Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Pei-Lun Kuo"'
Autor:
Roshni Roy, Pei-Lun Kuo, Julián Candia, Dimitra Sarantopoulou, Ceereena Ubaida-Mohien, Dena Hernandez, Mary Kaileh, Sampath Arepalli, Amit Singh, Arsun Bektas, Jaekwan Kim, Ann Z Moore, Toshiko Tanaka, Julia McKelvey, Linda Zukley, Cuong Nguyen, Tonya Wallace, Christopher Dunn, William Wood, Yulan Piao, Christopher Coletta, Supriyo De, Jyoti Sen, Nan-ping Weng, Ranjan Sen, Luigi Ferrucci
Publikováno v:
eLife, Vol 12 (2023)
Age-associated DNA methylation in blood cells convey information on health status. However, the mechanisms that drive these changes in circulating cells and their relationships to gene regulation are unknown. We identified age-associated DNA methylat
Externí odkaz:
https://doaj.org/article/d686b4020d774313aa1c545d7788c07b
Autor:
Daniel L. McCartney, Josine L. Min, Rebecca C. Richmond, Ake T. Lu, Maria K. Sobczyk, Gail Davies, Linda Broer, Xiuqing Guo, Ayoung Jeong, Jeesun Jung, Silva Kasela, Seyma Katrinli, Pei-Lun Kuo, Pamela R. Matias-Garcia, Pashupati P. Mishra, Marianne Nygaard, Teemu Palviainen, Amit Patki, Laura M. Raffield, Scott M. Ratliff, Tom G. Richardson, Oliver Robinson, Mette Soerensen, Dianjianyi Sun, Pei-Chien Tsai, Matthijs D. van der Zee, Rosie M. Walker, Xiaochuan Wang, Yunzhang Wang, Rui Xia, Zongli Xu, Jie Yao, Wei Zhao, Adolfo Correa, Eric Boerwinkle, Pierre-Antoine Dugué, Peter Durda, Hannah R. Elliott, Christian Gieger, The Genetics of DNA Methylation Consortium, Eco J. C. de Geus, Sarah E. Harris, Gibran Hemani, Medea Imboden, Mika Kähönen, Sharon L. R. Kardia, Jacob K. Kresovich, Shengxu Li, Kathryn L. Lunetta, Massimo Mangino, Dan Mason, Andrew M. McIntosh, Jonas Mengel-From, Ann Zenobia Moore, Joanne M. Murabito, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Miina Ollikainen, James S. Pankow, Nancy L. Pedersen, Annette Peters, Silvia Polidoro, David J. Porteous, Olli Raitakari, Stephen S. Rich, Dale P. Sandler, Elina Sillanpää, Alicia K. Smith, Melissa C. Southey, Konstantin Strauch, Hemant Tiwari, Toshiko Tanaka, Therese Tillin, Andre G. Uitterlinden, David J. Van Den Berg, Jenny van Dongen, James G. Wilson, John Wright, Idil Yet, Donna Arnett, Stefania Bandinelli, Jordana T. Bell, Alexandra M. Binder, Dorret I. Boomsma, Wei Chen, Kaare Christensen, Karen N. Conneely, Paul Elliott, Luigi Ferrucci, Myriam Fornage, Sara Hägg, Caroline Hayward, Marguerite Irvin, Jaakko Kaprio, Deborah A. Lawlor, Terho Lehtimäki, Falk W. Lohoff, Lili Milani, Roger L. Milne, Nicole Probst-Hensch, Alex P. Reiner, Beate Ritz, Jerome I. Rotter, Jennifer A. Smith, Jack A. Taylor, Joyce B. J. van Meurs, Paolo Vineis, Melanie Waldenberger, Ian J. Deary, Caroline L. Relton, Steve Horvath, Riccardo E. Marioni
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-25 (2021)
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in p
Externí odkaz:
https://doaj.org/article/d9c2f9d64559417981cafac594b7aed0
Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking. Epigenetic age acceleration has been shown to be predictive of many age-associated diseases
Externí odkaz:
https://doaj.org/article/00b352b52bf9412c8daae1ad8d13337a
Autor:
Danielle S. Powell, Pei-Lun Kuo, Riaz Qureshi, Sally B. Coburn, David S. Knopman, Priya Palta, Rebecca Gottesman, Michael Griswold, Marilyn Albert, Jennifer A. Deal, Alden L. Gross
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Objective: To investigate whether APOE ε4 genotype—an established risk factor for dementia—is associated with earlier age at diagnosis in addition to increased risk overall and in secondary analysis by race and sex.Methods: We followed up 13,782
Externí odkaz:
https://doaj.org/article/e20d4b75e6814f989ffc0717a2c4ce7c
Autor:
Ceereena Ubaida-Mohien, Ruin Moaddel, Ann Zenobia Moore, Pei-Lun Kuo, Faraz Faghri, Ravi Tharakan, Toshiko Tanaka, Mike A. Nalls, Luigi Ferrucci
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Human aging is associated with a decline of physical and cognitive function and high susceptibility to chronic diseases, which is influenced by genetics, epigenetics, environmental, and socio-economic status. In order to identify the factors that mod
Externí odkaz:
https://doaj.org/article/6af8d2ecd1754008ad3de8448864ac3c
Publikováno v:
Dermatologica Sinica, Vol 37, Iss 1, Pp 46-49 (2019)
There are limited studies regarding childhood and adolescent psoriasis in Taiwan. A total of 86 pathologically confirmed cases diagnosed from 1989 to 2017 were retrospectively reviewed. Mean disease onset age was 10.51 years, and plaque psoriasis was
Externí odkaz:
https://doaj.org/article/c78a97b510a14bad82e21ea7a511deff
Autor:
Fu-Zong Wu, Pei-Lun Kuo, Yi-Luan Huang, En-Kuei Tang, Chi-Shen Chen, Ming-Ting Wu, Yun-Pei Lin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/212e31fdcf6048b5b1be55ec571f7162
Publikováno v:
PLoS Medicine, Vol 16, Iss 2, p e1002760 (2019)
[This corrects the article DOI: 10.1371/journal.pmed.1002718.].
Externí odkaz:
https://doaj.org/article/4b79213766d24927950dff587f1acc0c
Publikováno v:
PLoS Medicine, Vol 15, Iss 12, p e1002718 (2018)
BackgroundA person's rate of aging has important implications for his/her risk of death and disease; thus, quantifying aging using observable characteristics has important applications for clinical, basic, and observational research. Based on routine
Externí odkaz:
https://doaj.org/article/aa7e36ac89624f128d7641301697e551
Publikováno v:
Nutrients, Vol 12, Iss 10, p 3061 (2020)
Resting metabolic rate (RMR) declines with aging and is related to changes in health status, but how specific health impairments impact basal metabolism over time has been largely unexplored. We analyzed the association of RMR with 15 common age-rela
Externí odkaz:
https://doaj.org/article/3cef84c6c1774a548b55c53cbe926bfa