Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Peiquan Zhang"'
Autor:
Ding Yan, Xiaofen Li, Qianqian Yang, Qingtian Huang, Leyi Yao, Peiquan Zhang, Wenshuang Sun, Shuhui Lin, Q. Ping Dou, Jinbao Liu, Xin Chen
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Deubiquitinates (DUBs) have been suggested as novel promising targets for cancer therapies. Accumulating experimental evidence suggests that some metal compounds have the potential to induce cancer cell death via inhibition of DUBs. We previ
Externí odkaz:
https://doaj.org/article/2c8b1a05ab164a05a04b01ecac564e6d
Autor:
Lu Liang, Jijun Fu, Siran Wang, Huiyu Cen, Lingmin Zhang, Safur Rehman Mandukhail, Lingran Du, Qianni Wu, Peiquan Zhang, Xiyong Yu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 1036-1046 (2020)
MiR-142-3p has been reported to act as a tumor suppressor in breast cancer. However, the regulatory effect of miR-142-3p on drug resistance of breast cancer cells and its underlying mechanism remain unknown. Here, we found that miR-142-3p was signifi
Externí odkaz:
https://doaj.org/article/6773c323084a4d86a484a57ae75bcbe3
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 159-172 (2019)
Background: Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases. Through counteracting ubiquitination, deubiquitinases (DUBs
Externí odkaz:
https://doaj.org/article/ea4fe31302844726b0e5e8cf2ee027e8
Autor:
Li Yang, Xin Chen, Qianqian Yang, Jinghong Chen, Qingtian Huang, Leyi Yao, Ding Yan, Jiawen Wu, Peiquan Zhang, Daolin Tang, Nanshan Zhong, Jinbao Liu
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Proteasomal deubiquitinase (DUB) inhibition has been found to be effective in experimental cancer therapy by inducing proteasome inhibition and apoptosis. Ferroptosis is a form of regulated cell death characterized by an iron-dependent lipid peroxida
Externí odkaz:
https://doaj.org/article/580aa6a2490e4bf6a8b852e150bf7576
Autor:
Jinghong Chen, Xin Chen, Dacai Xu, Li Yang, Zhenjun Yang, Qianqian Yang, Ding Yan, Peiquan Zhang, Du Feng, Jinbao Liu
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Ubiquitin–proteasome system (UPS) and autophagy–lysosome pathway (ALP) are two major systems for protein quality control (PQC) in eukaryotic cells. Interconnectivity between these two pathways has been suggested, but the molecular detail of how t
Externí odkaz:
https://doaj.org/article/09e5948d1de44225972f2e4b66c21572
Autor:
Xin Chen, Qianqian Yang, Jinghong Chen, Peiquan Zhang, Qingtian Huang, Xiaolan Zhang, Li Yang, Dacai Xu, Chong Zhao, Xuejun Wang, Jinbao Liu
Publikováno v:
Cellular Physiology and Biochemistry, Vol 49, Iss 2, Pp 780-797 (2018)
Background/Aims: The ubiquitin proteasome system (UPS) is responsible for the degradation of most intracellular proteins, and proteasomal deubiquitinases (DUBs) have recently been highlighted as novel anticancer targets. It is well documented that co
Externí odkaz:
https://doaj.org/article/fbb04df17ff54b529ec415672a1ba0b4
Autor:
Xiaoying Lan, Chong Zhao, Xin Chen, Peiquan Zhang, Dan Zang, Jinjie Wu, Jinghong Chen, Huidan Long, Li Yang, Hongbiao Huang, Bing Z. Carter, Xuejun Wang, Xianping Shi, Jinbao Liu
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-16 (2016)
Abstract Background Acquired imatinib (IM) resistance is frequently characterized by Bcr-Abl mutations that affect IM binding and kinase inhibition in patients with chronic myelogenous leukemia (CML). Bcr-Abl-T315I mutation is the predominant mechani
Externí odkaz:
https://doaj.org/article/6a760931cb8b455fb7a78fca14f3bc84
Autor:
Wenhao Wu, Xintong Liang, Guoquan Xie, Langdi Chen, Weixiong Liu, Guolin Luo, Peiquan Zhang, Lihong Yu, Xuehua Zheng, Hong Ji, Chao Zhang, Wei Yi
Publikováno v:
Molecules, Vol 23, Iss 10, p 2540 (2018)
A series of novel ligustrazine derivatives 8a–r were designed, synthesized, and evaluated as multi-targeted inhibitors for anti-Alzheimer’s disease (AD) drug discovery. The results showed that most of them exhibited a potent ability to inhibit bo
Externí odkaz:
https://doaj.org/article/eb782a72899441408b0ec518370d0ece
Autor:
Zhuo Chen, Ping Lu, Deyu Hu, Wei Xue, Linhong Jin, Song Yang, Baoan Song, Gangfang Xu, Peiquan Zhang, Guiping Ouyang
Publikováno v:
Molecules, Vol 11, Iss 6, Pp 383-392 (2006)
A simple, efficient, and general method has been developed for the synthesis ofvarious 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkylbromides under phase transfer catalysis condition. The structures of the compounds were
Externí odkaz:
https://doaj.org/article/f1dbefc14f014042ab6b3e47afc12187
Autor:
Dailong Zha, Yuanzhi Li, Yingqi Luo, Yingfan Liu, Zehong Lin, Chujie Lin, Siyue Chen, Jiangping Wu, Lihong Yu, Shaobin Chen, Peiquan Zhang, Wenhao Wu, Chao Zhang
Publikováno v:
RSC Medicinal Chemistry. 13:1082-1099
Flavonoid-based amide 7t possesses excellent cytotoxicity against MDA-MB-231 cells and its antitumor activity is achieved by affecting the PI3K/AKT pathway with inducing apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f6495bd01d6db9e400cc4cb9fbeb14d
https://doi.org/10.1039/d2md00148a
https://doi.org/10.1039/d2md00148a