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Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes

Autor: Xinchun Wang, Zhongqiu Liu, Lijun Zhu, Huangyu Jiang, Guiyu Zhang, Peimin Dai, Feifei Luo, Ming Hu, Linlin Lu, Liping Wang, Ying Wang

Publikováno v: Biopharmaceutics & Drug Disposition. 36:622-635

Flavonoids occur naturally as glucosides and aglycones. Their common phenolic hydroxyl groups may trigger extensive UDP-glucuronosyltransferase (UGT)- catalysed metabolism. Unlike aglycones, glucosides contain glucose moieties. However, the influence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86f7db259d0e74c7e03d5912ccb10b25
https://doi.org/10.1002/bdd.1989

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A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys

Autor: Hualin Yu, Ning Zhao, Jing He, Lin Zhang, Jianhong Wang, PeiMin Dai, JianZhen Yang, Hui Huang, Xudong Zhao, Lin Yu, LongJiao Ge, Fu-Han Yang

Publikováno v: Scientific Reports

Endothelin-1 (ET-1), a vasoconstrictor, has recently been used to induce focal ischemia in rodents and marmoset monkeys. The rhesus monkey, however, has numerous advantages to the rodent and marmoset that make it a superior and irreplaceable animal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16981d868b2111c9e091bb45050ad11

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Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes

Autor: Peimin, Dai, Feifei, Luo, Ying, Wang, Huangyu, Jiang, Liping, Wang, Guiyu, Zhang, Lijun, Zhu, Ming, Hu, Xinchun, Wang, Linlin, Lu, Zhongqiu, Liu

Publikováno v: Biopharmaceuticsdrug disposition. 36(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2fca78fc952f0332901e4107eabcdfe
https://pubmed.ncbi.nlm.nih.gov/26317684

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UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes

Autor: Peimin Dai, Liang Liu, Zhongqiu Liu, Shan Zeng, Lijun Zhu, Ying Wang, Peng Wu, Ming Hu, Linlin Lu, Feifei Luo

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 43(7)

Esculetin (6,7-dihydroxycoumarin, ET) and 4-methylesculetin (6,7-dihydroxy-4-methylcoumarin, 4-ME) are typical coumarin derivatives that are attracting considerable attention because of their wide spectrum of biologic activities, but their metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b953c943490be44a039e0c1b338c41bb
https://pubmed.ncbi.nlm.nih.gov/25854527

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A combined strategy of mass fragmentation, post-column cobalt complexation and shift in ultraviolet absorption spectra to determine the uridine 5'-diphospho-glucuronosyltransferase metabolism profiling of flavones after oral administration of a flavone mixture in rats

Autor: Ying Wang, Liping Wang, Qiang Li, Peimin Dai, Xiaoxiao Qi, Linlin Lu, Tongmeng Yan, Ming Hu, Zhongqiu Liu, Lijun Zhu, Xinchun Wang, Xuejun Zeng

Publikováno v: Journal of chromatography. A. 1395

The use of dietary flavones is becoming increasingly popular for their prevention of cancers, cardiovascular diseases, and other diseases. Despite many pharmacokinetic studies on flavone mixtures, the position(s) of glucuronidation sites on the flavo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a4909d9fe248328c52d9734a0ccdd5
https://pubmed.ncbi.nlm.nih.gov/25892633

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Multidrug resistance-associated protein 2 is involved in the efflux of Aconitum alkaloids determined by MRP2-MDCKII cells

Autor: Jian Shi, Min Zhao, Xiaoshan Yang, Peimin Dai, Zhongqiu Liu, Linlin Lu, Lijun Zhu, Ying Wang

Publikováno v: Life sciences. 127

Aims Aconitum alkaloids mainly contain highly toxic aconitine (AC), mesaconitine (MA), and hypaconitine (HA) and less toxic benzoylaconine (BAC), benzoylmesaconine (BMA), benzoylhypaconine (BHA), aconine, mesaconine, and hypaconine. The efflux transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f889840b50c959f44575694a997f3859
https://pubmed.ncbi.nlm.nih.gov/25744397

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Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids

Autor: Qiang Li, Zhongqiu Liu, Liping Wang, Lijun Zhu, Linlin Lu, Ming Hu, Ying Wang, Xinchun Wang, Peimin Dai, Feifei Luo

Publikováno v: The AAPS journal. 17(3)

Triple recycling (i.e., enterohepatic, enteric and local recycling) plays a central role in governing the disposition of phenolics such as flavonoids, resulting in low systemic bioavailability but higher gut bioavailability and longer than expected a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b30e458e3adff8767a76b9bc44b422
https://pubmed.ncbi.nlm.nih.gov/25762448

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Pharmacokinetic Comparisons of Benzoylmesaconine in Rats Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry after Administration of Pure Benzoylmesaconine and Wutou Decoction

Autor: Peimin Dai, Ying Wang, Zhijie Zheng, Zhongqiu Liu, Shan Zeng, Qiang Li, Ling Ye, Lin-Liu Lu

Publikováno v: Molecules
Volume 19
Issue 10
Pages 16757-16769
Molecules, Vol 19, Iss 10, Pp 16757-16769 (2014)

Wutou decoction is widely used in China because of its therapeutic effect on rheumatoid arthritis. Benzoylmesaconine (BMA), the most abundant component of Wutou decoction, was used as the marker compound for the pharmacokinetic study of Wutou decocti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c99a6c5f8df9688b877063b84491cb

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