Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Peilu Song"'
Autor:
Peilu Song, Fan Zhao, Dahong Li, Jiqiang Qu, Miao Yao, Yuan Su, Hanxun Wang, Miaomiao Zhou, Yujie Wang, Yinli Gao, Feng Li, Dongmei Zhao, Fengjiao Zhang, Yu Rao, Mingyu Xia, Haitao Li, Jian Wang, Maosheng Cheng
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 6, Pp 2905-2922 (2022)
The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallography and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivat
Externí odkaz:
https://doaj.org/article/f8f315b4d41341e19ffcb1ea0a529a41
Autor:
Ming He, Chaoguo Cao, Zhihao Ni, Yongbo Liu, Peilu Song, Shuang Hao, Yuna He, Xiuyun Sun, Yu Rao
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-64 (2022)
Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-degradation strategy that has emerged in recent years. It uses bifunctional small molecules to induce the ubiquitination and degradation of target proteins through the ubiq
Externí odkaz:
https://doaj.org/article/6610e26ab97a42a3b375b9f85e9f863c
Publikováno v:
Expert Opinion on Therapeutic Patents. 31:977-987
Introduction: The Ser/Thr protein kinase PAK4 is a downstream regulator of Cdc42, mediating cytoskeleton remodeling, and cell motility, and inhibiting apoptosis and transcriptional regulation. Nowa...
Autor:
Peilu Song, Fan Zhao, Dahong Li, Jiqiang Qu, Miao Yao, Yuan Su, Hanxun Wang, Miaomiao Zhou, Yujie Wang, Yinli Gao, Feng Li, Dongmei Zhao, Fengjiao Zhang, Yu Rao, Mingyu Xia, Haitao Li, Jian Wang, Maosheng Cheng
Publikováno v:
Acta pharmaceutica Sinica. B. 12(6)
The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallography and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1
Publikováno v:
Journal of Separation Science. 40:2999-3007
Chiral separation of 12 pairs of basic analyte enantiomers including oxybutynin, bambuterol, tradinterol, clenbuterol, clorprenaline, terbutaline, tulobuterol, citalopram, phencynonate, fexofenadine, salbutamol and penehyclidine was conducted by capi
Publikováno v:
Physical chemistry chemical physics : PCCP. 21(43)
Understanding the selectivity mechanisms of inhibitors towards highly similar proteins is extremely important work on the way to a new drug. Here, we aim to reveal the selectivity mechanisms of type I 1/2 kinase inhibitors towards p21-activated kinas
Publikováno v:
Bioorganic chemistry. 91
p21 activated kinase 4 (PAK4), which belongs to the serine/threonine (Ser/Thr) protein kinase family, is a representative member of the PAK family and plays a significant role in multiple processes associated with cancer development. In this study, s
Understanding the selectivity mechanisms of inhibitors towards highly similar protein kinases is the first step in discovering new selective candidate for satisfactory safety profile. P21-activated kinases (PAKs) are pertain to a family of serine/thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e05c33abdec082958695bf7a9d9670d