Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Pei Xin Lim"'
Autor:
Daniela Georgieva, Ning Wang, Angelo Taglialatela, Stepan Jerabek, Colleen R. Reczek, Pei Xin Lim, Julie Sung, Qian Du, Michiko Horiguchi, Maria Jasin, Alberto Ciccia, Richard Baer, Dieter Egli
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114006- (2024)
Summary: Reprogramming to pluripotency is associated with DNA damage and requires the functions of the BRCA1 tumor suppressor. Here, we leverage separation-of-function mutations in BRCA1/2 as well as the physical and/or genetic interactions between B
Externí odkaz:
https://doaj.org/article/44e405bad36b4df4b62d48f8744cbc42
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Mutations in homology-directed repair genes likeBRCA2are linked to breast cancer susceptibility. Here the authors generate mice with an inducible DNA break-reporter system and see high levels of homology-directed repair in proliferative mammary tissu
Externí odkaz:
https://doaj.org/article/05628ecc62f8432486b6a2626164ba2c
Autor:
Amy M Lyndaker, Pei Xin Lim, Joanna M Mleczko, Catherine E Diggins, J Kim Holloway, Rebecca J Holmes, Rui Kan, Donald H Schlafer, Raimundo Freire, Paula E Cohen, Robert S Weiss
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003320 (2013)
The RAD9-RAD1-HUS1 (9-1-1) complex is a heterotrimeric PCNA-like clamp that responds to DNA damage in somatic cells by promoting DNA repair as well as ATR-dependent DNA damage checkpoint signaling. In yeast, worms, and flies, the 9-1-1 complex is als
Externí odkaz:
https://doaj.org/article/f93d571755d841129c8f7ce8fd7e1500
Autor:
Rohit Prakash, Jean Gautier, Jennifer Zagelbaum, Kara A. Bernstein, Emilie C B Desclos, Travis White, Przemek M. Krawczyk, Florian Morati, Pei Xin Lim, Raymond Wang, Mauro Modesti, Brett Taylor, Fabio Vanoli, Hayley L Rein, Maria Jasin, Thomas Sandoval, Meghan R. Sullivan
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-24205-6⟩
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-24205-6⟩
Nature communications, 12(1):4255. Nature Publishing Group
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-24205-6⟩
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-24205-6⟩
Nature communications, 12(1):4255. Nature Publishing Group
Homology-directed repair (HDR), a critical DNA repair pathway in mammalian cells, is complex, leading to multiple outcomes with different impacts on genomic integrity. However, the factors that control these different outcomes are often not well unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f227ec43d84ca77e6f91bce3fcfae59
https://hal-amu.archives-ouvertes.fr/hal-03438617
https://hal-amu.archives-ouvertes.fr/hal-03438617
Autor:
Charles L. Sawyers, Teng Han, Danielle Choi, Brett S. Carver, Aura Agudelo Rivera, Rodrigo Romero, Huiyong Zhao, Qiao Wang, Maria Jasin, Elisa de Stanchina, Weiran Feng, Zhen Cao, Young Sun Lee, Pei Xin Lim, Hanzhi Luo, Chao Wu, Ninghui Mao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Modeling cancer formation requires introduction of relevant oncogenic perturbations into normal cells in a tissue/cell-type–specific manner. Genetically engineered mouse models are powerful but require significant time and cost to gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c59513cefba23d84bf7329e482787e9
https://doi.org/10.1073/pnas.2110344118
https://doi.org/10.1073/pnas.2110344118
Autor:
Weiran Feng, Zhen Cao, Pei Xin Lim, Huiyong Zhao, Hanzhi Luo, Ninghui Mao, Young Sun Lee, Rivera, Aura Agudelo, Choi, Danielle, Chao Wu, Teng Han, Romero, Rodrigo, de Stanchina, Elisa, Carver, Brett S., Qiao Wang, Jasin, Maria, Sawyers, Charles L.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 8/10/2021, Vol. 118 Issue 32, p1-7, 7p
Autor:
Prakash, Rohit, Sandoval, Thomas, Morati, Florian, Zagelbaum, Jennifer A., Pei-Xin Lim, White, Travis, Taylor, Brett, Wang, Raymond, Desclos, Emilie C. B., Sullivan, Meghan R., Rein, Hayley L., Bernstein, Kara A., Krawczyk, Przemek M., Gautier, Jean, Modesti, Mauro, Vanoli, Fabio, Jasin, Maria
Publikováno v:
Nature Communications; 7/12/2021, Vol. 8, p1-15, 15p
Autor:
Bor-Jang Hwang, Manpreet Basuita, Charlton Tsai, A-Lien Lu, Amy M. Lyndaker, Darshil R. Patel, Pei Xin Lim, Kelsey E. Poisson, Robert S. Weiss
Publikováno v:
Journal of Biological Chemistry. 290:14826-14840
The RAD9A-HUS1-RAD1 (9-1-1) complex is a heterotrimeric clamp that promotes checkpoint signaling and repair at DNA damage sites. In this study, we elucidated HUS1 functional residues that drive clamp assembly, DNA interactions, and downstream effecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f873dfac048d1d7160cf1641238b1b71
https://doi.org/10.1074/jbc.m114.630640
https://doi.org/10.1074/jbc.m114.630640
Autor:
Lyndaker, Amy M.1 (AUTHOR), Pei Xin Lim1 (AUTHOR), Mleczko1 (AUTHOR), Diggins, Catherine E.1 (AUTHOR), Holloway, J. Kim1 (AUTHOR), Holmes, Rebecca J.1 (AUTHOR), Rui Kan1 (AUTHOR), Schlafer, Donald H.1 (AUTHOR), Raimundo Freire2 (AUTHOR), Cohen, Paula E.1 (AUTHOR), Weiss, Robert S.1 (AUTHOR) rsw26@cornell.edu
Publikováno v:
PLoS Genetics. Jan2013, Vol. 9 Issue 1, p1-21. 21p. 6 Color Photographs, 2 Charts, 3 Graphs.
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The mammary gland undergoes significant proliferative stages after birth, but little is known about how the developmental changes impact DNA double-strand break (DSB) repair. Mutations in multiple genes involved in homology-directed repair (HDR), con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06b3eeeee1cdca0d8481f67bf08bbbc
http://europepmc.org/articles/PMC5093336
http://europepmc.org/articles/PMC5093336