Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Pei San, Yee"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Immunotherapy, especially the immune checkpoint inhibitors (ICIs) such as the pembrolizumab and nivolumab have contributed to significant improvements in treatment outcomes and survival of head and neck cancer (HNC) patients. Still, only a subset of
Externí odkaz:
https://doaj.org/article/9d2e7d54699141b896fc79923afb06eb
Autor:
Nur Syafinaz Zainal, Bernard Kok Bang Lee, Zheng Wei Wong, Iuan Sheau Chin, Pei San Yee, Chai Phei Gan, Kein Seong Mun, Zainal Ariff Abdul Rahman, J. Silvio Gutkind, Vyomesh Patel, Sok Ching Cheong
Publikováno v:
Cancer Biology & Medicine, Vol 16, Iss 2, Pp 264-275 (2019)
Objective Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma (OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including
Externí odkaz:
https://doaj.org/article/0cbed0837b6a4998adfdc5845bbf03bb
Autor:
Kai Hung Tiong, Jit Kang Chang, Dharini Pathmanathan, Muhammad Zaki Hidayatullah Fadlullah, Pei San Yee, Chee Sun Liew, Zainal Ariff Abdul Rahman, Kheng Ling Beh, Sok Ching Cheong
Publikováno v:
BioTechniques, Vol 65, Iss 6, Pp 322-330 (2018)
We describe a novel automated cell detection and counting software, QuickCount® (QC), designed for rapid quantification of cells. The Bland–Altman plot and intraclass correlation coefficient (ICC) analyses demonstrated strong agreement between cel
Externí odkaz:
https://doaj.org/article/40e512ec0d2d4d248c906a19fdb7b561
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway
Autor:
Annie Wai Yeeng Chai, Pei San Yee, Stacey Price, Shi Mun Yee, Hui Mei Lee, Vivian KH Tiong, Emanuel Gonçalves, Fiona M Behan, Jessica Bateson, James Gilbert, Aik Choon Tan, Ultan McDermott, Mathew J Garnett, Sok Ching Cheong
Publikováno v:
eLife, Vol 9 (2020)
New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived from Asians, to identify genetic vulnerabilities that can be explored as therap
Externí odkaz:
https://doaj.org/article/3808165fca334dd0b13ce47927c27467
Autor:
Pei San Yee, Annie Wai Yeeng Chai, Shi Mun Yee, Shi Yin Ooi, Yee Hua Tan, Mathew Garnett, Siew Kit Ng, Sok Ching Cheong
Publikováno v:
Cancer Research. 83:1704-1704
Treating oral squamous cell carcinoma (OSCC) remains challenging due to limited knowledge of the critical genes that could affect cell survival in OSCC. We have previously utilized genome-wide CRISPR-Cas9 knockout functional screens to explore the ge
Publikováno v:
Frontiers in oncology. 12
Immunotherapy, especially the immune checkpoint inhibitors (ICIs) such as the pembrolizumab and nivolumab have contributed to significant improvements in treatment outcomes and survival of head and neck cancer (HNC) patients. Still, only a subset of
Autor:
Pei San Yee, Chai Phei Gan, Vyomesh Patel, Kein Seong Mun, Nur Syafinaz Zainal, Mannil Thomas Abraham, Zainal Ariff Abdul Rahman, Siti Mazlipah Ismail, Sok Ching Cheong, Bernard Kok Bang Lee
Publikováno v:
Targeted Oncology. 14:223-235
Given that aberrant activation of epidermal growth factor receptor family receptors (ErbB) is a common event in oral squamous cell carcinoma, and that high expression of these receptor proteins is often associated with poor prognosis, this rationaliz
Autor:
Sharifah Nurain Syed Zanaruddin, Pei San Yee, Seen Yii Hor, Yink Heay Kong, Wan Maria Nabillah Wan Abd Ghani, Wan Mahadzir Wan Mustafa, Rosnah Binti Zain, Stephen S Prime, Zainal Ariff Abd Rahman, Sok-Ching Cheong
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80229 (2013)
ObjectivesThe frequency of common oncogenic mutations and TP53 was determined in Asian oral squamous cell carcinoma (OSCC).Materials and methodsThe OncoCarta(™) panel v1.0 assay was used to characterize oncogenic mutations. In addition, exons 4-11
Externí odkaz:
https://doaj.org/article/f2520dd8911c4275bef15354eea1df31
Autor:
James G. R. Gilbert, Emanuel Gonçalves, Aik Choon Tan, Stacey Price, Mathew J. Garnett, Pei San Yee, Vivian Kh Tiong, Hui Mei Lee, Ultan McDermott, Sok Ching Cheong, Jessica Bateson, Shi Mun Yee, Fiona M. Behan, Annie Wai Yeeng Chai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf00210826532268592d3bbc870ab5a5
https://doi.org/10.7554/elife.57761.sa2
https://doi.org/10.7554/elife.57761.sa2
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway
Autor:
Pei San Yee, Fiona M. Behan, Hui Mei Lee, Sok Ching Cheong, Emanuel Gonçalves, Annie Wai Yeeng Chai, Jessica Bateson, Stacey Price, Shi Mun Yee, James G. R. Gilbert, Ultan McDermott, Vivian Kh Tiong, Mathew J. Garnett, Aik Choon Tan
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived from Asians, to identify genetic vulnerabilities that can be explored as therap