Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Pei-Yin Lim"'
Autor:
Pei-Yin Lim, Appanna Ramapraba, Thomas Loy, Angeline Rouers, Tun-Linn Thein, Yee-Sin Leo, Dennis R Burton, Katja Fink, Cheng-I Wang
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285878 (2023)
Dengue non-structural protein (NS1) is an important diagnostic marker during the acute phase of infection. Because NS1 is partially conserved across the flaviviruses, a highly specific DENV NS-1 diagnostic test is needed to differentiate dengue infec
Externí odkaz:
https://doaj.org/article/b2f9b7c9c6bb40719052860154f52523
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26697 (2011)
Many viruses within the Flavivirus genus cause significant disease in humans; however, effective antivirals against these viruses are not currently available. We have previously shown that a thiopurine drug, 6-methylmercaptopurine riboside (6MMPr), i
Externí odkaz:
https://doaj.org/article/5eb9d68ec6a04e2599f2d0a7a6b0519e
Autor:
Mary Jane Cardosa, Pei-Yin Lim
Publikováno v:
Journal of Virological Methods. 270:113-119
The goal of this paper was to develop a sandwich ELISA that can detect intact human enterovirus A71 (EV-A71) virus-like particles (VLPs) in vaccines. This assay specifically detected EV-A71 viruses from different sub-genogroups as well as EV-A71 VLPs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ed28ed8a07ce04a286603800bb95d7
https://doi.org/10.1016/j.jviromet.2019.05.005
https://doi.org/10.1016/j.jviromet.2019.05.005
Characterizing Enterovirus 71 and Coxsackievirus A16 virus-like particles production in insect cells
Publikováno v:
Methods. 95:38-45
Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) are two viruses commonly responsible for hand, foot and mouth disease (HFMD) in children. The lack of prophylactic or therapeutic measures against HFMD is a major public health concern. Insect cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9361cc8aac3181c4b844cc149b303c1e
https://doi.org/10.1016/j.ymeth.2015.09.023
https://doi.org/10.1016/j.ymeth.2015.09.023
Publikováno v:
Vaccine. 36(45)
A candidate hand, foot, and mouth disease vaccine comprising of human enterovirus A71 (EV-A71) virus-like particles (VLPs) was tested in rabbits to evaluate the potential local and systemic effects of this vaccine. The rabbits received more than doub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93115a337e8b94497e28f7ced7b8d4a
https://pubmed.ncbi.nlm.nih.gov/30293762
https://pubmed.ncbi.nlm.nih.gov/30293762
Immunogenicity and performance of an enterovirus 71 virus-like-particle vaccine in nonhuman primates
Autor:
Andrew C. Hickey, Sharifah Binti Hamid, Joshua A. Kramer, M. Jane Cardosa, Pei-Yin Lim, Mohamad Fakruddin Jamiluddin, Katharine N. Bossart, Rosemary Santos
Publikováno v:
Vaccine. 33:6017-6024
A vaccine against human enterovirus 71 (EV-A71) is urgently needed to combat outbreaks of EV-A71 and in particular, the serious neurological complications that manifest during these outbreaks. In this study, an EV-A71 virus-like-particle (VLP) based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11483b2b3aa75332cd8fde063bbf7552
https://doi.org/10.1016/j.vaccine.2015.05.108
https://doi.org/10.1016/j.vaccine.2015.05.108
Autor:
Rushika Perera, Pavel Plevka, Pei-Yin Lim, Richard J. Kuhn, Jane Cardosa, Ampa Suksatu, Michael G. Rossmann
Publikováno v:
Proceedings of the National Academy of Sciences. 111:2134-2139
Antibodies were prepared by immunizing mice with empty, immature particles of human enterovirus 71 (EV71), a picornavirus that causes severe neurological disease in young children. The capsid structure of these empty particles is different from that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7528eded5c10740a6bfeacc04cf27a
https://doi.org/10.1073/pnas.1320624111
https://doi.org/10.1073/pnas.1320624111
Autor:
Kelly A. Fitzpatrick, Laura D. Kramer, Kristen A. Bernard, Gregory D. Ebel, Pei Yong Shi, Eleanor R. Deardorff, Pei-Yin Lim, Greta V.S. Jerzak, Corey J. Bennett, Yangsheng Zhou
Publikováno v:
Journal of Virology. 85:12605-12613
West Nile virus (WNV) is similar to other RNA viruses in that it forms genetically complex populations within hosts. The virus is maintained in nature in mosquitoes and birds, with each host type exerting distinct influences on virus populations. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d80b498fb504bc3bddd46e8c2f57254
https://doi.org/10.1128/jvi.05637-11
https://doi.org/10.1128/jvi.05637-11
Publikováno v:
Journal of Virology. 85:5197-5201
West Nile virus (WNV) replicates in the skin; however, cell targets in the skin have not been identified. In the current studies, WNV infected the epidermis and adnexal glands of mouse skin, and the epidermal cells were identified as keratinocytes by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89620d6a9fb9d81c3b1311ef294bf188
https://doi.org/10.1128/jvi.02692-10
https://doi.org/10.1128/jvi.02692-10
Publikováno v:
Journal of Virology. 83:11765-11776
Superinfection exclusion is the ability of an established viral infection to interfere with a second viral infection. Using West Nile virus (WNV) as a model, we show that replicating replicons in BHK-21 cells suppress subsequent WNV infection. The WN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae022103e3ecb46a3b1f3e9afa5b0b03
https://doi.org/10.1128/jvi.01205-09
https://doi.org/10.1128/jvi.01205-09