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INHIBITION OF p53 BY PIFITHRIN-α REDUCES MYOCYTE APOPTOSIS AND LEUKOCYTE TRANSMIGRATION IN AGED RAT HEARTS FOLLOWING 24 HOURS OF REPERFUSION

Autor: Peitan Liu, Carl E. Hock, Baohuan Xu, Thomas A. Cavalieri

Publikováno v: Shock. 30:545-551

Ischemic heart disease is a common age-related disease. Apoptotic cell death and inflammation are the major contributors to I/R injury. The mechanisms that trigger myocyte apoptosis and inflammation during myocardial I/R (MI/R) remain to be elucidate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f06c0f8a3633fab4d665a25593135b
https://doi.org/10.1097/shk.0b013e31816a192d

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PIFITHRIN-α ATTENUATES P53-MEDIATED APOPTOSIS AND IMPROVES CARDIAC FUNCTION IN RESPONSE TO MYOCARDIAL ISCHEMIA/REPERFUSION IN AGED RATS

Autor: Thomas A. Cavalieri, Carl E. Hock, Baohuan Xu, Peitan Liu

Publikováno v: Shock. 26:608-614

Ischemic cardiovascular disease is a common age-related disease. The p53-dependent cardiac myocyte apoptosis induced by myocardial ischemia/reperfusion (MI/R) is an important feature in the progression of ischemic heart disease. In the present studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d986d47bd7765058a5d2fa2c52616c25
https://doi.org/10.1097/01.shk.0000232273.11225.af

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Attenuation of antioxidative capacity enhances reperfusion injury in aged rat myocardium after MI/R

Autor: Baohuan Xu, Peitan Liu, Carl E. Hock, Thomas A. Cavalieri

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 287:H2719-H2727

Mortality due to ischemic cardiovascular diseases is significantly higher in elderly than in young adults. Myocardial ischemia-reperfusion (MI/R) can induce oxidative stress and an inflammatory response. We hypothesized that increased vulnerability o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54aa5be39c725ae6f3adf1f4ea16b8f0
https://doi.org/10.1152/ajpheart.00317.2004

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L-Name Enhances Microcirculatory Congestion and Cardiomyocyte Apoptosis During Myocardial Ischemia-Reperfusion in Rats

Autor: Peitan Liu, Baohuan Xu, Lloyd J Forman, Carl E. Hock, Rocco V. Carsia

Publikováno v: Shock. 17:185-192

Besides necrosis, apoptosis is the other major mode of cardiomyocyte loss in ischemic cardiovascular disease. In the present study, we examined the hypothesis that nitric oxide (NO) protects myocardial function by improving myocardial microcirculatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c099b1600279a6739ac9977f91a4b97b
https://doi.org/10.1097/00024382-200203000-00005

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[Untitled]

Autor: K. Yin, R. G. Nagele, P. Y.-K. Wong, L. J. Forman, Peitan Liu

Publikováno v: Neurochemical Research. 23:141-148

The effect of ischemia produced by bilateral occlusion of the common carotid arteries (30 min) followed by 4 hours of reperfusion on total and inducible nitric oxide synthase (NOS) activity and the production of nitric oxide (NO), superoxide and pero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d424ecd2958df7e1902eaf3dbe3cb9f0
https://doi.org/10.1023/a:1022468522564

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Neutrophil-induced lung damage after hepatic ischemia and endotoxemia

Autor: Peitan Liu, G. M. Mcguire, Hartmut Jaeschke

Publikováno v: Free Radical Biology and Medicine. 20:189-197

Administration of Salmonella enteritidis endotoxin (0.5 mg ET/kg) during reperfusion (RP) after short-term hepatic ischemia (20 min) caused severe liver injury induced by Kupffer cells and neutrophils and a high mortality rate. To investigate potenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242dd66d8df5733c318e36e2769fe9a6
https://doi.org/10.1016/0891-5849(95)02028-4

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ACTIVATION OF KUPFFER CELLS AND NEUTROPHILS FOR REACTIVE OXYGEN FORMATION IS RESPONSIBLE FOR ENDOTOXIN-ENHANCED LIVER INJURY AFTER HEPATIC ISCHEMIA

Autor: C. Wayne Smith, Hartmut Jaeschke, G. M. Mcguire, Michael Fisher, Peitan Liu, Anwar Farhood

Publikováno v: Shock. 3:56-62

The potential role of reactive oxygen species generated by Kupffer cells and neutrophils was investigated in a model of endotoxin-enhanced liver injury after hepatic ischemia. Male Fischer rats were subjected to 20 min ischemia and reperfusion of up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc87e1a8221ac0ab0aa83210c6a7ba4c
https://doi.org/10.1097/00024382-199501000-00010

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