Radiobiological Aspects of FLASH Radiotherapy

Autor: Eline Hageman, Pei-Pei Che, Max Dahele, Ben J. Slotman, Peter Sminia

Publikováno v: Biomolecules, Vol 12, Iss 10, p 1376 (2022)

Radiotherapy (RT) is one of the primary treatment modalities for cancer patients. The clinical use of RT requires a balance to be struck between tumor effect and the risk of toxicity. Sparing normal tissue is the cornerstone of reducing toxicity. Adv

Externí odkaz: https://doaj.org/article/e2225a5bd6cc4f4b8ee067d7bc780e39

Biodegradable Ultrasmall-In-Nano Architectures Loaded with Cisplatin Prodrug in Combination with Ionizing Radiation Induces DNA Damage and Apoptosis in Pancreatic Ductal Adenocarcinoma

Autor: Pei Pei Che, Ana Katrina Mapanao, Alessandro Gregori, Maria Laura Ermini, Agata Zamborlin, Mjriam Capula, Danitsja Ngadimin, Ben J. Slotman, Valerio Voliani, Peter Sminia, Elisa Giovannetti

Publikováno v: Cancers, 14(12):3034. Multidisciplinary Digital Publishing Institute (MDPI)
Che, P P, Mapanao, A K, Gregori, A, Ermini, M L, Zamborlin, A, Capula, M, Ngadimin, D, Slotman, B J, Voliani, V, Sminia, P & Giovannetti, E 2022, ' Biodegradable Ultrasmall-In-Nano Architectures Loaded with Cisplatin Prodrug in Combination with Ionizing Radiation Induces DNA Damage and Apoptosis in Pancreatic Ductal Adenocarcinoma ', Cancers, vol. 14, no. 12, 3034 . https://doi.org/10.3390/cancers14123034
Cancers; Volume 14; Issue 12; Pages: 3034

Considering the dismal survival rate, novel therapeutic strategies are warranted to improve the outcome of pancreatic ductal adenocarcinoma (PDAC). Combining nanotechnology for delivery of chemotherapeutics—preferably radiosensitizing agents—is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea84d54b62b0b0925be87fefff7e2ee
https://research.vumc.nl/en/publications/efee945a-0ef6-4be8-b1f7-2a59c84d94f3

Dietary vitamin K intake in relation to skeletal muscle mass and strength among adults: a cross-sectional study based on NHANES

Autor: Qiong Wang, Pei-pei Chen, Jia-yu Guo, Shi-jia Wang, Yuan-yuan Bao, Yu Zhang, Kang Yu

Publikováno v: Frontiers in Nutrition, Vol 11 (2024)

BackgroundPrevious studies revealed that vitamin K might help maintain muscle homeostasis, but this association has received little attention. We aimed to explore the associations of vitamin K intake with skeletal muscle mass and strength.MethodsWe i

Externí odkaz: https://doaj.org/article/ee10a1098f4d498a8a5a544f3bfc87f8

Tumor grafted - chick chorioallantoic membrane as an alternative model for biological cancer research and conventional/nanomaterial-based theranostics evaluation

Autor: Valerio Voliani, Pei Pei Che, Patrizia Sarogni, Peter Sminia, Ana Katrina Mapanao, Elisa Giovannetti

Publikováno v: Mapanao, A K, Che, P P, Sarogni, P, Sminia, P, Giovannetti, E & Voliani, V 2021, ' Tumor grafted-chick chorioallantoic membrane as an alternative model for biological cancer research and conventional/nanomaterial-based theranostics evaluation ', Expert Opinion on Drug Metabolism and Toxicology, vol. 17, no. 8, pp. 947-968 . https://doi.org/10.1080/17425255.2021.1879047

Introduction: Advancements in cancer management and treatment are associated with strong preclinical research data, in which reliable cancer models are demanded. Indeed, inconsistent preclinical findings and stringent regulations following the 3Rs pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cd71a382fa11aafddcc446e00a01ca
https://research.vumc.nl/en/publications/543dd1a2-6c6a-4b22-88ab-8a12d599ab69

Role of c-MET inhibitors in overcoming drug resistance in spheroid models of primary human pancreatic cancer and stellate cells

Autor: Btissame El Hassouni, Stefano Coppola, Pei Pei Che, Giulia Mantini, Matthias Löhr, Elisa Giovannetti, Niccola Funel, Mark Buijs, Godefridus J. Peters, Thomas Schmidt, Omidreza Firuzi, Amir Avan, Rainer Heuchel, Ilaria Carnevale, Luciano Saso

Publikováno v: Firuzi, O, Che, P P, el Hassouni, B, Buijs, M, Coppola, S, Löhr, M, Funel, N, Heuchel, R, Carnevale, I, Schmidt, T, Mantini, G, Avan, A, Saso, L, Peters, G J & Giovannetti, E 2019, ' Role of c-MET inhibitors in overcoming drug resistance in spheroid models of primary human pancreatic cancer and stellate cells ', Cancers, vol. 11, no. 5, 638 . https://doi.org/10.3390/cancers11050638
Cancers, 11(5):638. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers
Cancers, 11(5), 638. MDPI
Cancers, Vol 11, Iss 5, p 638 (2019)
Volume 11
Issue 5

Pancreatic stellate cells (PSCs) are a key component of tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) and contribute to drug resistance. c-MET receptor tyrosine kinase activation plays an important role in tumorigenesis in differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251399fa85971da2170f85f2e11abbce
https://research.vumc.nl/en/publications/d7fe9129-9bc6-4f81-b1f1-18e41e367ed4