Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Pejman Soroosh"'
Autor:
Xiao Liu, Kevin Lam, Huayi Zhao, Sadatsugu Sakane, Hyun Young Kim, Alvaro Eguileor, Karin Diggle, Shuai Wu, Raquel Carvalho Gontijo Weber, Pejman Soroosh, Mojgan Hosseini, Kristin Mekeel, David A. Brenner, Tatiana Kisseleva
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102391- (2023)
Summary: Here, we present a protocol for isolating human hepatocytes and neural progenitor cells from normal and nonalcoholic steatohepatitis livers. We describe steps for perfusion for scaled-up liver cell isolation and optimization of chemical dige
Externí odkaz:
https://doaj.org/article/06a0220e8c7f4637ab4455a2add3b85d
Autor:
Christine Quach, Doumet Georges Helou, Meng Li, Benjamin Pierre Hurrell, Emily Howard, Pedram Shafiei-Jahani, Pejman Soroosh, Jing-hsiung James Ou, Babak Razani, Virender Rehan, Omid Akbari
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112990- (2023)
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe clinical disorders that mainly develop from viral respiratory infections, sepsis, and chest injury. Antigen-presenting cells play a pivotal role in propagating
Externí odkaz:
https://doaj.org/article/bbea48a4c930453db7dcc96d68fc6f7d
Autor:
Lauriane Galle-Treger, Doumet Georges Helou, Christine Quach, Emily Howard, Benjamin P. Hurrell, German R. Aleman Muench, Pedram Shafiei-Jahani, Jacob D. Painter, Andrea Iorga, Lily Dara, Juliet Emamaullee, Lucy Golden-Mason, Hugo R. Rosen, Pejman Soroosh, Omid Akbari
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The function of autophagy and how this affects non-alcoholic fatty liver disease is not fully known. Here the authors show that in mice with a targeted disruption of the autophagy pathway in CD11c+ cells, development of NAFLD is accelerated involving
Externí odkaz:
https://doaj.org/article/4ec1fb395b5e428b941df9f0a8344367
Autor:
Pedram Shafiei-Jahani, Benjamin P. Hurrell, Lauriane Galle-Treger, Doumet Georges Helou, Emily Howard, Jacob Painter, Richard Lo, Gavin Lewis, Pejman Soroosh, Omid Akbari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Group 2 innate lymphoid cells (ILC2s) are immune cells present in adipose tissue that contribute to metabolic homeostasis. Here the authors show that Death Receptor 3 (DR3) engagement on ILC2s ameliorates glucose tolerance, protects against insulin-r
Externí odkaz:
https://doaj.org/article/ccb0b1c8242f4157b1256882b0fb6cb3
PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
Autor:
Doumet Georges Helou, Pedram Shafiei-Jahani, Richard Lo, Emily Howard, Benjamin P. Hurrell, Lauriane Galle-Treger, Jacob D. Painter, Gavin Lewis, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
PD-1 is a checkpoint inhibitory immune receptor that restrains proliferation and effector functions of a variety of cells, including ILC2s. Here the authors present a human PD-1 agonist that limits ILC2-dependent allergic airway disease in humanized
Externí odkaz:
https://doaj.org/article/7aaaa31742d140ac9e011cac9002ea8f
Autor:
Emily Howard, Benjamin P. Hurrell, Doumet Georges Helou, Christine Quach, Jacob D. Painter, Pedram Shafiei-Jahani, Marshall Fung, Parkash S. Gill, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
While pulmonary ILC2s represent one of the major tissue-resident innate lymphoid cell populations at steady state and are key drivers of cytokine secretion in their occupational niche, their role in pulmonary cancer progression remains unclear. As th
Externí odkaz:
https://doaj.org/article/ca1ad8c4fd46418c9b41d9a84d201ee2
Autor:
Lauriane Galle-Treger, Ishwarya Sankaranarayanan, Benjamin P. Hurrell, Emily Howard, Richard Lo, Hadi Maazi, Gavin Lewis, Homayon Banie, Alan L. Epstein, Peisheng Hu, Virender K. Rehan, Frank D. Gilliland, Hooman Allayee, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Type-2 innate lymphoid cells (ILC2s) are an immune population secreting Th2 cytokines playing a role in the regulation of adipose metabolic homeostasis. Here the authors show that engagement of GITR, a member of the TNF superfamily, in activated ILC2
Externí odkaz:
https://doaj.org/article/1c23f79b445447f9ae0cd84879992375
Autor:
Benjamin P. Hurrell, Lauriane Galle-Treger, Pedram Shafiei Jahani, Emily Howard, Doumet Georges Helou, Homayon Banie, Pejman Soroosh, Omid Akbari
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4509-4524.e5 (2019)
Summary: Group 2 innate lymphoid cells (ILC2s) can initiate pathologic inflammation in allergic asthma by secreting copious amounts of type 2 cytokines, promoting lung eosinophilia and airway hyperreactivity (AHR), a cardinal feature of asthma. We di
Externí odkaz:
https://doaj.org/article/275eef4d7f354ed0be039de7fff462ce
Autor:
Gavin Lewis, Bowen Wang, Pedram Shafiei Jahani, Benjamin P. Hurrell, Homayon Banie, German R. Aleman Muench, Hadi Maazi, Doumet Georges Helou, Emily Howard, Lauriane Galle-Treger, Richard Lo, Swetha Santosh, Andrew Baltus, Gerrold Bongers, Lani San-Mateo, Frank D. Gilliland, Virender K. Rehan, Pejman Soroosh, Omid Akbari
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Group 2 Innate lymphoid cells (ILC2) contribute significantly to allergic inflammation. However, the role of microbiota on ILC2s remains to be unraveled. Here we show that short chain fatty acids (SCFAs), such as butyrate, derived from fermentation o
Externí odkaz:
https://doaj.org/article/f051906e46cb42208860fc1df5d82ef4
Autor:
Hesam Movassagh, Mary Prunicki, Abhinav Kaushik, Xiaoying Zhou, Diane Dunham, Eric M. Smith, Ziyuan He, German R. Aleman Muench, Minyi Shi, Annika K. Weimer, Shu Cao, Sandra Andorf, Amir Feizi, Michael P. Snyder, Pejman Soroosh, Elizabeth D. Mellins, Kari C. Nadeau
Publikováno v:
Allergy.
The impact of exposure to air pollutants, such as fine particulate matter (PM), on the immune system and its consequences on pediatric asthma are not well understood. We investigated whether the ambient levels of fine PM with aerodynamic diameter ≤