Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Peiwei Chai"'
Autor:
Hanhan Shi, Hao Tian, Tianyu Zhu, Qili Liao, Chang Liu, Peng Yuan, Yongyun Li, Jie Yang, Chunyan Zong, Shichong Jia, Jing Ruan, Shengfang Ge, Renbing Jia, Peiwei Chai, Shiqiong Xu, Xianqun Fan
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Conjunctival melanoma (CoM) is a potentially devastating tumor that can lead to distant metastasis. Despite various therapeutic strategies for distant metastatic CoM, the clinical outcomes remain unfavorable. Herein, we performed single-cell
Externí odkaz:
https://doaj.org/article/308ff374b615437b9c05b694d34ef349
Autor:
Ai Zhuang, Xiang Gu, Tongxin Ge, Shaoyun Wang, Shengfang Ge, Peiwei Chai, Renbing Jia, Xianqun Fan
Publikováno v:
Cancer Communications, Vol 43, Iss 11, Pp 1185-1206 (2023)
Abstract Background Diversified histone deacetylation inhibitors (HDACis) have demonstrated encouraging outcomes in multiple malignancies. N6‐methyladenine (m6A) is the most prevalent messenger RNA modification that plays an essential role in the r
Externí odkaz:
https://doaj.org/article/4ac9993639d944488fddab79b4e4859c
Autor:
Jie Yu, Ai Zhuang, Xiang Gu, Yu Hua, Ludi Yang, Shengfang Ge, Jing Ruan, Peiwei Chai, Renbing Jia, Xianqun Fan
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-19 (2023)
Abstract Targeting programmed cell death protein ligand 1 (PD-L1) remains one of the most essential immunotherapies in cancer1,2. PD-L1 has been detected in the nucleus in multiple malignancies, playing an oncogenic role independent of immune checkpo
Externí odkaz:
https://doaj.org/article/d4c04d27191c4cfe826fe8c2c4438c17
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 2, Pp 127-141 (2023)
The reversible and precise temporal and spatial regulation of histone lysine methyltransferases (KMTs) is essential for epigenome homeostasis. The dysregulation of KMTs is associated with tumor initiation, metastasis, chemoresistance, invasiveness, a
Externí odkaz:
https://doaj.org/article/0959f7ff2c244cd884fbb25d2ba6f2ee
Autor:
Xiang Gu, Yu Hua, Jie Yu, Ludi Yang, Shengfang Ge, Renbing Jia, Peiwei Chai, Ai Zhuang, Xianqun Fan
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 1, Pp 24-38 (2023)
Uveal melanoma (UM) is the most frequent and life-threatening ocular malignancy in adults. Aberrant histone methylation contributes to the abnormal transcriptome during oncogenesis. However, a comprehensive understanding of histone methylation patter
Externí odkaz:
https://doaj.org/article/82109ba1196e4e51967cb62b7d179289
Publikováno v:
Cancer Communications, Vol 42, Iss 11, Pp 1049-1082 (2022)
Abstract Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their metabolism to meet the high bioenergetic and biosynthetic demands for
Externí odkaz:
https://doaj.org/article/3cdb07b6f7984510b74220b83cb09e51
Autor:
Sipeng Zuo, Lin Li, Xuyang Wen, Xiang Gu, Ai Zhuang, Rui Li, Fuxiang Ye, Shengfang Ge, Xianqun Fan, Jiayan Fan, Peiwei Chai, Linna Lu
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)
Abstract Background The precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism, and is necessary for the maintenance of epigenome homeostasis. Howbeit, the mechanism underlying th
Externí odkaz:
https://doaj.org/article/9dfcf965c6de4f6f9faa0e3e6632edf1
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-21 (2022)
Abstract Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source of somatic rearrangements, contribu
Externí odkaz:
https://doaj.org/article/95687f0a18d445efac5e38d2cd416232
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization. However, the role of histone lactylation in tumorigenesis remain
Externí odkaz:
https://doaj.org/article/2f6f7c20134b4567afc55a7700ff1f0b
Publikováno v:
Cancer Biology & Medicine, Vol 18, Iss 1, Pp 298-307 (2021)
Objective: Patients with underlying diseases are more vulnerable to coronavirus disease 2019 (COVID-19). The purpose of this study was to investigate cancer incidence in patients with COVID-19 and to determine whether cancer was associated with morta
Externí odkaz:
https://doaj.org/article/d7a4bbd7e3224293ad3bd9b1d1a513e2