Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Pei-Chih King"'
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102034- (2024)
Objective: Brown adipose tissue (BAT) plays an important role in mammalian thermogenesis through the expression of uncoupling protein 1 (UCP1). Our previous study identified cytoplasmic polyadenylation element binding protein 2 (CPEB2) as a key regul
Externí odkaz:
https://doaj.org/article/962f591a3e5544abaae4ba165ea9d6ce
Autor:
Heng Lin, Yen-Sung Huang, Jean-Michel Fustin, Masao Doi, Huatao Chen, Hui-Huang Lai, Shu-Hui Lin, Yen-Lurk Lee, Pei-Chih King, Hsien-San Hou, Hao-Wen Chen, Pei-Yun Young, Hsu-Wen Chao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Polyploidy is a common feature in normal hepatocytes, however, the pathophysiological function of hepatic hyperpolyploidy is unclear. Here, the authors show that genotoxic stress induces accumulation of hyperpolyploid hepatocytes around the centrilob
Externí odkaz:
https://doaj.org/article/2a6b0a8610cd4b32b27ac9dde0bc48ce
Publikováno v:
Cells, Vol 11, Iss 6, p 1022 (2022)
Pharmacological studies indicate that Salvia miltiorrhiza extract (SME) can improve cardiac and blood vessel function. However, there is limited knowledge regarding the effects (exerted through epigenetic regulation) of SME and newly derived single c
Externí odkaz:
https://doaj.org/article/b3caceb7d8a54d0597612e376953536a
Autor:
Jean-Michel Fustin, Hao Wen Chen, Masao Doi, Hsu Wen Chao, Pei Yun Young, Hsien San Hou, Shu Hui Lin, Huatao Chen, Pei Chih King, Yen Lurk Lee, Yen Sung Huang, Hui Huang Lai, Heng Lin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Lin, H, Huang, Y-S, Fustin, J-M, Doi, M, Chen, H, Lai, H-H, Lin, S-H, King, P-C, Hou, H-S, Chen, H-W, Young, P-Y & Chao, H-W 2021, ' Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver ', Nature Communications, vol. 12, no. 1, pp. 645 . https://doi.org/10.1038/s41467-020-20572-8
Lin, H, Huang, Y-S, Fustin, J-M, Doi, M, Chen, H, Lai, H-H, Lin, S-H, Lee, Y-L, King, P-C, Hou, H-S, Chen, H-W, Young, P-Y & Chao, H-W 2021, ' Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver ', Nature Communications, vol. 12, no. 1, 645 . https://doi.org/10.1038/s41467-020-20572-8
Lin, H, Huang, Y-S, Fustin, J-M, Doi, M, Chen, H, Lai, H-H, Lin, S-H, King, P-C, Hou, H-S, Chen, H-W, Young, P-Y & Chao, H-W 2021, ' Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver ', Nature Communications, vol. 12, no. 1, pp. 645 . https://doi.org/10.1038/s41467-020-20572-8
Lin, H, Huang, Y-S, Fustin, J-M, Doi, M, Chen, H, Lai, H-H, Lin, S-H, Lee, Y-L, King, P-C, Hou, H-S, Chen, H-W, Young, P-Y & Chao, H-W 2021, ' Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver ', Nature Communications, vol. 12, no. 1, 645 . https://doi.org/10.1038/s41467-020-20572-8
Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region for tumor foci emergence is and how this tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4a90250a26229102d4437b41f7865a
https://doaj.org/article/2a6b0a8610cd4b32b27ac9dde0bc48ce
https://doaj.org/article/2a6b0a8610cd4b32b27ac9dde0bc48ce
Autor:
Hao-Wen Chen, Pei-Chih King, Huatao Chen, Yen-Lurk Lee, Pei-Yun Young, Yen Sung Huang, Hsu Wen Chao, Hui-Huang Lai, Heng Lin, Hsien-San Hou, Shu Hui Lin, Masao Doi, Jean-Michel Fustin
Publikováno v:
Fustin, J-M & Chao, H-W 2020, ' Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver ', bioRxiv . https://doi.org/10.1101/2020.08.23.258699
Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region for tumor foci emergence is and how this tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954ccd8e4a6f19dab60dc3b0b9367502
https://doi.org/10.1101/2020.08.23.258699
https://doi.org/10.1101/2020.08.23.258699
Publikováno v:
Circulation Research. 121:1140-1152
Rationale: Downregulation of Cx43 (connexin 43), the major cardiac gap junction protein, is often associated with arrhythmia, dilated cardiomyopathy (DCM), and heart failure. However, the cause of the reduced expression remains elusive. Reinduction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b09a8373b097dac091ccfc42528b3f5b
https://doi.org/10.1161/circresaha.117.311281
https://doi.org/10.1161/circresaha.117.311281
Publikováno v:
Circulation Research; 10/27/2017, Vol. 121 Issue 10, p1140-1152, 13p