
https://doi.org/10.1101/2022.04.18.488682
Autor:
I‐Ming Wang, Bin Zhang, Xia Yang, Jun Zhu, Serguei Stepaniants, Chunsheng Zhang, Qingying Meng, Mette Peters, Yudong He, Chester Ni, Deborah Slipetz, Michael A Crackower, Hani Houshyar, Christopher M Tan, Ernest Asante‐Appiah, Gary O'Neill, Mingjuan Jane Luo, Rolf Thieringer, Jeffrey Yuan, Chi‐Sung Chiu, Pek Yee Lum, John Lamb, Yves Boie, Hilary A Wilkinson, Eric E Schadt, Hongyue Dai, Christopher Roberts
Publikováno v:
Molecular Systems Biology, Vol 8, Iss 1, Pp 1-16 (2012)
Abstract Common inflammatome gene signatures as well as disease‐specific signatures were identified by analyzing 12 expression profiling data sets derived from 9 different tissues isolated from 11 rodent inflammatory disease models. The inflammatom
Externí odkaz:
https://doaj.org/article/7f8736e3694946c78134d40fac8a24ec
Autor:
Hua Zhong, John Beaulaurier, Pek Yee Lum, Cliona Molony, Xia Yang, Douglas J Macneil, Drew T Weingarth, Bin Zhang, Danielle Greenawalt, Radu Dobrin, Ke Hao, Sangsoon Woo, Christine Fabre-Suver, Su Qian, Michael R Tota, Mark P Keller, Christina M Kendziorski, Brian S Yandell, Victor Castro, Alan D Attie, Lee M Kaplan, Eric E Schadt
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000932 (2010)
Genome-wide association studies (GWAS) have demonstrated the ability to identify the strongest causal common variants in complex human diseases. However, to date, the massive data generated from GWAS have not been maximally explored to identify true
Externí odkaz:
https://doaj.org/article/ce5771819e0c48389a04a2ee9678fe6e
Autor:
Joe Betts-Lacroix, Brent Louie, Laura Schaevitz, Maria A Lim, Timothy L. Robertson, Ford Daniel J, Pek Yee Lum, Paulyn Cha, Kyle Howard Heath
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 8 (2017)
Frontiers in Pharmacology, Vol 8 (2017)
Despite a broad spectrum of anti-arthritic drugs currently on the market, there is a constant demand to develop improved therapeutic agents. Efficient compound screening and rapid evaluation of treatment efficacy in animal models of rheumatoid arthri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cbe77a052ab66b1c1b55af43a63cad
https://pubmed.ncbi.nlm.nih.gov/29184498
https://pubmed.ncbi.nlm.nih.gov/29184498
Autor:
Hester F. Lingsma, Mary J. Vassar, Gunnar E. Carlsson, Jesse Paquette, David O. Okonkwo, Geoffrey T. Manley, Wayne A. Gordon, Tanya C. Petrossian, John K. Yue, Esther L. Yuh, Alex B. Valadka, Track-Tbi Investigators, Pratik Mukherjee, Tomoo Inoue, Jessica L. Nielson, Marco D. Sorani, Pek Yee Lum, Adam R. Ferguson, Shelly R. Cooper
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0169490 (2017)
PLoS One (print), 12(3):e0169490. Public Library of Science
PLoS ONE
PloS one, vol 12, iss 3
PLoS One (print), 12(3):e0169490. Public Library of Science
PLoS ONE
PloS one, vol 12, iss 3
BACKGROUND:Traumatic brain injury (TBI) is a complex disorder that is traditionally stratified based on clinical signs and symptoms. Recent imaging and molecular biomarker innovations provide unprecedented opportunities for improved TBI precision med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c757fb6782f68c154035628224f7d43
http://europepmc.org/articles/PMC5336356?pdf=render
http://europepmc.org/articles/PMC5336356?pdf=render
Autor:
Gloria C. Koo, Martin S. Springer, Lorraine Malkowitz, Douglas W. Kawka, Kang Cheng, Qi Luo, Serguei Stepaniants, Kenneth K. Wu, Irwin I. Singer, Jeffrey Yuan, Andrew S. Plump, Cheryl B. Le Grand, Jun Zhu, Milana Maletic, Samuel D. Wright, James M. Balkovec, Gloria J.-F. Ding, Sherman T. Waddell, Xia Yang, Rolf Thieringer, Kashmira Shah, Pek Yee Lum, Mingjuan Jane Luo, I-Ming Wang, Anne Hermanowski-Vosatka
Publikováno v:
Physiological Genomics. 45:47-57
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is implicated in the etiology of metabolic syndrome. We previously showed that pharmacological inhibition of 11β-HSD1 ameliorated multiple facets of metabolic syndrome and attenuated atheroscleros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62219a7783ded2299858a49a0cadc560
https://doi.org/10.1152/physiolgenomics.00109.2012
https://doi.org/10.1152/physiolgenomics.00109.2012
Autor:
Eric S. Muise, Pek Yee Lum, Yejun Tan, Harold B. Wood, Peter T. Meinke, Hongyue Dai, John R. Thompson, Richard Raubertas, G. Marie Thompson, Joel Berger, Kenny K. Wong
Publikováno v:
Molecular Pharmacology. 82:68-79
Selective peroxisome proliferator-activated receptor γ (PPARγ) modulators (SPPARγMs) have been actively pursued as the next generation of insulin-sensitizing antidiabetic drugs, because the currently marketed PPARγ full agonists, pioglitazone and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cb61b443630efd8b513651af51b36c
https://doi.org/10.1124/mol.111.076679
https://doi.org/10.1124/mol.111.076679