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Akademický článek

Efficient enzymatic synthesis of (S)-1-(3′-bromo-2′-methoxyphenyl)ethanol, the key building block of lusutrombopag

Autor: Yunfeng Cui, Yangyang Ji, Xi Chen, Jianjiong Li, Jinhui Feng, Qing Zhao, Peiyuan Yao, Qiaqing Wu, Dunming Zhu

Publikováno v: Green Synthesis and Catalysis, Vol 4, Iss 3, Pp 268-271 (2023)

(S)-1-(3′-Bromo-2′-methoxyphenyl)ethanol ((S)-1b) is the key precursor for the synthesis of Lusutrombopag. The bioreduction of 1-(3′-bromo-2′-methoxyphenyl)ethanone (1a) offers an attractive method to access this important compound. Through s

Externí odkaz: https://doaj.org/article/9fc5a9b2dfd54143a17bfe2e9fc42b3b

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Akademický článek

Synthesis of α,β-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction

Autor: Yitao Duan, Peiyuan Yao, Yuncheng Du, Jinhui Feng, Qiaqing Wu, Dunming Zhu

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 2245-2251 (2015)

α,β-Unsaturated esters are versatile building blocks for organic synthesis and of significant importance for industrial applications. A great variety of synthetic methods have been developed, and quite a number of them use aldehydes as precursors.

Externí odkaz: https://doaj.org/article/cd2f3413b8fb42ac9e5441a8c2b67754

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Asymmetric Synthesis of Fused-Ring Tetrahydroisoquinolines and Tetrahydro-β-carbolines from 2-Arylethylamines via a Chemoenzymatic Approach

Autor: Linsong Yang, Jianjiong Li, Zefei Xu, Peiyuan Yao, Qiaqing Wu, Dunming Zhu, Yanhe Ma

Publikováno v: Organic Letters. 24:6531-6536

While chiral fused-ring tetrahydroisoquinoline (THIQ) and tetrahydro-β-carboline (THβC) scaffolds have attracted considerable interest due to their wide spectrum of biological activities, the synthesis of optically pure chiral fused-ring THIQs and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6beac12448fe4a1b0bc41d67d618e7
https://doi.org/10.1021/acs.orglett.2c02466

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Chemo-enzymatic synthesis of chiral 3-substituted tetrahydroquinolines by a sequential biocatalytic cascade and Buchwald–Hartwig cyclization

Autor: Zefei Xu, Jinhui Feng, Peiyuan Yao, Qiaqing Wu, Dunming Zhu

Publikováno v: Green Chemistry.

A one-pot bienzymatic cascade was developed to synthesize (S)-N-(3-aryl-2-methylpropyl) prop-2-en-1-amines from α,β-unsaturated aldehydes, and 3-substituted tetrahydroquinolines were prepared via Buchwald–Hartwig amination and deallylation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f0ca888c777e11bad81cf037d715c1c
https://doi.org/10.1039/d3gc00047h

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