Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Peihao Chen"'
Autor:
Peihao Chen, Jing Wang, Shuangfeng Zhang, Yan Wang, Yuze Sun, Songlin Bai, Qingcui Wu, Xinyu Cheng, Peng Cao, Xiangbing Qi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Tetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and analgesic effects. Here, we present a scalable asymmetric syntheses of Tetrodotoxin and 9-epiTetrodotoxin from the abundant
Externí odkaz:
https://doaj.org/article/54a6fd8336124dfa8de2de276c4fd6c6
Autor:
Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma, Shuanhu Gao, Xiangbing Qi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
PDE3A modulators for cancer therapy cause serious side effects as they inhibit PDE3A phosphodiesterase activity, which is essential for the maturation of oocytes and the formation of platelets. Here, the authors identify a compound, nauclefine, that
Externí odkaz:
https://doaj.org/article/27c89d5e7ff7496cb22ff33c146a9636
Autor:
Lu Lv, Peihao Chen, Longzhi Cao, Yamei Li, Zhi Zeng, Yue Cui, Qingcui Wu, Jiaojiao Li, Jian-Hua Wang, Meng-Qiu Dong, Xiangbing Qi, Ting Han
Publikováno v:
eLife, Vol 9 (2020)
Molecular-glue degraders mediate interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation. Here, we report a new molecular glue HQ461 discovered by high-throughput screening. Using
Externí odkaz:
https://doaj.org/article/2516480b8dea4d3f9002f19ca4784d02
Autor:
Peihao Chen, Yiqing Yang
Publikováno v:
IEEE/ASME Transactions on Mechatronics. :1-9
Autor:
Jun Yang, Peihao Chen, Yu Cao, Shanshan Liu, Wei Wang, Lin Li, Jiaojiao Li, Zhaodi Jiang, Yan Ma, She Chen, Sanduo Zheng, Xiangbing Qi, Hui Jiang
Publikováno v:
Cell Chemical Biology. 30:278-294.e11
Publikováno v:
IEEE Transactions on Multimedia. 22:2723-2733
Temporal action localization aims to accurately localize and recognize all possible action instances from an untrimmed video automatically. Most existing methods perform this task by first generating a set of proposals and then recognizing each indep
Autor:
Zhangcheng Ding, Wenbin Zhang, Yan Ma, Bo Yan, Yang Cao, Jianzhang Ma, Jiaojiao Li, Peihao Chen, Xiangbing Qi, Jinjie Ou, Jie Chen, Haibing He, Dianrong Li, Shan Du, Jie Zhu, Xiaodong Wang, Youwei Ai, Shuanhu Gao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
The promotion of apoptosis in tumor cells is a popular strategy for developing anti-cancer drugs. Here, we demonstrate that the plant indole alkaloid natural product nauclefine induces apoptosis of diverse cancer cells via a PDE3A-SLFN12 dependent de
Publikováno v:
AAAI
We addressed the challenging task of video question answering, which requires machines to answer questions about videos in a natural language form. Previous state-of-the-art methods attempt to apply spatio-temporal attention mechanism on video frame
Publikováno v:
IEEE Transactions on Image Processing. 28:5797-5808
We address the challenging problem of weakly supervised temporal action localization from unconstrained web videos, where only the video-level action labels are available during training. Inspired by the adversarial erasing strategy in weakly supervi
Autor:
Yanqiu Gong, Dingdong Liu, Zhong Jin, Lin Zhao, Lunzhi Dai, Qingxiang Sun, Baohua Zhang, Peihao Chen, Xia Zhang, Jizhong Lou, Ceshi Chen, Xiangbing Qi, Xiaofei Shen, Da Jia, Dawen Niu
Publikováno v:
J Biol Chem
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) occurs in ∼70% of human cancers, and STAT3 is regarded as one of the most promising targets for cancer therapy. However, specific direct STAT3 inhibitors remain t