Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Pei Xiang Xing"'
Publikováno v:
Cellular Immunology. 272:87-93
Pim-1 is an important signaling molecule mediating cell proliferation and survival. Our previous study identified a Pim-1 specific monoclonal antibody, P9, with significant inhibitory effect on cell proliferation. Herein, we report that P9 inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8068ec334a21ccdccdbd943f60d12a93
https://doi.org/10.1016/j.cellimm.2011.09.002
https://doi.org/10.1016/j.cellimm.2011.09.002
Publikováno v:
Experimental Hematology. 37:1284-1294
Objective Based on our previous findings that Pim-1 was expressed on the cell surface and could be targeted with a highly specific anti–Pim-1 monoclonal antibody (P9), this study aims to evaluate the possibility that Pim-1 could be targeted for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefe7a3be8d4476d06d426d27d45fd35
https://doi.org/10.1016/j.exphem.2009.08.002
https://doi.org/10.1016/j.exphem.2009.08.002
Autor:
D Kahn, Louise Baker, Andrew J. French, Lindsay Williams, Bruce R. Thorley, Peter Kyriakou, Dale Christiansen, Julie Milland, Bruce E. Loveland, Pei-Xiang Xing, Marc Lanteri, Ian F. C. McKenzie, Maureen Duffield, Mark van Regensburg, Malcolm R. Brandon
Publikováno v:
Xenotransplantation. 11:171-183
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9f26e692a933d3e791d7334cf2c8187
https://doi.org/10.1046/j.1399-3089.2003.00103_11_2.x
https://doi.org/10.1046/j.1399-3089.2003.00103_11_2.x
Autor:
Chunlei Liu, Ajit Bharti, Baizheng Song, Vasso Apostolopoulos, Stuart K. Calderwood, Yutaka Enomoto, Jianlin Gong, Pei-Xiang Xing, Ad Abdul Khaleque
Publikováno v:
Scopus-Elsevier
We have developed a molecular chaperone-based tumor vaccine that reverses the immune tolerance of cancer cells. Heat shock protein (HSP) 70 extracted from fusions of dendritic (DC) and tumor cells (HSP70.PC-F) possess superior properties such as stim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4061415c57e330de54dfcb18c415bbd1
https://doi.org/10.4049/jimmunol.177.9.5946
https://doi.org/10.4049/jimmunol.177.9.5946
Publikováno v:
Expert Review of Anticancer Therapy. 6:1261-1271
Ovarian cancer is often a lethal disease, since the occult progression of the tumor within the peritoneal cavity results in late diagnosis and treatment failure. The identification of molecular events specific to metastasis is critical for the develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a13fa3d43221afff318d61d348d8eac
https://doi.org/10.1586/14737140.6.8.1261
https://doi.org/10.1586/14737140.6.8.1261
Autor:
Pei Xiang Xing, Ingrid Hoffmann, Malte Bachmann, Christian Kosan, Mathias Montenarh, Tarik Möröy
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 38:430-443
The proto-oncogene Pim-1 encodes a serine-threonine kinase which is a downstream effector of cytokine signaling and can enhance cell cycle progression by altering the activity of several cell cycle regulators among them the G1 specific inhibitor p21(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6779694df17bb5a215a29770a2dadb6
https://doi.org/10.1016/j.biocel.2005.10.010
https://doi.org/10.1016/j.biocel.2005.10.010
Autor:
Hui K Gan, Anne Zhao, Paul Mitchell, Vaios Karanikas, Ian F. C. McKenzie, Peter Kyriakou, Kate Hamilton, Shane White, Vasso Apostolopoulos, Bruce E. Loveland, Pei-Xiang Xing, Hilary A. Vaughan, Geoffrey A. Pietersz
Publikováno v:
Clinical Cancer Research. 12:869-877
Purpose: Tumor antigen-loaded dendritic cells show promise for cancer immunotherapy. This phase I study evaluated immunization with autologous dendritic cells pulsed with mannan-MUC1 fusion protein (MFP) to treat patients with advanced malignancy. Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72214a310346efbc76ea3d6bf3e8c0f1
https://doi.org/10.1158/1078-0432.ccr-05-1574
https://doi.org/10.1158/1078-0432.ccr-05-1574
Autor:
Pei Xiang Xing, Xiu Feng Hu
Publikováno v:
Expert Opinion on Therapeutic Targets. 9:383-394
One of the recent, significant advances in cancer immunotherapy is the identification of molecules as targets which regulate cell growth by induction of proliferation and survival signalling pathways. Among them, epidermal growth factor receptor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae897c4236c6cb0b754a18dd24d6aea5
https://doi.org/10.1517/14728222.9.2.383
https://doi.org/10.1517/14728222.9.2.383
Publikováno v:
Molecular Cancer Research. 3:170-181
Elevated expression of the serine/threonine kinase Pim-1 increases the incidence of lymphomas in Pim-1 transgenic mice and has also been found to occur in some human cancers. Pim-1 acts as a cell survival factor and may prevent apoptosis in malignant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6bd31c1a07507dfab8a33d4a59aab8
https://doi.org/10.1158/1541-7786.mcr-04-0192
https://doi.org/10.1158/1541-7786.mcr-04-0192
Publikováno v:
Journal of Biological Chemistry. 279:48319-48328
The Pim-1 oncogene encodes a serine-threonine kinase that relays signals from cytokine receptors and contributes to the formation of lymphoid tumors when expressed at high levels. Here we show that the protein kinase Cdc25 C-associated kinase 1 (C-TA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e49706b6c9b311b867cd4185e73dffcd
https://doi.org/10.1074/jbc.m404440200
https://doi.org/10.1074/jbc.m404440200