Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Peilong Lu"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Clostridioides difficile toxin B (TcdB) is the key virulence factor accounting for C. difficile infection-associated symptoms. Effectively neutralizing different TcdB variants with a universal solution poses a significant challenge. Here we
Externí odkaz:
https://doaj.org/article/b917f138aa8c44e0bd067cd13ae9536a
Autor:
Justin A. Peruzzi, Taylor F. Gunnels, Hailey I. Edelstein, Peilong Lu, David Baker, Joshua N. Leonard, Neha P. Kamat
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Naturally generated lipid nanoparticles termed extracellular vesicles (EVs) hold significant promise as engineerable therapeutic delivery vehicles. However, active loading of protein cargo into EVs in a manner that is useful for delivery rem
Externí odkaz:
https://doaj.org/article/6a7d85c3479547c382c5db225550e86d
Autor:
Dan-Dan Liu, Wenlong Ding, Jin-Tao Cheng, Qiushi Wei, Yinuo Lin, Tian-Yi Zhu, Jing Tian, Ke Sun, Long Zhang, Peilong Lu, Fan Yang, Chao Liu, Shibing Tang, Bing Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Latent bioreactive unnatural amino acids (Uaas) have been widely used in the development of covalent drugs and identification of protein interactors, such as proteins, DNA, RNA and carbohydrates. However, it is challenging to perform high-th
Externí odkaz:
https://doaj.org/article/e13df019d53243888cb83ea62818a3f2
Autor:
Justin A. Peruzzi, Jan Steinkühler, Timothy Q. Vu, Taylor F. Gunnels, Vivian T. Hu, Peilong Lu, David Baker, Neha P. Kamat
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The organization of membrane proteins between and within membrane-bound compartments is critical to cellular function. Yet we lack approaches to regulate this organization in a range of membrane-based materials, such as engineered cells, exo
Externí odkaz:
https://doaj.org/article/dd904c5a265f4a8588ba54371b068b97
Autor:
Qing Zhong, Yanyu Zhao, Fangfei Ye, Zaiyu Xiao, Gaoxingyu Huang, Meng Xu, Yuanyuan Zhang, Xiechao Zhan, Ke Sun, Zhizhi Wang, Shanshan Cheng, Shan Feng, Xiuxiu Zhao, Jizhong Zhang, Peilong Lu, Wenqing Xu, Qiang Zhou, Dan Ma
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
The transmembrane protein Wntless (WLS) is essential for the secretion of Wnt proteins, which are signaling molecules of the Wnt signaling pathways. Here, the authors present the 2.2 Å cryo-EM structure of human WLS in complex with Wnt3a and discuss
Externí odkaz:
https://doaj.org/article/53b7470a0afd4e14a3d033ca7b13b669
Autor:
Parisa Hosseinzadeh, Paris R. Watson, Timothy W. Craven, Xinting Li, Stephen Rettie, Fátima Pardo-Avila, Asim K. Bera, Vikram Khipple Mulligan, Peilong Lu, Alexander S. Ford, Brian D. Weitzner, Lance J. Stewart, Adam P. Moyer, Maddalena Di Piazza, Joshua G. Whalen, Per Jr. Greisen, David W. Christianson, David Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cyclic peptides are of particular interest due to their pharmacological properties, but their design for binding to a target protein is challenging. Here, the authors present a computational “anchor extension” methodology for de novo design of cy
Externí odkaz:
https://doaj.org/article/603d7c9cce674f14a81d38644247320d
Autor:
Justin A. Peruzzi, Taylor F. Gunnels, Hailey I. Edelstein, Peilong Lu, David Baker, Joshua N. Leonard, Neha P. Kamat
Naturally generated lipid nanoparticles termed extracellular vesicles (EVs) hold significant promise as engineerable therapeutic delivery vehicles. However, active loading of protein cargo into EVs in a manner that is useful for delivery remains a ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc7e346d62ee99d806cb69113aca0305
https://doi.org/10.1101/2023.04.29.538810
https://doi.org/10.1101/2023.04.29.538810
Publikováno v:
Third International Conference on Artificial Intelligence and Computer Engineering (ICAICE 2022).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::787c953053493937339ba875891525fc
https://doi.org/10.1117/12.2671040
https://doi.org/10.1117/12.2671040
Publikováno v:
International Conference on Computer Vision, Application, and Algorithm (CVAA 2022).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae52dba08eb0c627b000010e2488b864
https://doi.org/10.1117/12.2673220
https://doi.org/10.1117/12.2673220
Publikováno v:
International Conference on Optics and Machine Vision (ICOMV 2023).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13104a3f15bebe266510a2cf26812165
https://doi.org/10.1117/12.2678808
https://doi.org/10.1117/12.2678808