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Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells.

Autor: Madan E; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. esha.gogna@vcuhealth.org.; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. esha.gogna@vcuhealth.org.; VCU Institute of Molecular Medicine, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. esha.gogna@vcuhealth.org.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. esha.gogna@vcuhealth.org., Palma AM; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; VCU Institute of Molecular Medicine, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal., Vudatha V; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal., Kumar A; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; VCU Institute of Molecular Medicine, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Bhoopathi P; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Wilhelm J; Institute for Lung Health (ILH), Universities Giessen & Marburg Lung Center, German Center for Lung Research (DZL), Justus-Liebig-University Giessen, Giessen, Germany.; Universities Giessen & Marburg Lung Center, German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany., Bernas T; Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA., Martin PC; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bilolikar G; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Gogna A; Collegiate School, Richmond, VA, USA., Peixoto ML; Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.; Champalimaud Center for the Unknown, Lisbon, Portugal., Dreier I; Universities Giessen & Marburg Lung Center, German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany., Araujo TF; Sahlgrenska Center for Cancer Research, Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Garre E; Sahlgrenska Center for Cancer Research, Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Gustafsson A; Sahlgrenska Center for Cancer Research, Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Dorayappan KDP; Division of Gynecologic Oncology, Department of Obstetrics/Gynecology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Mamidi N; Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin, Madison, WI, USA., Sun Z; Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA., Yekelchyk M; Universities Giessen & Marburg Lung Center, German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany., Accardi D; Champalimaud Center for the Unknown, Lisbon, Portugal., Olsen AL; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark., Lin L; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark., Titelman AA; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Bianchi M; Empire Genomics Corp., Depew, NY, USA., Jessmon P; Empire Genomics Corp., Depew, NY, USA., Farid EA; Indiana University School of Medicine-Bloomington, Indiana University, Bloomington, IN, USA.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA., Pradhan AK; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Neufeld L; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Yeini E; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Maji S; VCU Institute of Molecular Medicine, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Pelham CJ; Eurofins Panlabs, Inc., St. Charles, MO, USA., Kim H; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Oh D; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Rolfsnes HO; Molecular Imaging Center, Department of Biomedicine, University of Bergen, Bergen, Norway., Marques RC; Champalimaud Center for the Unknown, Lisbon, Portugal., Lu A; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Nagane M; Department of Biochemistry, School of Veterinary Medicine, Azabu University, Sagamihara, Japan., Chaudhary S; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Gupta K; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Gogna KC; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Bigio A; Champalimaud Center for the Unknown, Lisbon, Portugal., Bhoopathi K; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Mannangatti P; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; VCU Institute of Molecular Medicine, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Achary KG; IMGENEX India Pvt. Ltd., Bhubaneswar, India., Akhtar J; IMGENEX India Pvt. Ltd., Bhubaneswar, India., Belião S; Champalimaud Center for the Unknown, Lisbon, Portugal., Das S; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; VCU Institute of Molecular Medicine, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Correia I; Centro de Química Estrutural, Institute of Molecular Sciences and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal., da Silva CL; Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal., Fialho AM; Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal., Poellmann MJ; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, Madison, WI, USA., Javius-Jones K; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, Madison, WI, USA., Hawkridge AM; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA., Pal S; Innomics Inc., Cambridge, MA, USA., Shree KS; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Rakha EA; Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham, UK.; Nottingham Breast Cancer Research Centre, School of Medicine, Academic Unit for Translational Medical Sciences, University of Nottingham, Nottingham, UK., Khurana S; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Xiao G; Syd Labs, Inc., Hopkinton, MA, USA., Zhang D; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Rijal A; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Lyons C; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Grossman SR; Department of Internal Medicine, Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Turner DP; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Pillappa R; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Prakash K; Department of Orthopedic Surgery, Virginia Commonwealth University, Richmond, VA, USA., Gupta G; VCU Division of Nephrology, Virginia Commonwealth University, VCU School of Medicine, Richmond, VA, USA., Robinson GLWG; PhaseDesign Research, Framingham, MA, USA., Koblinski J; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA., Wang H; Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.; Center for Healthcare Innovation, Stevens Institute of Technology, Hoboken, NJ, USA., Singh G; Abeomics, Inc., San Diego, CA, USA., Singh S; Abeomics, Inc., San Diego, CA, USA., Rayamajhi S; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA., Bacolod MD; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Richards H; Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA., Sayeed S; Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA., Klein KP; Department of Obstetrics and Gynecology, Virginia Commonwealth University, VCU School of Medicine, Richmond, VA, USA., Chelmow D; Department of Obstetrics and Gynecology, Virginia Commonwealth University, VCU School of Medicine, Richmond, VA, USA., Satchi-Fainaro R; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Selvendiran K; Division of Gynecologic Oncology, Department of Obstetrics/Gynecology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Connolly D; Fox Chase Cancer Center Biosample Repository Facility, Philadelphia, PA, USA.; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Thorsen FA; Molecular Imaging Center, Department of Biomedicine, University of Bergen, Bergen, Norway., Bjerkvig R; Molecular Imaging Center, Department of Biomedicine, University of Bergen, Bergen, Norway.; NORLUX Neuro-Oncology Laboratory, Department of Biomedicine, University of Bergen, Bergen, Norway.; Department of Oncology, Luxembourg Institute of Health (LIH), Strassen, Luxembourg.; Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, China., Nephew KP; Indiana University School of Medicine-Bloomington, Indiana University, Bloomington, IN, USA.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA., Idowu MO; Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.; Virginia Commonwealth University Health, Richmond, VA, USA., Kühnel MP; Institute of Pathology, RWTH Aachen University, Aachen, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover Medical School, Hanover, Germany., Moskaluk C; Department of Pathology, University of Virginia, Charlottesville, VA, USA., Hong S; Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin, Madison, WI, USA.; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, Madison, WI, USA.; Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Redmond WL; Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA., Landberg G; Sahlgrenska Center for Cancer Research, Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Lopez-Beltran A; Champalimaud Center for the Unknown, Lisbon, Portugal.; Department of Morphological Sciences, Cordoba University Medical School, Cordoba, Spain.; Departamento de Patología, Centro Clínico Champalimaud, Lisboa, Portugal.; Department of Surgery, Cordoba University Medical School, Cordoba, Spain., Poklepovic AS; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA., Sanyal A; Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA., Fisher PB; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; VCU Institute of Molecular Medicine, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Church GM; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Menon U; MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK., Drapkin R; Penn Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Godwin AK; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.; Kansas Institute for Precision Medicine, University of Kansas Medical Center, Kansas City, KS, USA.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS, USA., Luo Y; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark., Ackermann M; Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Pathology and Molecular Pathology, Helios University Clinic Wuppertal, University of Witten/Herdecke, Wuppertal, Germany., Tzankov A; Institute of Medical Genetics and Pathology, University Hospital Basel and University of Basel, Basel, Switzerland., Mertz KD; Institute of Medical Genetics and Pathology, University Hospital Basel and University of Basel, Basel, Switzerland., Jonigk D; Institute of Pathology, RWTH Aachen University, Aachen, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover Medical School, Hanover, Germany., Tsung A; Department of Surgery, Division of Surgical Oncology, University of Virginia, Charlottesville, VA, USA., Sidransky D; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Trevino J; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Saavedra AP; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Department of Dermatology, VCU School of Medicine, Virginia Commonwealth University, Richmond, VA, USA., Winn R; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, VCU School of Medicine, Virginia Commonwealth University, Richmond, VA, USA., Won KJ; Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA., Moreno E; Champalimaud Center for the Unknown, Lisbon, Portugal., Gogna R; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. rajan.gogna@vcuhealth.org.; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. rajan.gogna@vcuhealth.org.; VCU Institute of Molecular Medicine, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. rajan.gogna@vcuhealth.org.; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. rajan.gogna@vcuhealth.org.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 Dec 09. Date of Electronic Publication: 2024 Dec 09.

Tumor heterogeneity: An oncogenic driver of PDAC progression and therapy resistance under stress conditions.

Autor: Palma AM; Champalimaud Centre for the Unknown, Lisbon, Portugal., Vudatha V; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, United States., Peixoto ML; Champalimaud Centre for the Unknown, Lisbon, Portugal., Madan E; Champalimaud Centre for the Unknown, Lisbon, Portugal; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, United States. Electronic address: esha.madan@research.fchampalimaud.org.

Publikováno v: Advances in cancer research [Adv Cancer Res] 2023; Vol. 159, pp. 203-249. Date of Electronic Publication: 2023 Apr 21.