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Serglycin-Deficiency Causes Reduced Weight Gain and Changed Intestinal Cytokine Responses in Mice Infected With Giardia intestinalis

Autor: Li, Zhiqiang, Peirasmaki, Dimitra, Svard, Staffan, Abrink, Magnus, Åbrink, Magnus

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

The proteoglycan serglycin (SG) is expressed by different innate and adaptive immune cells, e.g. mast cells, macrophages, neutrophils, and cytotoxic T lymphocytes, where SG contributes to correct granule storage and extracellular activity of inflamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbfaf28198d7791148aeba1e1973e68
http://europepmc.org/articles/PMC8316049

High Cysteine Membrane Proteins (HCMPs) Are Up-Regulated DuringGiardia-Host Cell Interactions

Autor: Peirasmaki, Dimitra, Ma'ayeh, Showgy Y., Xu, Feifei, Ferella, Marcela, Campos, Sara, Liu, Jingyi, Svärd, Staffan

Giardia intestinaliscolonizes the upper small intestine of humans and animals, causing the diarrheal disease giardiasis. This unicellular eukaryotic parasite is not invasive but it attaches to the surface of small intestinal epithelial cells (IECs),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ade502465c831ba402b0def60945f0ad
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421261

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Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines

Autor: Liu, Jingyi, Ma'ayeh, Showgy, Peirasmaki, Dimitra, Lundström-Stadelmann, Britta, Hellman, Lars, Svärd, Staffan G.

Publikováno v: Virulence, Vol 9, Iss 1, Pp 879-894 (2018)
Virulence
Liu, Jingyi; Ma'ayeh, Showgy; Peirasmaki, Dimitra; Lundström-Stadelmann, Britta; Hellman, Lars; Svärd, Staffan G. (2018). Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines. Virulence, 9(1), pp. 879-894. Taylor & Francis 10.1080/21505594.2018.1451284

Giardiasis is a common diarrheal disease caused by the protozoan parasite Giardia intestinalis. Cysteine proteases (CPs) are acknowledged as virulence factors in Giardia but their specific role in the molecular pathogenesis of disease is not known. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92f8051fc8b243da95c1c3571531c51