Zobrazeno 1 - 10
of 368
pro vyhledávání: '"Peixuan Guo"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 559-571 (2023)
KRAS mutations are one of the most common oncogenic driver mutations in human cancers, including non-small cell lung cancer (NSCLC), and have established roles in cancer pathogenesis and therapeutic resistance. The development of effective inhibitors
Externí odkaz:
https://doaj.org/article/050890c080c3488f8b90fc7156db0162
Autor:
You-Cheng Liao, Tzu-Chun Cheng, Shih-Hsin Tu, Jungshan Chang, Peixuan Guo, Li-Ching Chen, Yuan-Soon Ho
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 351-366 (2023)
Triple-negative breast cancer (TNBC) is highly aggressive with a poor prognosis because of a lack of cell markers as drug targets. α9-Nicotinic acetylcholine receptor (nAChR) is expressed abundantly in TNBC; thus, it is a valuable biomarker for TNBC
Externí odkaz:
https://doaj.org/article/a18fa65abcf64390b5496800e762520a
Autor:
Kousalya Lavudi, Ananya Banerjee, Na Li, Yajing Yang, Shurui Cai, Xuetao Bai, Xiaoli Zhang, Aidan Li, Elsa Wani, Shyh-Ming Yang, Junran Zhang, Ganesha Rai, Floor Backes, Srinivas Patnaik, Peixuan Guo, Qi-En Wang
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract Poly (ADP-ribose) Polymerase (PARP) inhibitors (PARPi) have been approved for both frontline and recurrent setting in ovarian cancer with homologous recombination (HR) repair deficiency. However, more than 40% of BRCA1/2-mutated ovarian canc
Externí odkaz:
https://doaj.org/article/80b14cc6045842018c6954753b4b4d3d
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 4, Pp 1383-1399 (2023)
Exosome is an excellent vesicle for in vivo delivery of therapeutics, including RNAi and chemical drugs. The extremely high efficiency in cancer regression can partly be attributed to its fusion mechanism in delivering therapeutics to cytosol without
Externí odkaz:
https://doaj.org/article/b08dc3dfc06f426996e2c2b54d7aa1a6
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106922- (2023)
Summary: DsDNA translocation through nanoscale pores is generally accomplished by ATPase biomotors. The discovery of the revolving dsDNA translocation mechanism, as opposed to rotation, in bacteriophage phi29 elucidated how ATPase motors move dsDNA.
Externí odkaz:
https://doaj.org/article/6d3cf6ccbc3a420d8d4273ecc07014cf
Publikováno v:
Exploration, Vol 3, Iss 2, Pp n/a-n/a (2023)
Abstract Investigations of the parallel architectures of biomotors in both prokaryotic and eukaryotic systems suggest a similar revolving mechanism in the use of ATP to drive translocation of the lengthy double‐stranded (ds)DNA genomes. This mechan
Externí odkaz:
https://doaj.org/article/632c243aba72479c9082c6d41dfde6e1
Autor:
Lewis Rolband, Damian Beasock, Yang Wang, Yao-Gen Shu, Jonathan D. Dinman, Tamar Schlick, Yaoqi Zhou, Jeffrey S. Kieft, Shi-Jie Chen, Giovanni Bussi, Abdelghani Oukhaled, Xingfa Gao, Petr Šulc, Daniel Binzel, Abhjeet S. Bhullar, Chenxi Liang, Peixuan Guo, Kirill A. Afonin
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6120-6137 (2022)
The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent advanc
Externí odkaz:
https://doaj.org/article/a7b658ecc43d44eeabee93b85ac3c176
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 524-535 (2021)
Small interfering RNA (siRNA) for silencing genes and treating disease has been a dream since ranking as a top Breakthrough of the Year in 2002 by Science. With the recent FDA approval of four siRNA-based drugs, the potential of RNA therapeutics to b
Externí odkaz:
https://doaj.org/article/ed5ea473f666481bb5cddb7778c94544
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 426-435 (2021)
Immunotherapy has become a revolutionary subject in cancer therapy during the past few years. Immune checkpoint-targeting antibodies (Abs) could boost anticancer immune responses. However, certain protein-based immunotherapies revealed side effects a
Externí odkaz:
https://doaj.org/article/937a0125011044adb542724219c55bad
Autor:
Peixuan Guo
Publikováno v:
Protein & Cell, Vol 11, Iss 5, Pp 311-315 (2020)
Externí odkaz:
https://doaj.org/article/7282c04d5c124b76a2f247e89b71d6ec