Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Peirson SN"'
Autor:
Yamagata, T, Kahn, MC, Prius-Mengual, J, Meijer, E, Šabanović, M, Guillaumin, MCC, van der Vinne, V, Huang, Y-G, McKillop, LE, Jagannath, A, Peirson, SN, Mann, EO, Foster, RG, Vyazovskiy, VV
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Our current understanding of how sleep is regulated is based upon the model of sleep homeostasis, which defines a variable called Process S as a measure of sleep need, and a so-called “flip-flop” model of state switching, which build
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df2ce54d4ef53308055410727580ddb
https://doi.org/10.1073/pnas.2101580118
https://doi.org/10.1073/pnas.2101580118
Publikováno v:
Human Molecular Genetics
Melanopsin (OPN4) is an opsin photopigment expressed within intrinsically photosensitive retinal ganglion cells (ipRGCs) that mediate non-image forming (NIF) responses to light. Two single-nucleotide polymorphisms (SNPs) in human melanopsin (hOPN4),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f27f033724e1cecf7f43230d8b21fcd1
http://europepmc.org/articles/PMC6048994
http://europepmc.org/articles/PMC6048994
Publikováno v:
Current Opinion in Behavioral Sciences
Current opinion in behavioral sciences
Current opinion in behavioral sciences
Our visual perception of the world - seeing form and colour or navigating the environment - depends on the interaction of light and matter in the environment. Light also has a more fundamental role in regulating rhythms in physiology and behaviour, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd3976465d869631d1f358bc9b2dee1
https://doi.org/10.1016/j.cobeha.2019.06.006
https://doi.org/10.1016/j.cobeha.2019.06.006
Publikováno v:
Human Molecular Genetics
Circadian deficits in Huntington’s disease (HD) are recapitulated in both fragment (R6/2) and full-length (Q175) mouse models of HD. Circadian rhythms are regulated by the suprachiasmatic nuclei (SCN) in the hypothalamus, which are primarily entrai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e449f701c66775a2c3b4555dbc27b410
http://europepmc.org/articles/PMC5418835
http://europepmc.org/articles/PMC5418835
Autor:
Pritchett, D, Taylor, A, Barkus, C, Engle, S, Brandon, N, Sharp, T, Foster, R, Harrison, P, Peirson, SN, Bannerman, D
Publikováno v:
The European Journal of Neuroscience
A common strategy when searching for cognitive‐enhancing drugs has been to target the N‐methyl‐d‐aspartate receptor (NMDAR), given its putative role in synaptic plasticity and learning. Evidence in favour of this approach has come primarily f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c485f66b2903a228397e719ee31e9b42
http://europepmc.org/articles/PMC4855640
http://europepmc.org/articles/PMC4855640
Healthy ageing is associated with marked effects on sleep, including its daily amount and architecture, as well as the specific electroencephalogram (EEG) oscillations. Neither the neurophysiological underpinnings, nor the biological significance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4cdc2a20a77ebbf05f2ae0bd4838d474
https://doi.org/10.1523/jneurosci.2513-17.2018
https://doi.org/10.1523/jneurosci.2513-17.2018
Publikováno v:
Scientific Reports.
Two-pore domain (K2P) potassium channels perform essential roles in neuronal function. These channels produce background leak type potassium currents that act to regulate resting membrane potential and levels of cellular excitability. 15 different K2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ddf5924845b6ae9ed5d7a5c44230e24
Autor:
Yavari, A, Stocker, CJ, Ghaffari, S, Wargent, ET, Steeples, V, Czibki, G, Pinter, K, Bellahcene, M, Oliver, PL, Stockenhuber, A, Nguyen, C, Lazdam, M, Kyriakou, T, Parnis, J, Sarma, D, Katritsis, G, Wortmann, DJ, Harper, AR, Brown, LA, Peirson, SN, Redwood, C, Watkins, H, Ashrafian, H
Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed as an attractive strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7f8a993f70ceb9bcf64ae485cff272e7
https://doi.org/10.1016/j.cmet.2016.04.003
https://doi.org/10.1016/j.cmet.2016.04.003
Publikováno v:
Scientific Reports Scientific Reports.
Gnat−/−, Cnga3−/−, Opn4−/− triple knockout (TKO) mice lack essential components of phototransduction signalling pathways present in rods, cones and photosensitive retinal ganglion cells (pRGCs), and are therefore expected to lack all sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::4595477494344fd168f2f9c17e6ba858
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
Progress in Brain Research. 199
Melanopsin expressing retinal ganglion cells represent a third class of ocular photoreceptors and are involved in irradiance detection and non-image-forming responses to light including pupil constriction, circadian entrainment, and regulation of sle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6d7a30b1c5479a019ddc108efef7a3a8
http://ora.ox.ac.uk/objects/uuid:b9cba587-c076-4255-adee-aee447ffeede
http://ora.ox.ac.uk/objects/uuid:b9cba587-c076-4255-adee-aee447ffeede